UTRN and NUP98

Data Source: HiPPIP (Novel)

		UTRN	NUP98
Name		utrophin	nucleoporin 98 and 96 precursor
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Dystrophin-associated Glycoprotein Complex Membrane Filopodium Filopodium Membrane Neuromuscular Junction Protein-containing Complex Ciliary Basal Body Sarcolemma Synapse Postsynaptic Membrane Extracellular Exosome Contractile Ring	Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Membrane Nuclear Body Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Cytoplasmic Filaments Nuclear Pore Nuclear Basket Ribonucleoprotein Complex
	Molecular Function	Actin Binding Integrin Binding Protein Binding Zinc Ion Binding Vinculin Binding Protein Kinase Binding Protein-containing Complex Binding Metal Ion Binding	Transcription Coactivator Activity RNA Binding MRNA Binding Protein Binding Nuclear Localization Sequence Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Structural Constituent Of Nuclear Pore Peptide Binding Molecular Condensate Scaffold Activity Promoter-specific Chromatin Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Muscle Contraction Muscle Organ Development Synaptic Signaling Regulation Of Sodium Ion Transmembrane Transport	Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus Proteolysis Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Protein Transport Telomere Tethering At Nuclear Periphery Positive Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Nuclear Pore Complex Assembly
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	None
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	None
GWAS		Age at first sexual intercourse ( 34211149 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Loneliness (multivariate analysis) ( 27629369 ) Multisite chronic pain ( 31194737 33830993 ) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954 ) Refractive error ( 32231278 ) Remission after SSRI treatment in MDD or openness ( 29559929 ) Response to fenofibrate (triglyceride levels) ( 27002377 ) Response to mepolizumab in severe asthma ( 29229094 ) Response to SSRI in MDD or openness ( 29559929 ) Restless legs syndrome in migraine without aura ( 32918390 )	Malaria ( 31844061 ) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736 )
Novel Interactors		2 novel interactors: NUP98 PRKACA	12 novel interactors: CBFA2T3 CHMP5 CYFIP1 HBE1 KCNQ1 MUC2 NUP214 PSMD13 RNH1 RRM1 SLC67A1-AS UTRN
Interacting Genes		20 interacting genes: ACTA1 ACTN2 C1QTNF9 CALM1 DAG1 DISC1 DMD DRP2 DTNA DTNB ITGB1BP1 MARCHF5 PCNT PGM5 PTEN PTPN12 SASH1 SNTA1 SNTB1 SNTB2	19 interacting genes: APC CREBBP CSNK2A1 EP300 HDAC1 IPO5 KPNB1 NUP133 NUP188 NUP205 NUP62 NUP88 NXF1 RAE1 RCC1 SEC13 TNPO1 TNPO2 TPR
Entrez ID		7402	4928
HPRD ID		00547	03012
Ensembl ID		ENSG00000152818	ENSG00000110713
Uniprot IDs		P46939 Q5T097 Q6LBS5	A0A8V8TR21 H0YCR0 H0YEN4 P52948
PDB IDs		1BHD 1QAG 6M5G	1KO6 2Q5X 2Q5Y 3MMY 4OWR 5A9Q 6BZM 7F60 7F90 7MNI 7PEQ 7Q64 7Q65 7Q66 7Q67 7VPG 7VPH 8CI8
GO Terms Enriched among Interactors		Dystrophin-associated Glycoprotein Complex Sarcolemma Cytoskeleton Synapse Focal Adhesion Costamere Filopodium Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Synaptic Signaling PDZ Domain Binding Muscle Contraction Actin Binding Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Syntrophin Complex Cell Projection Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cell Communication Muscle System Process Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cell-matrix Adhesion Structural Constituent Of Muscle Regulation Of Monoatomic Ion Transmembrane Transport Channel Activator Activity Protein-containing Complex Cell-substrate Junction Sarcomere Regulation Of System Process Regulation Of Metal Ion Transport Positive Regulation Of Cell-matrix Adhesion Dystroglycan Binding Structural Molecule Activity Cell-cell Signaling Cytoplasm Vinculin Binding Nitric-oxide Synthase Binding Calmodulin Binding Signaling Regulation Of Heart Contraction Titin Binding Anchoring Junction Regulation Of Monoatomic Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Cell-substrate Adhesion Cytoskeleton Organization Regulation Of Membrane Potential Nuclear Periphery Muscle Cell Development Plasma Membrane	Nuclear Pore Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Import Into Nucleus Nuclear Envelope RNA Transport Structural Constituent Of Nuclear Pore Protein Localization To Nucleus MRNA Transport Nucleobase-containing Compound Transport Establishment Of Protein Localization To Organelle RNA Export From Nucleus Protein Localization To Organelle Intracellular Transport Nuclear Export Intracellular Protein Transport Protein Transport Nuclear Localization Sequence Binding Cellular Localization Establishment Of Protein Localization Establishment Of Localization In Cell MRNA Export From Nucleus Intracellular Protein Localization Regulation Of Mitotic Spindle Organization Nuclear Import Signal Receptor Activity Regulation Of Microtubule Cytoskeleton Organization Nucleoplasm Cytosol Nuclear Pore Organization Histone H3K27 Acetyltransferase Activity Regulation Of Cytoskeleton Organization Nucleus Regulation Of Microtubule-based Process Nuclear Membrane Regulation Of Mitotic Spindle Assembly Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Nuclear Pore Inner Ring Small GTPase Binding Regulation Of Cell Cycle Kinetochore Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Nucleus Organization Regulation Of Spindle Assembly Positive Regulation Of Protein Localization To Nucleus Regulation Of Cell Cycle Process Positive Regulation Of Protein Import Into Nucleus