ZNF76 and EXOSC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF76	EXOSC1
Description		zinc finger protein 76	exosome component 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleic Acid Binding RNA Binding RNA Exonuclease Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase II	RRNA Processing RNA Processing RNA Catabolic Process
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Height ( 18391951 25282103 31562340) Plateletcrit ( 32888494) Refractive error ( 32231278)	Blood protein levels ( 30072576) Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Interacting Genes		93 interacting genes: ACAT2 ALOXE3 ANKRD37 ANTKMT ATP5PO BLZF1 BOLA2 BOLA2B C10orf55 C22orf15 C3orf36 CCDC33 CEACAM6 CEP76 CSN3 DDIT4L DISC1 ENKD1 EP300 EXOSC1 FAM228A FAM90A1 FCRL4 FNDC8 FSD2 GIMAP6 GRAPL HDAC1 HOMEZ HUNK IKZF3 KCTD9 KLF15 KPNA3 KRT40 KRT75 L3MBTL3 LAP3 LETM1 LHX3 LHX4 LHX6 LIN37 LIN54 LMO1 MAGEA6 MBD3L1 MBD5 MED19 MFAP1 MORN3 MRPL12 MTFR1L MTUS2 MYL10 NEDD9 NRIP2 PIAS1 PMPCA POGZ PRKAR1B RAB3IP RALY REL RNF214 RPRD1A RPS21 SCNM1 SLAIN1 SMAD1 SNAI2 SPANXN3 SPATA8 SPMIP10 STMN3 TASOR2 TBC1D22B TBP TEKT5 TGS1 TNNI1 USP54 USP6 USP7 VXN WDR83 YPEL3 ZC2HC1C ZC4H2 ZMYM6 ZNF420 ZNF526 ZNF623	36 interacting genes: A2M APP ASB9 CDC37 CPSF7 DDIT4L DMRTB1 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 FHL3 KCTD1 LNX1 LSM3 MAST1 NOS3 NUP160 PAK5 PRRC2B PTEN RBPMS REL RNF32 SF1 SH3GLB2 TCF4 TEX11 UPF2 WDR83 XRN1 ZNF143 ZNF76
Entrez ID		7629	51013
HPRD ID		01929	16223
Ensembl ID		ENSG00000065029	ENSG00000171311
Uniprot IDs		P36508	B1AMU3 Q9Y3B2
PDB IDs			2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Protein Binding Medial Motor Column Neuron Differentiation	Nuclear MRNA Surveillance Exoribonuclease Complex RRNA Catabolic Process U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Nuclear RNA Surveillance Nuclear Exosome (RNase Complex) Exosome (RNase Complex) RNA Surveillance SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing SnRNA Processing MRNA Catabolic Process RNA 3'-end Processing MRNA Metabolic Process SnRNA Metabolic Process RNA Catabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity RRNA 3'-end Processing TRNA Decay Nucleobase-containing Compound Catabolic Process RNA Processing RRNA Metabolic Process RNA Binding RRNA Processing Nucleus RNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Protein Binding Macromolecule Catabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation DNA Deamination Negative Regulation Of Gene Expression Histone MRNA Catabolic Process Synapse Maturation Nucleic Acid Metabolic Process Sno(s)RNA Metabolic Process Cytosol Regulation Of Gene Expression P-body Histone MRNA Metabolic Process
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