LAT2 and GAB1

Number of citations of the paper that reports this interaction (PMID 12486104)
48

Data Source:
HPRD (in vivo, in vitro)

		LAT2	GAB1
Gene Name		linker for activation of T cells family, member 2	GRB2-associated binding protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Mast Cell Granule Membrane Raft Extracellular Vesicular Exosome	Cytosol
	Molecular Function	Protein Binding SH2 Domain Binding	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway B Cell Activation Mast Cell Degranulation Innate Immune Response B Cell Receptor Signaling Pathway	Response To Oxidative Stress Epidermal Growth Factor Receptor Signaling Pathway Activation Of JUN Kinase Activity Heart Development Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Regulation Of Cell Migration Fc-epsilon Receptor Signaling Pathway Innate Immune Response Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Labyrinthine Layer Development Interleukin-6-mediated Signaling Pathway
Pathways		Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Innate Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling IRS-mediated signalling IGF1R signaling cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling IRS-related events triggered by IGF1R PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR PI3K Cascade Innate Immune System Signaling by Insulin receptor Signaling by PDGF Signalling by NGF DAP12 interactions Insulin receptor signalling cascade GAB1 signalosome IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR IRS-mediated signalling Downstream signal transduction Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Signaling by FGFR mutants PI3K/AKT Signaling in Cancer Constitutive Signaling by EGFRvIII PI3K Cascade Adaptive Immune System
Drugs
Diseases
GWAS			Asthma ( 21804548)
Protein-Protein Interactions		7 interactors: CBL GAB1 GRB2 PLCG1 PLCG2 SOS1 UBQLN4	31 interactors: ARHGAP32 C1QBP CRK CRKL EGFR EPOR FRS2 GAB2 GRAP2 GRB2 GTF2A1L INPP5D INSR LAT2 MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R PDGFRB PIK3CG PIK3R1 PLCG1 PLCG2 PTPN11 PTPN18 RET SHC1 SOS1
Entrez ID		7462	2549
HPRD ID		09304	05116
Ensembl ID		ENSG00000086730	ENSG00000109458
Uniprot IDs		Q9GZY6	Q13480 Q9HA84
PDB IDs		3MAZ
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Hemostasis Positive Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Response To Organic Substance Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Defense Response Regulation Of Body Fluid Levels Wound Healing Platelet Activation Cellular Response To Insulin Stimulus Response To Wounding Phospholipid Catabolic Process Leukocyte Migration Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phagocytosis Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Insulin Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Response To Peptide Inositol Phosphate Metabolic Process	Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Immune Response Positive Regulation Of MAPK Cascade Enzyme Linked Receptor Protein Signaling Pathway Immune Response Activation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Blood Coagulation Hemostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation ERBB Signaling Pathway Immune System Process Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Defense Response Wound Healing Signaling Cellular Response To Fibroblast Growth Factor Stimulus Cell Communication Response To Fibroblast Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of MAP Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity Response To Wounding Regulation Of Phosphorylation Regulation Of Immune System Process Positive Regulation Of Protein Modification Process
Tagcloud ?		adaptor allergic balance cascade collectively degranulation dysregulated effectors fcepsilonri gamma1 grb2 hyper ige ko lat1 linker linking mast negatively orchestrates plc proinflammatory reactions responsiveness signalosome slp tespa1 triggers tuning	adaptor amplifies antagonism bdl bile binder broad ccl5 chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride
Tagcloud (Difference) ?		allergic balance cascade collectively degranulation dysregulated effectors fcepsilonri gamma1 hyper ige ko lat1 linker linking mast negatively orchestrates plc proinflammatory reactions responsiveness signalosome slp tespa1 triggers tuning	amplifies antagonism bdl bile binder broad ccl5 chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1cko hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride
Tagcloud (Intersection) ?		adaptor grb2