ZIC3

Gene Name		Zic family member 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Heart Looping Transcription, DNA-templated Determination Of Left/right Symmetry Anterior/posterior Pattern Specification Lung Development Somatic Stem Cell Maintenance Determination Of Pancreatic Left/right Asymmetry Determination Of Left/right Asymmetry In Nervous System Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Determination Of Digestive Tract Left/right Asymmetry Determination Of Liver Left/right Asymmetry
Pathways		Transcriptional regulation of pluripotent stem cells POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: GLI3 SRF
Entrez ID		7547
HPRD ID		02225
Ensembl ID		ENSG00000156925
Uniprot IDs		O60481
PDB IDs		2EJ4 2RPC
Enriched GO Terms of Interacting Partners?		Thymic T Cell Selection T Cell Selection Artery Development T Cell Differentiation In Thymus Hippocampus Development Limbic System Development Telencephalon Cell Migration Forebrain Cell Migration T Cell Differentiation Branching Morphogenesis Of An Epithelial Tube Pallium Development Sagittal Suture Morphogenesis Lambdoid Suture Morphogenesis Anterior Semicircular Canal Development Lateral Semicircular Canal Development Contractile Actin Filament Bundle Assembly Lateral Ganglionic Eminence Cell Proliferation Bone Development Lymphocyte Differentiation Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Anterior/posterior Pattern Specification Developmental Growth T Cell Aggregation T Cell Activation Lymphocyte Aggregation Telencephalon Development Leukocyte Aggregation Leukocyte Cell-cell Adhesion Embryonic Organ Morphogenesis Homotypic Cell-cell Adhesion Leukocyte Differentiation Negative Regulation Of Beta-amyloid Clearance Nose Morphogenesis Camera-type Eye Development Epithelial Tube Morphogenesis Eye Development Positive Regulation Of Neurogenesis Lymphocyte Activation Frontal Suture Morphogenesis Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Tube Morphogenesis Forebrain Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Mammary Gland Specification Pattern Specification Process Leukocyte Activation Embryonic Organ Development
Tagcloud ?		1g acvr2b argues asplenia cfc1 creld1 extracardiac foxh1 gata4 gdf1 gly17cys harbour heterotaxy heterozogous isomerism ivs2 lateralisation laterality leftya nkx2 oligogenic pedigrees pro21ser proband probands tga transposition unassociated val150ile