UTRN and ACTN2

Number of citations of the paper that reports this interaction (PMID 12006649)
35

Data Source:
HPRD (in vitro)

		UTRN	ACTN2
Gene Name		utrophin	actinin, alpha 2
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Membrane Cell Junction Filopodium Filopodium Membrane Neuromuscular Junction Protein Complex Postsynaptic Membrane Extracellular Vesicular Exosome Contractile Ring	Extracellular Region Cytosol Cytoskeleton Actin Filament Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Integrin Binding Protein Binding Zinc Ion Binding Vinculin Binding Protein Kinase Binding	Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle LIM Domain Binding Thyroid Hormone Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Protein Dimerization Activity Actin Filament Binding FATZ Binding Titin Z Domain Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Muscle Contraction Muscle Organ Development Regulation Of Sodium Ion Transmembrane Transporter Activity	Platelet Degranulation Cell Adhesion Synaptic Transmission Blood Coagulation Microspike Assembly Muscle Filament Sliding Platelet Activation Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Focal Adhesion Assembly Protein Homotetramerization Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Receptor Activity
Pathways			Striated Muscle Contraction Platelet degranulation CREB phosphorylation through the activation of Ras Activation of NMDA receptor upon glutamate binding and postsynaptic events Response to elevated platelet cytosolic Ca2+ CREB phosphorylation through the activation of CaMKII Nephrin interactions Platelet activation, signaling and aggregation Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ACTA1 ACTN2 DAG1 DISC1 DMD DRP2 DTNA DTNB MARCH5 MARK2 PGM5 PTPN12 SNTA1 SNTB1 SNTB2 UBC	59 interactors: ACTN3 ADAM12 ADORA2A ANG ATXN2 ATXN7 BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 COIL DISC1 DLG1 DLG4 EPS8L1 ERBB2IP FAM154A FBXL22 GRIN1 GRIN2B ITGB3BP KAT2B KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MED14 MICALL2 MOS MYOZ1 MYOZ2 MYOZ3 MYPN NCOA2 NCOR1 NOS3 NR1I2 NRIP1 PALLD PDLIM1 PDLIM3 PKD2 RAVER1 RPL35 RTP5 SELE SNAI1 SNW1 SP100 SSX2IP ST7 SYNPO2 TNN TTN UTRN ZNF446
Entrez ID		7402	88
HPRD ID		00547	00019
Ensembl ID		ENSG00000152818	ENSG00000077522
Uniprot IDs		P46939 Q6LBS5	B2RCS5 P35609 Q59FD9
PDB IDs		1BHD 1QAG	1H8B 1HCI 1QUU
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Actin-myosin Filament Sliding Muscle Filament Sliding Negative Regulation Of Peptidyl-cysteine S-nitrosylation Actin-mediated Cell Contraction Actin Filament-based Movement Movement Of Cell Or Subcellular Component Myotube Cell Development Regulation Of Sodium Ion Transmembrane Transport Cellular Localization Cardiac Muscle Cell Action Potential Muscle Fiber Development Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Regulation Of Membrane Potential Myotube Differentiation Nerve Maturation Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Sodium Ion Transport Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Striated Muscle Contraction Regulation Of Striated Muscle Contraction Action Potential Skeletal Muscle Fiber Adaptation Establishment Of Glial Blood-brain Barrier Calcium-dependent Cell-matrix Adhesion Nerve Development Regulation Of Neuron Projection Development Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Glial Cell Development Positive Regulation Of Neurogenesis Peripheral Nervous System Development Regulation Of Ion Transmembrane Transport Regulation Of Cell Projection Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cell Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Establishment Of Blood-nerve Barrier Skeletal Muscle Tissue Development Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transmembrane Transporter Activity Skeletal Muscle Organ Development Microspike Assembly Regulation Of Neuron Differentiation Positive Regulation Of Cellular Protein Catabolic Process	Cytoskeleton Organization Regulation Of Ion Transport Organelle Organization Cell Communication Actin Filament-based Process Signaling Cellular Component Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Ion Transmembrane Transport Anatomical Structure Development Synaptic Transmission Positive Regulation Of Metabolic Process Cell Development Signal Transduction Movement Of Cell Or Subcellular Component Cell Differentiation Cell-cell Signaling Regulation Of Cellular Process Rhythmic Process Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Actin Cytoskeleton Organization Anatomical Structure Morphogenesis Protein Complex Assembly Regulation Of Potassium Ion Transport Striated Muscle Cell Differentiation Regulation Of Signaling Anatomical Structure Formation Involved In Morphogenesis Response To Organic Substance Regulation Of Sodium Ion Transport Response To Abiotic Stimulus Muscle System Process Negative Regulation Of Transport Striated Muscle Cell Development Positive Regulation Of Cellular Biosynthetic Process Myofibril Assembly Establishment Or Maintenance Of Apical/basal Cell Polarity Transcription Initiation From RNA Polymerase II Promoter Cell Adhesion Muscle Cell Development Cellular Calcium Ion Homeostasis Regulation Of Receptor Internalization Regulation Of Cellular Response To Heat Response To Stimulus Regulation Of Histone Deacetylase Activity Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Locomotion Negative Regulation Of Ion Transport
Tagcloud ?		11q13 12p12 12q13 14q21 17q11 18p11 20q11 6q 6q14 6q15 6q24 7q11 8p11 8q21 9p21 9q21 bcs cnas foxo3 kcnb2 mdn1 p12 p13 q13 q23 q24 q25 q34 tsgs	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Difference) ?		11q13 12p12 12q13 14q21 17q11 18p11 20q11 6q 6q14 6q15 6q24 7q11 8p11 8q21 9p21 9q21 bcs cnas foxo3 kcnb2 mdn1 p12 p13 q13 q23 q24 q25 q34 tsgs	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Intersection) ?