VSNL1 and COL10A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VSNL1	COL10A1
Description		visinin like 1	collagen type X alpha 1 chain
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane	Extracellular Region Collagen Trimer Collagen Type X Trimer Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Metal Ion Binding
	Biological Process	Regulation Of Signal Transduction Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion	Skeletal System Development
Pathways			Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Non-integrin membrane-ECM interactions Collagen chain trimerization
Drugs
Diseases			Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Energy expenditure ( 30071075) Psychosis and Alzheimer's disease ( 22005930) Response to fenofibrate (total cholesterol levels) ( 27002377) Squamous cell lung carcinoma ( 28604730)	Age-related macular degeneration ( 21665990 23455636) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		18 interacting genes: ACTB ATXN1 C1QTNF2 CDSN CHRNA4 COL10A1 DTX2 ENDOD1 FAM131C GFI1B HUNK LITAF SPRED1 SPRED2 SPRY3 SRL TEX13B TFF1	10 interacting genes: ANXA5 BANP CIDEB MESD NRF1 P4HB SGTB UBQLN1 UBQLN2 VSNL1
Entrez ID		7447	1300
HPRD ID		02890	00357
Ensembl ID		ENSG00000163032	ENSG00000123500
Uniprot IDs		P62760	A0A650AXN9 Q03692
PDB IDs			1GR3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Lens Fiber Cell Differentiation Stem Cell Factor Receptor Binding Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Nuclear Matrix Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Negative Regulation Of Cornification Collagen Type X Trimer Negative Regulation Of MAPK Cascade Negative Regulation Of Neuron Projection Arborization Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Epithelial Cell Differentiation	Response To Endoplasmic Reticulum Stress Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Identical Protein Binding Positive Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Endothelial Microparticle Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Procollagen-proline 4-dioxygenase Complex Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of G Protein-coupled Receptor Internalization TRC Complex Negative Regulation Of Transport Autophagosome Organization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Peptidyl-proline Hydroxylation Negative Regulation Of Clathrin-dependent Endocytosis Procollagen-proline 4-dioxygenase Activity Cellular Response To Hypoxia Lipid Droplet Fusion Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Decreased Oxygen Levels
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