ZNF121 and NCAN

Data Source: HiPPIP (Novel)

		ZNF121	NCAN
Name		zinc finger protein 121	neurocan
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Extracellular Space Golgi Lumen Lysosomal Lumen Synapse Perineuronal Net
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Skeletal System Development Cell Adhesion Central Nervous System Development
Pathways		None	Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS L1CAM interactions NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs		None	Beta-D-Glucose Thiodigalactoside Hyaluronic acid
GWAS		No GWAS studies recorded	Bipolar disorder ( 33263727 31043756 21353194 24618891 ) Bipolar I disorder ( 31043756 ) Bipolar II disorder ( 31043756 ) Brain morphology (MOSTest) ( 32665545 ) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809 ) Cholesterol, total ( 19060911 26780889 ) LDL cholesterol ( 26780889 18193043 19060911 19060906 ) Nonalcoholic fatty liver disease ( 29385134 ) Plateletcrit ( 32888494 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 23974872 29483656 ) Triglycerides ( 19060911 19060906 18193043 )
Novel Interactors		1 novel interactors: NCAN	5 novel interactors: CCDC9 GDF1 ZNF121 ZNF66 ZNF99
Interacting Genes		8 interacting genes: BARD1 CARD9 KEAP1 KRTAP10-8 RBAK TRIM41 ZNF835 ZNF837	8 interacting genes: CNTN2 HMGB1 L1CAM NCAM1 PTN PTPRF TNC TNR
Entrez ID		7675	1463
HPRD ID		15952	02897
Ensembl ID		ENSG00000197961	ENSG00000130287
Uniprot IDs		P58317	O14594
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Response To Muramyl Dipeptide	Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Neuron Projection Regeneration Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Tenascin Complex Regulation Of Response To Wounding Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Neuron Projection Guidance Axon Guidance Cell Adhesion Cell Migration Synapse Organization Cell Motility Cell Surface Regulation Of Plasma Membrane Bounded Cell Projection Organization Neuron Projection Regulation Of Cell Projection Organization Regeneration Regulation Of Axonogenesis Integrin Binding Extracellular Matrix Learning Cell Junction Organization Cell-cell Adhesion Regulation Of Synaptic Plasticity Telencephalon Cell Migration Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Cellular Response To Stress Forebrain Cell Migration Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Perisynaptic Extracellular Matrix Nervous System Development Chondroitin Sulfate Proteoglycan Binding Establishment Of Protein Localization To Juxtaparanode Region Of Axon Axon Development Regulation Of Cellular Component Organization Negative Regulation Of Cell Development Learning Or Memory Regulation Of Glial Cell Differentiation Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Cell Adhesion Negative Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Cell Clearance Extracellular Matrix Of Synaptic Cleft Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development