UTRN and SNTB1

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		UTRN	SNTB1
Name		utrophin	syntrophin beta 1
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Dystrophin-associated Glycoprotein Complex Membrane Filopodium Filopodium Membrane Neuromuscular Junction Protein-containing Complex Ciliary Basal Body Sarcolemma Synapse Postsynaptic Membrane Extracellular Exosome Contractile Ring	Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Dystrophin-associated Glycoprotein Complex Membrane Protein-containing Complex Sarcolemma Synapse Anchoring Junction
	Molecular Function	Actin Binding Integrin Binding Protein Binding Zinc Ion Binding Vinculin Binding Protein Kinase Binding Protein-containing Complex Binding Metal Ion Binding	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding PDZ Domain Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Muscle Contraction Muscle Organ Development Synaptic Signaling Regulation Of Sodium Ion Transmembrane Transport	Muscle Contraction
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	None
GWAS		Age at first sexual intercourse ( 34211149 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Loneliness (multivariate analysis) ( 27629369 ) Multisite chronic pain ( 31194737 33830993 ) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954 ) Refractive error ( 32231278 ) Remission after SSRI treatment in MDD or openness ( 29559929 ) Response to fenofibrate (triglyceride levels) ( 27002377 ) Response to mepolizumab in severe asthma ( 29229094 ) Response to SSRI in MDD or openness ( 29559929 ) Restless legs syndrome in migraine without aura ( 32918390 )	Apolipoprotein A1 levels ( 32203549 ) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809 ) Cerebrospinal T-tau levels ( 28247064 ) Eye morphology ( 29921221 ) HDL cholesterol levels ( 32203549 28334899 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) High density lipoprotein cholesterol levels ( 33339817 29083408 ) JT interval (sulfonylurea treatment interaction) ( 27958378 ) Myopia (pathological) ( 23406873 ) Myopia (severe) ( 23933737 ) Periodontitis (CDC/AAP) ( 24024966 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Thalamus volume ( 31530798 )
Interacting Genes		20 interacting genes: ACTA1 ACTN2 C1QTNF9 CALM1 DAG1 DISC1 DMD DRP2 DTNA DTNB ITGB1BP1 MARCHF5 PCNT PGM5 PTEN PTPN12 SASH1 SNTA1 SNTB1 SNTB2	15 interacting genes: ABCA1 ACVR2B ADGRB1 ADRA1D DGKZ DMD DTNA ERBB4 KCNJ12 MAPK12 RPS6KA1 SCN4A SCN5A UTRN VANGL2
Entrez ID		7402	6641
HPRD ID		00547	02490
Ensembl ID		ENSG00000152818	ENSG00000172164
Uniprot IDs		P46939 Q5T097 Q6LBS5	Q13884
PDB IDs		1BHD 1QAG 6M5G	7P70 7PC4
GO Terms Enriched among Interactors		Dystrophin-associated Glycoprotein Complex Sarcolemma Cytoskeleton Synapse Focal Adhesion Costamere Filopodium Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Synaptic Signaling PDZ Domain Binding Muscle Contraction Actin Binding Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Syntrophin Complex Cell Projection Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cell Communication Muscle System Process Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cell-matrix Adhesion Structural Constituent Of Muscle Regulation Of Monoatomic Ion Transmembrane Transport Channel Activator Activity Protein-containing Complex Cell-substrate Junction Sarcomere Regulation Of System Process Regulation Of Metal Ion Transport Positive Regulation Of Cell-matrix Adhesion Dystroglycan Binding Structural Molecule Activity Cell-cell Signaling Cytoplasm Vinculin Binding Nitric-oxide Synthase Binding Calmodulin Binding Signaling Regulation Of Heart Contraction Titin Binding Anchoring Junction Regulation Of Monoatomic Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Cell-substrate Adhesion Cytoskeleton Organization Regulation Of Membrane Potential Nuclear Periphery Muscle Cell Development Plasma Membrane	Muscle Contraction Muscle System Process Plasma Membrane Sarcolemma Muscle Organ Development Muscle Structure Development Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Cell Communication Regulation Of Multicellular Organismal Process Lateral Plasma Membrane Regulation Of Sodium Ion Transport Vinculin Binding Striated Muscle Contraction Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Complex Regulation Of Blood Circulation Regulation Of System Process Dystrophin-associated Glycoprotein Complex Regulation Of Striated Muscle Contraction Signal Transduction Cell-cell Signaling System Process Regulation Of Monoatomic Ion Transmembrane Transport Action Potential Regulation Of Skeletal Muscle Contraction Filopodium Membrane Voltage-gated Sodium Channel Activity Kinase Activity Signaling Establishment Of Planar Polarity Monoatomic Ion Channel Complex Synaptic Signaling Membrane Protein Serine/threonine/tyrosine Kinase Activity Phagocytosis, Engulfment Regulation Of Monoatomic Ion Transport Regulation Of Developmental Process Monoatomic Cation Channel Activity Regulation Of Muscle Contraction Sodium Channel Activity Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Developmental Process Regulation Of Biological Quality Regulation Of Heart Contraction Cardiac Muscle Contraction T-tubule ATP Binding Membrane Invagination Sphingolipid Floppase Activity