LUZP1 and TNFRSF4

Data Source: HiPPIP (Novel)

		LUZP1	TNFRSF4
Name		leucine zipper protein 1	TNF receptor superfamily member 4
Structure		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Stress Fiber Nucleus Chromosome Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Actin Filament Bicellular Tight Junction Actin Cytoskeleton Membrane Dendrite Midbody Ciliary Basal Body Cell Projection Perikaryon Spindle Midzone Extracellular Exosome Tight Junction Anchoring Junction CERF Complex	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding Microtubule Binding Actin Filament Binding	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding
	Biological Process	Ventricular Septum Development Apical Constriction Neural Fold Bending Contractile Ring Contraction Stress Fiber Assembly Artery Development Regulation Of Protein Complex Stability Negative Regulation Of Cilium Assembly Protein Localization To Actin Cytoskeleton	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Symbiont Entry Into Host Cell
Pathways		None	TNFs bind their physiological receptors
GWAS		Appendicular lean mass ( 33097823 ) Bell's palsy ( 33602968 ) Body mass index ( 29273807 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Global electrical heterogeneity phenotypes ( 29622589 ) Height ( 25282103 ) Hip circumference adjusted for BMI ( 34021172 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Inflammatory bowel disease ( 23128233 )
Novel Interactors		1 novel interactors: TNFRSF4	8 novel interactors: BTG2 DHX38 H6PD LUZP1 MAPK14 MLLT6 NAP1L5 PRRX1
Interacting Genes		1 interacting genes: HSPB1	10 interacting genes: NUFIP2 RC3H1 SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5
Entrez ID		7798	7293
HPRD ID		03250	02636
Ensembl ID		ENSG00000169641	ENSG00000186827
Uniprot IDs		Q05DE3 Q86V48	A0A8V8TQH5 P43489
PDB IDs		Not available	1D0A 2HEV 2HEY 6OGX 6OKM 6OKN 7YK4 8AG1
GO Terms Enriched among Interactors		Negative Regulation Of Protein Kinase C Signaling Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity Contractile Muscle Fiber Tumor Necrosis Factor Receptor Activity	Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Ubiquitin Protein Ligase Binding Regulation Of MRNA Metabolic Process Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of DNA-binding Transcription Factor Activity Regulation Of MRNA Stability MRNA Stabilization CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of RNA Stability Cell Surface Receptor Signaling Pathway Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of RNA Catabolic Process Protein Phosphatase Binding Negative Regulation Of MRNA Metabolic Process Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of T-helper Cell Differentiation Regulation Of Immune Response Post-transcriptional Regulation Of Gene Expression Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Cytokine Production Ubiquitin Protein Ligase Activity Negative Regulation Of Alpha-beta T Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Immune System Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Proliferation TORC2 Complex Disassembly Regulation Of T Cell Cytokine Production