RBM10 and MBD6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RBM10	MBD6
Description		RNA binding motif protein 10	methyl-CpG binding domain protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Speck Protein-containing Complex	Fibrillar Center Nucleus Nucleoplasm Chromosome Chromocenter
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding MiRNA Binding Identical Protein Binding Metal Ion Binding	DNA Binding Chromatin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome MRNA Processing Negative Regulation Of Cell Population Proliferation RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome 3'-UTR-mediated MRNA Stabilization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Apoptotic Process Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Ribosomal Large Subunit Export From Nucleus
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	UCH proteinases
Drugs
Diseases		TARP syndrome
GWAS			Brain morphology (MOSTest) ( 32665545)
Interacting Genes		73 interacting genes: AKAP9 ATN1 BAHD1 BEND7 CASK CBLL1 CCAR1 CEP70 CPSF7 CSNK2A1 DDX17 DDX5 FAM124A GTSE1 HNRNPH2 HNRNPK HNRNPLL IK KHDRBS2 KLF1 MAPRE2 MBD6 MDM2 MEOX2 MIR106B MIR107 MIR128-1 MIR21 MIR214 MIRLET7A1 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7G MIRLET7I NDEL1 NIN PATZ1 PCBP1 PRC1 PRCC PRDM14 PRR20A PTBP1 PTBP2 RBM12 RBM12B RBM14 RBM4 RBM7 RBMY1F RNF10 SF1 SF3A1 SF3B2 SF3B4 SLAIN1 SNRPA SNU13 SREK1 SRSF6 TBC1D22B THAP1 TLE5 U2AF1 UBQLN4 ZBTB24 ZFP64 ZNF275 ZNF317 ZNF408 ZNF473 ZNF526	4 interacting genes: ATXN1L DUSP12 NCK2 RBM10
Entrez ID		8241	114785
HPRD ID		02095	11296
Ensembl ID		ENSG00000182872	ENSG00000166987
Uniprot IDs		A0A0S2Z4W4 A0A0S2Z4X1 P98175	Q6P0P0 Q96DN6
PDB IDs		2LXI 2M2B 2MXV 2MXW 5ZSW 5ZSY
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process Regulation Of RNA Splicing Nucleic Acid Binding RNA Splicing Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RNA Processing Post-transcriptional Gene Silencing Spliceosomal Complex MRNA Splicing, Via Spliceosome MRNA Base-pairing Post-transcriptional Repressor Activity RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome RNA Binding MRNA Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleoplasm Nuclear Speck Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Regulation Of Primary Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Extracellular Vesicle Negative Regulation Of Translation Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Ribonucleoprotein Complex Pre-mRNA Binding MRNA 3'-UTR Binding Post-transcriptional Regulation Of Gene Expression U2-type Precatalytic Spliceosome Negative Regulation Of RNA Splicing Microtubule Nucleation	Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Ribosomal Large Subunit Export From Nucleus Smooth Muscle Cell Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Ribosome Biogenesis Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress POZ Domain Binding Regulation Of Ribosome Biogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Translation In Response To Stress Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Smooth Muscle Cell Proliferation Signal Complex Assembly Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Cell Population Proliferation Immunological Synapse Formation Dendritic Spine Development Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Protein Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of MRNA Splicing, Via Spliceosome 3'-UTR-mediated MRNA Stabilization Cytoskeletal Anchor Activity Regulation Of Translation In Response To Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Splicing Post-transcriptional Regulation Of Gene Expression MiRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Biosynthetic Process Signaling Receptor Complex Adaptor Activity Lamellipodium Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response
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