ZIC3 and GLI3

Number of citations of the paper that reports this interaction (PMID 11238441)
36

Data Source:
HPRD (in vitro)

		ZIC3	GLI3
Gene Name		Zic family member 3	GLI family zinc finger 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Mediator Complex Nuclear Speck Transcriptional Repressor Complex Primary Cilium Ciliary Tip Ciliary Base
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Beta-catenin Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Metal Ion Binding
	Biological Process	Heart Looping Transcription, DNA-templated Determination Of Left/right Symmetry Anterior/posterior Pattern Specification Lung Development Somatic Stem Cell Maintenance Determination Of Pancreatic Left/right Asymmetry Determination Of Left/right Asymmetry In Nervous System Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Determination Of Digestive Tract Left/right Asymmetry Determination Of Liver Left/right Asymmetry	Negative Regulation Of Transcription From RNA Polymerase II Promoter Metanephros Development Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Positive Regulation Of Neuroblast Proliferation Transcription, DNA-templated Smoothened Signaling Pathway Axon Guidance Hindgut Morphogenesis Heart Development Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Protein Processing Optic Nerve Morphogenesis Hippocampus Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Forebrain Dorsal/ventral Pattern Formation Cerebral Cortex Radial Glia Guided Migration Forebrain Radial Glial Cell Differentiation Lateral Ganglionic Eminence Cell Proliferation Melanocyte Differentiation Lung Development Positive Regulation Of Chondrocyte Differentiation T Cell Differentiation In Thymus Limb Morphogenesis Wound Healing Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Nose Morphogenesis Tongue Development Response To Estrogen Negative Thymic T Cell Selection Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Digestive Tract Development Developmental Growth Camera-type Eye Morphogenesis Embryonic Skeletal System Morphogenesis Oligodendrocyte Differentiation Palate Development Frontal Suture Morphogenesis Lambdoid Suture Morphogenesis Sagittal Suture Morphogenesis Mammary Gland Specification Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Artery Development Anterior Semicircular Canal Development Lateral Semicircular Canal Development Cell Differentiation Involved In Kidney Development Thymocyte Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Transcriptional regulation of pluripotent stem cells POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog GLI proteins bind promoters of Hh responsive genes to promote transcription GLI3 is processed to GLI3R by the proteasome
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23326517) Allergic rhinitis ( 22036096)
Protein-Protein Interactions		2 interactors: GLI3 SRF	17 interactors: BTRC CREBBP CSNK1A1 GSK3A MED12 PRKCA SKI SMAD1 SMAD2 SMAD3 SMAD4 STK36 SUFU TWIST1 ZIC1 ZIC2 ZIC3
Entrez ID		7547	2737
HPRD ID		02225	01313
Ensembl ID		ENSG00000156925	ENSG00000106571
Uniprot IDs		O60481	P10071
PDB IDs		2EJ4 2RPC
Enriched GO Terms of Interacting Partners?		Thymic T Cell Selection T Cell Selection Artery Development T Cell Differentiation In Thymus Hippocampus Development Limbic System Development Telencephalon Cell Migration Forebrain Cell Migration T Cell Differentiation Branching Morphogenesis Of An Epithelial Tube Pallium Development Sagittal Suture Morphogenesis Lambdoid Suture Morphogenesis Anterior Semicircular Canal Development Lateral Semicircular Canal Development Contractile Actin Filament Bundle Assembly Lateral Ganglionic Eminence Cell Proliferation Bone Development Lymphocyte Differentiation Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Anterior/posterior Pattern Specification Developmental Growth T Cell Aggregation T Cell Activation Lymphocyte Aggregation Telencephalon Development Leukocyte Aggregation Leukocyte Cell-cell Adhesion Embryonic Organ Morphogenesis Homotypic Cell-cell Adhesion Leukocyte Differentiation Negative Regulation Of Beta-amyloid Clearance Nose Morphogenesis Camera-type Eye Development Epithelial Tube Morphogenesis Eye Development Positive Regulation Of Neurogenesis Lymphocyte Activation Frontal Suture Morphogenesis Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Tube Morphogenesis Forebrain Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Mammary Gland Specification Pattern Specification Process Leukocyte Activation Embryonic Organ Development	Embryonic Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Tube Morphogenesis Tissue Morphogenesis Positive Regulation Of Transcription, DNA-templated Tube Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Embryo Development Epithelial Tube Morphogenesis Organ Development SMAD Protein Complex Assembly Pattern Specification Process Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Cell Differentiation Epithelium Development Positive Regulation Of Cellular Metabolic Process Heart Development Morphogenesis Of An Epithelium Regulation Of Cell Differentiation Regulation Of Signal Transduction Cardiovascular System Development Tissue Development Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Stem Cell Development Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter System Development Regulation Of Transcription, DNA-templated Stem Cell Maintenance Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Developmental Process Stem Cell Differentiation Regulation Of RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Transcription From RNA Polymerase II Promoter Response To Growth Factor Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Primary MiRNA Processing
Tagcloud ?		1g acvr2b argues asplenia cfc1 creld1 extracardiac foxh1 gata4 gdf1 gly17cys harbour heterotaxy heterozogous isomerism ivs2 lateralisation laterality leftya nkx2 oligogenic pedigrees pro21ser proband probands tga transposition unassociated val150ile	act antitumor application blocks cancers combined component could cyclopamine directions downstream enhance glioma gynecological hedgehog induce leading malignancy management mortality oncogene ovarian pathway proliferation reduce signaling silencing therefore
Tagcloud (Difference) ?		1g acvr2b argues asplenia cfc1 creld1 extracardiac foxh1 gata4 gdf1 gly17cys harbour heterotaxy heterozogous isomerism ivs2 lateralisation laterality leftya nkx2 oligogenic pedigrees pro21ser proband probands tga transposition unassociated val150ile	act antitumor application blocks cancers combined component could cyclopamine directions downstream enhance glioma gynecological hedgehog induce leading malignancy management mortality oncogene ovarian pathway proliferation reduce signaling silencing therefore
Tagcloud (Intersection) ?