EPN3 and TRIM26

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EPN3	TRIM26
Description		epsin 3	tripartite motif containing 26
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Plasma Membrane Clathrin-coated Pit Cytoplasmic Side Of Plasma Membrane Clathrin Vesicle Coat Clathrin-coated Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Clathrin Binding EH Domain Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Endocytosis	Immune System Process Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Host-mediated Suppression Of Symbiont Invasion Protein K11-linked Ubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Hip index ( 34021172)	Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) General cognitive ability ( 29844566) Hematocrit ( 32888494) LDL cholesterol levels ( 32203549) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Neuroticism ( 29255261) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 22883433 30285260 21926974) Squamous cell lung carcinoma ( 28604730) Triglyceride levels ( 32203549) Waist-hip index ( 34021172)
Interacting Genes		11 interacting genes: DAZAP2 FAM168A LAPTM5 LITAF NTAQ1 RNF11 RNF8 RPS27A TRIM26 UBA52 UBC	32 interacting genes: BEND7 BIVM CEBPD CTNNB1 DDX41 EPN2 EPN3 INCA1 IRF3 LMNA MACROH2A1 MAGEA6 MECOM MIR138-2 MIR18B MNAT1 OTUB2 PHF7 RABEP1 RNF126 SOX2 SUMO2 TAB1 THAP1 TLE5 TRIM41 UBC UBE2D1 UBE2D2 UBE2D3 USP5 ZEB1
Entrez ID		55040	7726
HPRD ID		06272	02901
Ensembl ID		ENSG00000049283	ENSG00000234127
Uniprot IDs		Q9H201	A0A024RCP3 Q12899
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Protein Tag Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Endocytic Vesicle Membrane Protein Modification Process Macromolecule Catabolic Process Endosome Membrane Regulation Of Non-canonical NF-kappaB Signal Transduction Proteolysis WW Domain Binding Vesicle Mitochondrial Outer Membrane Regulation Of Macrophage Cytokine Production Catabolic Process Induction Of Programmed Cell Death Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Lysosomal Membrane Permeability Protein-N-terminal Glutamine Amidohydrolase Activity Protein Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Protein Autoubiquitination Ubiquitin Protein Ligase Activity Regulation Of Lysosomal Membrane Permeability Cytoplasmic Side Of Late Endosome Membrane Positive Regulation Of Base-excision Repair Protein-N-terminal Asparagine Amidohydrolase Activity Lysosomal Membrane Cytosolic Ribosome Negative Regulation Of Autophagic Cell Death Ubiquitin Ligase Complex Cytoplasmic Side Of Early Endosome Membrane Regulation Of Base-excision Repair Cytoplasmic Translation Regulation Of Cytokine Production Involved In Immune Response Nucleus Positive Regulation Of DNA Repair Structural Constituent Of Ribosome Response To Insecticide Zinc Ion Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Receptor Catabolic Process	Negative Regulation Of Macromolecule Metabolic Process Nucleus Nucleoplasm Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Regulation Of Macromolecule Metabolic Process CGAS/STING Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin Conjugating Enzyme Activity Regulation Of Mesenchymal Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Protein Modification Process Negative Regulation Of Epithelial Cell Differentiation Clathrin Vesicle Coat Regulation Of RNA Metabolic Process Protein Monoubiquitination Protein Polyubiquitination Regulation Of Epithelial Cell Differentiation Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Tag Activity Ubiquitin Protein Ligase Activity Regulation Of Sister Chromatid Cohesion Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cell Cycle Positive Regulation Of Type I Interferon Production Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K48-linked Deubiquitination Proteolysis Negative Regulation Of Cell Communication
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