CLRN1 and ALG8

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CLRN1	ALG8
Name		clarin 1	ALG8 alpha-1,3-glucosyltransferase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Microvillus Microtubule Cytoskeleton Membrane Lamellipodium Trans-Golgi Network Transport Vesicle Stereocilium Basal Part Of Cell Actin-based Cell Projection	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity
	Biological Process	Actin Filament Organization Visual Perception Sensory Perception Of Sound Positive Regulation Of Lamellipodium Assembly Photoreceptor Cell Maintenance Cell Motility Neuromuscular Process Controlling Balance Sensory Perception Of Light Stimulus Equilibrioception Auditory Receptor Cell Stereocilium Organization Auditory Receptor Cell Development	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine
Pathways		None	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes CDG-1h
Diseases		Usher syndrome (US)	Congenital disorders of glycosylation (CDG) type I
GWAS		Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416 ) Chronotype ( 30696823 ) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600 )	Depression in smokers ( 30219690 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Tourette syndrome ( 30818990 )
Novel Interactors		1 novel interactors: MLF1	4 novel interactors: IQGAP2 NARS2 RSF1 TMEM126B
Interacting Genes		28 interacting genes: ALG8 BRICD5 C2CD2L CANT1 CCL4L2 CLDN19 CTXN3 DRAM1 FAM24B FUT9 ITGAM MGST3 NRM SEC22B SLC34A3 SLC61A1 TMEM140 TMEM147 TMEM222 TMEM239 TMEM31 TMEM50B TMEM86B TMIE TMPPE TMPRSS4 UNC50 ZDHHC15	12 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 LMNA MFSD6 NAE1 RPS6KA5 SAR1A
Entrez ID		7401	79053
HPRD ID		05905	10480
Ensembl ID		ENSG00000163646	ENSG00000159063
Uniprot IDs		P58418	A0A024R5K5 A0A7P0TA89 A0A7P0TAA8 A0A7P0Z449 A0A804G6E3 E9PR58 H0YCV0 H0YD42 H0YDD3 H0YEE0 Q9BVK2
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane	None