VSNL1 and ENDOD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VSNL1	ENDOD1
Description		visinin like 1	endonuclease domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane	Extracellular Region Cytosol Membrane Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Nucleic Acid Binding Nuclease Activity Endonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Regulation Of Signal Transduction Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion	Immune System Process Innate Immune Response
Pathways			Platelet degranulation
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Energy expenditure ( 30071075) Psychosis and Alzheimer's disease ( 22005930) Response to fenofibrate (total cholesterol levels) ( 27002377) Squamous cell lung carcinoma ( 28604730)	Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		18 interacting genes: ACTB ATXN1 C1QTNF2 CDSN CHRNA4 COL10A1 DTX2 ENDOD1 FAM131C GFI1B HUNK LITAF SPRED1 SPRED2 SPRY3 SRL TEX13B TFF1	1 interacting genes: VSNL1
Entrez ID		7447	23052
HPRD ID		02890	13819
Ensembl ID		ENSG00000163032	ENSG00000149218
Uniprot IDs		P62760	O94919
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Lens Fiber Cell Differentiation Stem Cell Factor Receptor Binding Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Nuclear Matrix Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Negative Regulation Of Cornification Collagen Type X Trimer Negative Regulation Of MAPK Cascade Negative Regulation Of Neuron Projection Arborization Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Epithelial Cell Differentiation	Mitochondrial Double-strand Break Repair Via Homologous Recombination Meiotic DNA Double-strand Break Formation Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Mre11 Complex BRCA1-C Complex Single-stranded DNA Endodeoxyribonuclease Activity 3'-5'-DNA Exonuclease Activity Regulation Of Mitotic Recombination Chromosomal Region Telomeric 3' Overhang Formation R-loop Processing DNA Strand Resection Involved In Replication Fork Processing 3'-5' Exonuclease Activity Mitotic Intra-S DNA Damage Checkpoint Signaling Replication Fork DNA Endonuclease Activity Telomere Maintenance Via Telomere Lengthening Homologous Chromosome Pairing At Meiosis RNA-templated DNA Biosynthetic Process DNA Strand Elongation Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Telomere Maintenance Via Telomerase DNA Double-strand Break Processing Reciprocal Meiotic Recombination Negative Regulation Of DNA Repair Mitotic G2 DNA Damage Checkpoint Signaling Sister Chromatid Cohesion Homologous Recombination DNA Helicase Activity Negative Regulation Of Double-strand Break Repair Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Exonuclease Activity Mitotic G2/M Transition Checkpoint Chromosome Organization Involved In Meiotic Cell Cycle Double-strand Break Repair Via Nonhomologous End Joining Manganese Ion Binding Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Telomere Maintenance Meiosis I Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Endonuclease Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of Protein Secretion Negative Regulation Of Hormone Secretion Positive Regulation Of Exocytosis Positive Regulation Of Insulin Secretion
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