ALG8 and IQGAP2

		ALG8	IQGAP2
Description		ALG8 alpha-1,3-glucosyltransferase	IQ motif containing GTPase activating protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Lumenal Side Of Endoplasmic Reticulum Membrane	Cytoplasm Cytosol Microtubule Plasma Membrane Microvillus Cell Cortex Cell Surface Actin Cytoskeleton Lamellipodium Filopodium Secretory Granule Membrane Cell Leading Edge Extracellular Exosome Plasma Membrane Bounded Cell Projection
	Molecular Function	Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity	Actin Binding GTPase Inhibitor Activity GTPase Activator Activity Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Small GTPase Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine	Signal Transduction Regulation Of Actin Cytoskeleton Organization Arp2/3 Complex-mediated Actin Nucleation Thrombin-activated Receptor Signaling Pathway Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes CDG-1h	RHO GTPases activate IQGAPs Neutrophil degranulation CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Depression in smokers ( 30219690) Femur bone mineral density x serum urate levels interaction ( 34046847) Tourette syndrome ( 30818990)	A body shape index ( 34021172) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hearing impairment ( 20068591) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Late-onset Alzheimer's disease ( 27770636) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Phenylephrine infusion rate during anesthesia ( 31455332) Platelet count ( 32888494 27863252) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		12 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 LMNA MFSD6 NAE1 RPS6KA5 SAR1A	5 interacting genes: ACTR2 CALM1 CDC42 RAC1 RHOG
Entrez ID		79053	10788
HPRD ID		10480	09253
Ensembl ID		ENSG00000159063	ENSG00000145703
Uniprot IDs		A0A024R5K5 A0A7P0TA89 A0A7P0TAA8 A0A7P0Z449 A0A804G6E3 E9PR58 H0YCV0 H0YD42 H0YDD3 H0YEE0 Q9BVK2	B7Z7U6 B7Z7X2 F5H7S7 Q13576 Q59HA3
PDB IDs			3IEZ 4EZA 5CJP
Enriched GO Terms of Interacting Partners?			Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Lamellipodium Assembly Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Organization Actin Filament Organization Cellular Response To Type II Interferon G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Actin Cytoskeleton Organization Response To Type II Interferon Actin Filament-based Process Thioesterase Binding Focal Adhesion Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Protein Kinase Binding Supramolecular Fiber Organization Regulation Of Postsynapse Organization Cell Projection GTP-dependent Protein Binding Cytoskeleton Regulation Of Plasma Membrane Bounded Cell Projection Organization Rac Protein Signal Transduction Regulation Of Cell Projection Organization Regulation Of Ruffle Assembly Phagocytosis, Engulfment Postsynapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Postsynapse Assembly Substantia Nigra Development Cortical Cytoskeleton Organization Regulation Of Synapse Organization Membrane Invagination GTPase Activity Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Cytoskeleton Organization Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Endoplasmic Reticulum Membrane GTP Binding Cell Projection Assembly Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Projection Organization Positive Regulation Of Actin Filament Bundle Assembly Neural Nucleus Development Regulation Of Actin Filament-based Process
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