VSNL1 and FAM131C

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (two hybrid)

		VSNL1	FAM131C
Description		visinin like 1	family with sequence similarity 131 member C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Signal Transduction Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion
Pathways
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Energy expenditure ( 30071075) Psychosis and Alzheimer's disease ( 22005930) Response to fenofibrate (total cholesterol levels) ( 27002377) Squamous cell lung carcinoma ( 28604730)	Cognitive performance ( 19734545) Normal facial asymmetry (angle of surface orientation score) ( 30631343)
Interacting Genes		18 interacting genes: ACTB ATXN1 C1QTNF2 CDSN CHRNA4 COL10A1 DTX2 ENDOD1 FAM131C GFI1B HUNK LITAF SPRED1 SPRED2 SPRY3 SRL TEX13B TFF1	12 interacting genes: APP CRYAA DNAJA3 EWSR1 GRN HPCAL4 LMO3 MAD1L1 NDN SFI1 VSNL1 WWP2
Entrez ID		7447	348487
HPRD ID		02890	08779
Ensembl ID		ENSG00000163032	ENSG00000185519
Uniprot IDs		P62760	Q96AQ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Lens Fiber Cell Differentiation Stem Cell Factor Receptor Binding Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Nuclear Matrix Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Negative Regulation Of Cornification Collagen Type X Trimer Negative Regulation Of MAPK Cascade Negative Regulation Of Neuron Projection Arborization Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Epithelial Cell Differentiation	Astrocyte Activation Involved In Immune Response Response To Heat Astrocyte Activation Central Nervous System Development Response To Temperature Stimulus Negative Regulation Of Signaling Microglial Cell Activation Negative Regulation Of Cell Communication Leukocyte Activation Involved In Inflammatory Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Neuron Recognition Synapse Organization Protein Stabilization Positive Regulation Of Aspartic-type Peptidase Activity MAD1 Complex Regulation Of Cell Activation Macrophage Activation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Protein Stability Negative Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Protein Folding Positive Regulation Of Trophectodermal Cell Proliferation Deactivation Of Mitotic Spindle Assembly Checkpoint Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex IkappaB Kinase Complex Binding Type II Interferon Receptor Binding Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein-folding Chaperone Binding Positive Regulation Of Mitotic Cell Cycle Response To Norepinephrine
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