ZNF22 and BDKRB1

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		ZNF22	BDKRB1
Name		zinc finger protein 22	bradykinin receptor B1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Endoplasmic Reticulum Plasma Membrane Membrane
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Peptide Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Gene Expression Odontogenesis	Positive Regulation Of Leukocyte Migration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Mechanical Stimulus Cell Migration Negative Regulation Of Cell Growth Response To Lipopolysaccharide Negative Regulation Of Blood Pressure Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Pathways		None	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		None	Ramipril Captopril Zinc Enalaprilat Zinc acetate Zinc chloride Zinc sulfate, unspecified form
GWAS		No GWAS studies recorded	Metabolite levels ( 23823483 )
Novel Interactors		None recorded	2 novel interactors: DNAJB13 EVL
Interacting Genes		3 interacting genes: APP BDKRB1 CFTR	32 interacting genes: CERS1 DNAJB1 GABBR1 GNAQ GRIN1 HHATL HILPDA HTT INSIG1 LAPTM4B LRRC4C LTAP1 MBOAT7 MDC1 NAGPA NAP1L4 NDFIP1 NF2 OAZ2 RAE1 RETREG1 RTN4 SLC25A28 SLC39A14 SLC44A2 SLC6A8 TMEM42 TMX2 TRAM1L1 TRAT1 UQCRC1 ZNF22
Entrez ID		7570	623
HPRD ID		01917	02639
Ensembl ID		ENSG00000165512	ENSG00000100739
Uniprot IDs		P17026	P46663
PDB IDs		Not available	7EIB
GO Terms Enriched among Interactors		Regulation Of Monoatomic Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Cellular Response To CAMP Protein-folding Chaperone Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Transport Response To CAMP Positive Regulation Of Monoatomic Ion Transmembrane Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Purine-containing Compound Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Leukocyte Migration Developmental Maturation Early Endosome Membrane Recycling Endosome Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Calcium Ion Transport Lipoprotein Particle Response To Mechanical Stimulus Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Monoatomic Ion Transport Bradykinin Receptor Activity Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Endoplasmic Reticulum Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Protein Transport Positive Regulation Of Enamel Mineralization	Endoplasmic Reticulum Membrane Membrane Ferrous Iron Transmembrane Transporter Activity Brain Development Iron Ion Transmembrane Transporter Activity Negative Regulation Of Transport Profilin Binding