ZSWIM7 and UQCRB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZSWIM7	UQCRB
Description		zinc finger SWIM-type containing 7	ubiquinol-cytochrome c reductase binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Shu Complex	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III Respiratory Chain Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Protein Stabilization	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Cellular Respiration
Pathways			Respiratory electron transport Complex III assembly Complex III assembly
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin 5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Blood pressure (smoking interaction) ( 25189868)	Huntington's disease progression ( 28642124)
Interacting Genes		3 interacting genes: RAD51D UQCRB XRCC3	9 interacting genes: ACAP1 ACCS HPCA HSPB1 LRRK2 MAGEA1 MAGEA4 MAGEB4 ZSWIM7
Entrez ID		125150	7381
HPRD ID		19095	11770
Ensembl ID		ENSG00000214941	ENSG00000156467
Uniprot IDs		Q19AV6	P14927
PDB IDs			5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Recombination Mitotic Recombination Four-way Junction DNA Binding ATP-dependent DNA Damage Sensor Activity Replication Fork Interstrand Cross-link Repair Telomere Maintenance Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Chromosome, Telomeric Region Rad51C-XRCC3 Complex Telomere Maintenance Via Telomere Trimming Double-strand Break Repair DNA Recombination Rad51B-Rad51C-Rad51D-XRCC2 Complex Double-strand Break Repair Via Synthesis-dependent Strand Annealing DNA Strand Invasion Resolution Of Mitotic Recombination Intermediates Chromosome Organization Respiratory Chain Complex Resolution Of DNA Recombination Intermediates Crossover Junction DNA Endonuclease Activity Respiratory Chain Complex III Mitochondrial Electron Transport, Ubiquinol To Cytochrome C T-circle Formation Telomeric Loop Disassembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint DNA Repair Positive Regulation Of Cell Cycle Checkpoint Oxidative Phosphorylation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Reciprocal Meiotic Recombination DNA Metabolic Process ATP-dependent Activity, Acting On DNA Gamma-tubulin Binding DNA Damage Response Homologous Recombination Regulation Of Centrosome Duplication Regulation Of Centrosome Cycle Regulation Of Mitotic Sister Chromatid Separation Regulation Of Cell Cycle Aerobic Electron Transport Chain Regulation Of Chromosome Separation Microtubule Organizing Center Respiratory Electron Transport Chain Aerobic Respiration Regulation Of Mitotic Metaphase/anaphase Transition ATP Binding Electron Transport Chain	Response To Ketamine Dendrite Cytoplasm Negative Regulation Of Protein Kinase C Signaling Regulation Of Notch Signaling Pathway Negative Regulation Of Notch Signaling Pathway 1-aminocyclopropane-1-carboxylate Synthase Activity Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Shu Complex Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Kinase C Inhibitor Activity Positive Regulation Of Protein Autoubiquitination Response To Curcumin Perikaryon Response To Aroclor 1254 Dendritic Spine Head Regulation Of Protein Kinase C Signaling Histone Deacetylase Binding Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Dopamine Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Regulation Of Protein Autoubiquitination Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Targeting To Mitochondrion Regulation Of Kidney Size Tangential Migration From The Subventricular Zone To The Olfactory Bulb Calcium-mediated Signaling Cellular Response To Metal Ion Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Synaptic Vesicle Recycling Cellular Response To Dopamine Intracellular Distribution Of Mitochondria Regulation Of Retrograde Transport, Endosome To Golgi Cellular Response To L-glutamate Anterograde Axonal Protein Transport Regulation Of Intrinsic Apoptotic Signaling Pathway JUN Kinase Kinase Kinase Activity Positive Regulation Of Microglial Cell Activation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?