ZIC3 and TWIST1

Number of citations of the paper that reports this interaction (PubMedID 25402006)
0

Data Source:
BioGRID (pull down)

		ZIC3	TWIST1
Description		Zic family zinc finger 3	twist family bHLH transcription factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Protein Dimerization Activity E-box Binding DNA-binding Transcription Factor Binding
	Biological Process	Skeletal System Development Neural Plate Development Heart Looping Atrial Cardiac Muscle Tissue Development Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Determination Of Left/right Symmetry Gastrulation Pattern Specification Process Nervous System Development Central Nervous System Development Mesoderm Development Heart Development Embryonic Pattern Specification Anterior/posterior Pattern Specification Gene Expression Stem Cell Population Maintenance Hippocampus Development Olfactory Bulb Development Cell Differentiation Neuron Differentiation Lung Development Germ-line Stem Cell Population Maintenance Forebrain Development Limb Morphogenesis Central Nervous System Segmentation Determination Of Pancreatic Left/right Asymmetry Determination Of Left/right Asymmetry In Nervous System Outer Ear Morphogenesis MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Paraxial Mesoderm Development Stem Cell Differentiation Face Development Left/right Pattern Formation Left/right Axis Specification Determination Of Digestive Tract Left/right Asymmetry Determination Of Liver Left/right Asymmetry Primitive Streak Formation Maintenance Of Cell Number Cranial Skeletal System Development	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation In Utero Embryonic Development Neuron Migration Neural Tube Closure Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macrophage Cytokine Production Cell Differentiation Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Positive Regulation Of Fatty Acid Beta-oxidation Developmental Process Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Outer Ear Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of Skeletal Muscle Tissue Development Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Stem Cell Differentiation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cranial Suture Morphogenesis Embryonic Camera-type Eye Formation Eyelid Development In Camera-type Eye Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cellular Response To Hypoxia Positive Regulation Of Monocyte Chemotactic Protein-1 Production Energy Homeostasis Negative Regulation Of MiRNA Transcription Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Cell Motility Negative Regulation Of Cellular Senescence Negative Regulation Of Double-strand Break Repair Cell Proliferation Involved In Heart Valve Development Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation
Pathways		POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells	Interleukin-4 and Interleukin-13 signaling Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Nuclear events stimulated by ALK signaling in cancer Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases		Heterotaxy; Situs ambiguus	Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Refractive error ( 32231278)	Coronary artery disease ( 33020668 32469254) Diastolic blood pressure ( 30578418) Diisocyanate-induced asthma ( 25918132) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Large artery stroke (TOAST classification) ( 32047268) Male-pattern baldness ( 29146897) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pulse pressure ( 29403010 30487518 27841878 30578418) Systolic blood pressure ( 27841878 30487518 30578418) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		7 interacting genes: CTNNB1 GLI3 MESP1 SRF TP53 TWIST1 UBASH3A	30 interacting genes: BCL6 CHD4 EP300 FBXO45 GLI3 HOXA5 IKBKB KAT2B KMT5A KPNA5 KPNA7 MUC1 MYOD1 NEIL3 PTEN RBBP7 RELA SPOP STAT3 TCF3 TCF4 TP53 TRIB3 TRIM28 USP13 USP18 YY1 YY2 ZIC3 ZRANB1
Entrez ID		7547	7291
HPRD ID		02225	03374
Ensembl ID		ENSG00000156925	ENSG00000122691
Uniprot IDs		O60481	Q15672
PDB IDs		2EJ4 2RPC	2MJV 8OSB
Enriched GO Terms of Interacting Partners?		Heart Development Gastrulation Pattern Specification Process Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regionalization In Utero Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development Cis-regulatory Region Sequence-specific DNA Binding Stem Cell Differentiation Smooth Muscle Cell Differentiation Histone Deacetylase Binding Developmental Growth Animal Organ Development Tissue Morphogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Neuroblast Proliferation T Cell Differentiation In Thymus Cardiac Vascular Smooth Muscle Cell Differentiation Neuroblast Proliferation Embryonic Digit Morphogenesis Animal Organ Morphogenesis Formation Of Primary Germ Layer Cell Motility Forebrain Development Positive Regulation Of DNA-templated Transcription Initiation Cranial Suture Morphogenesis Regulation Of MiRNA Transcription Stem Cell Proliferation Embryonic Skeletal System Morphogenesis Embryonic Limb Morphogenesis Regulation Of Stem Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Initiation Vascular Associated Smooth Muscle Cell Differentiation Tube Morphogenesis Negative Regulation Of Cell Differentiation Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Neural Precursor Cell Proliferation Thymocyte Apoptotic Process Neural Precursor Cell Proliferation Tissue Development Hematopoietic Or Lymphoid Organ Development Morphogenesis Of An Epithelium	Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Chromatin Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation Cellular Response To Stress DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of Primary Metabolic Process Regulation Of Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Response To Stress Regulation Of Metabolic Process Chromatin Organization Chromatin Remodeling Regulation Of Cellular Response To Stress Cis-regulatory Region Sequence-specific DNA Binding Anterior/posterior Pattern Specification Chromatin DNA Binding DNA Damage Response
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