ZNF76 and ALOXE3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF76	ALOXE3
Description		zinc finger protein 76	arachidonate epidermal lipoxygenase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Lyase Activity Isomerase Activity Metal Ion Binding Intramolecular Hydroxytransferase Activity Dioxygenase Activity Hydroperoxy Icosatetraenoate Isomerase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase II	Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Sensory Perception Of Pain Arachidonate Metabolic Process Lipoxygenase Pathway Lipid Oxidation Peroxisome Proliferator Activated Receptor Signaling Pathway Linoleic Acid Metabolic Process Fat Cell Differentiation Ceramide Biosynthetic Process Hepoxilin Biosynthetic Process Establishment Of Skin Barrier
Pathways			Synthesis of 12-eicosatetraenoic acid derivatives
Drugs
Diseases			Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS		Height ( 18391951 25282103 31562340) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		93 interacting genes: ACAT2 ALOXE3 ANKRD37 ANTKMT ATP5PO BLZF1 BOLA2 BOLA2B C10orf55 C22orf15 C3orf36 CCDC33 CEACAM6 CEP76 CSN3 DDIT4L DISC1 ENKD1 EP300 EXOSC1 FAM228A FAM90A1 FCRL4 FNDC8 FSD2 GIMAP6 GRAPL HDAC1 HOMEZ HUNK IKZF3 KCTD9 KLF15 KPNA3 KRT40 KRT75 L3MBTL3 LAP3 LETM1 LHX3 LHX4 LHX6 LIN37 LIN54 LMO1 MAGEA6 MBD3L1 MBD5 MED19 MFAP1 MORN3 MRPL12 MTFR1L MTUS2 MYL10 NEDD9 NRIP2 PIAS1 PMPCA POGZ PRKAR1B RAB3IP RALY REL RNF214 RPRD1A RPS21 SCNM1 SLAIN1 SMAD1 SNAI2 SPANXN3 SPATA8 SPMIP10 STMN3 TASOR2 TBC1D22B TBP TEKT5 TGS1 TNNI1 USP54 USP6 USP7 VXN WDR83 YPEL3 ZC2HC1C ZC4H2 ZMYM6 ZNF420 ZNF526 ZNF623	2 interacting genes: YY1 ZNF76
Entrez ID		7629	59344
HPRD ID		01929	06231
Ensembl ID		ENSG00000065029	ENSG00000179148
Uniprot IDs		P36508	A0AAQ5BHH1 Q9BYJ1
PDB IDs			6VB2
Enriched GO Terms of Interacting Partners?		Protein Binding Medial Motor Column Neuron Differentiation	Sequence-specific DNA Binding Regulation Of DNA Strand Elongation V(D)J Recombination Immunoglobulin Heavy Chain V-D-J Recombination Negative Regulation Of Interferon-beta Production DNA-binding Transcription Repressor Activity Four-way Junction DNA Binding Sequence-specific Double-stranded DNA Binding Immunoglobulin V(D)J Recombination Ino80 Complex Response To Prostaglandin F Positive Regulation Of Telomere Maintenance In Response To DNA Damage Response To UV-C DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Chromatin Silencing Complex PcG Protein Complex Camera-type Eye Morphogenesis Negative Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Cardiac Muscle Tissue Growth Regulation Of Transcription By RNA Polymerase III Somatic Recombination Of Immunoglobulin Gene Segments RNA Localization Negative Regulation Of Organ Growth DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Striated Muscle Cell Differentiation Somatic Cell DNA Recombination Negative Regulation Of Muscle Hypertrophy Somatic Diversification Of Immunoglobulins Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Type I Interferon Production Negative Regulation Of Cardiac Muscle Hypertrophy SMAD Binding Cellular Response To Interleukin-1 Eye Morphogenesis Regulation Of Interferon-beta Production Regulation Of Heart Growth Positive Regulation Of Telomere Maintenance Sensory Organ Morphogenesis Negative Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Hypertrophy Response To Interleukin-1 Regulation Of MiRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Embryonic Development Cellular Response To UV
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