NMRAL1 and WDR48

Number of citations of the paper that reports this interaction (PubMedID 31796584)
32

Data Source:
BioGRID (pull down)

		NMRAL1	WDR48
Description		NmrA like redox sensor 1	WD repeat domain 48
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Lysosome Endosome Late Endosome Cytosol
	Molecular Function	Protein Binding Identical Protein Binding	DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Deubiquitinase Activator Activity Ubiquitin Binding
	Biological Process		Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Single Fertilization Male Gonad Development Multicellular Organism Growth Skin Development Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Embryonic Organ Development Skeletal System Morphogenesis Homeostasis Of Number Of Cells Positive Regulation Of Epithelial Cell Proliferation Regulation Of Macromolecule Metabolic Process Seminiferous Tubule Development Regulation Of Primary Metabolic Process Regulation Of Protein Monoubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Urea cycle	Recognition of DNA damage by PCNA-containing replication complex Ub-specific processing proteases Fanconi Anemia Pathway Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Drugs		2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID
Diseases
GWAS		Erectile dysfunction ( 30583798) Schizophrenia ( 28991256) Waist circumference adjusted for body mass index ( 28552196)	Metabolic syndrome ( 31589552) Social communication problems ( 24564958)
Interacting Genes		5 interacting genes: FOXJ1 MECOM PCNA USP1 WDR48	7 interacting genes: NMRAL1 PAXIP1 PCNA PHLPP1 RAD51 UBC USP1
Entrez ID		57407	57599
HPRD ID		13678	11146
Ensembl ID		ENSG00000153406	ENSG00000114742
Uniprot IDs		A0A384P622 Q9HBL8	A0A024R2L1 Q8TAF3
PDB IDs		2EXX 2WM3 2WMD 3DXF 3E5M	5CVL 5CVN 5CVO 5K1A 5K1B 5K1C 5L8E 5L8W 6JLQ 7AY0 7AY1 7AY2 8A9J 8A9K 9EBS 9HNW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Repair Positive Regulation Of DNA Metabolic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Macromolecule Metabolic Process Glomerular Parietal Epithelial Cell Development Positive Regulation Of Central B Cell Tolerance Induction Regulation Of DNA Metabolic Process PCNA Complex Regulation Of Cellular Response To Stress Replisome DNA Repair Regulation Of DNA Biosynthetic Process Positive Regulation Of Error-prone Translesion Synthesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Central Tolerance Induction Positive Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA Metabolic Process Response To UV Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding DNA Damage Response DNA Binding Metanephric Part Of Ureteric Bud Development Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Ciliary Basal Body Organization Tube Development Histone H3K9 Monomethyltransferase Activity Regulation Of Protein Monoubiquitination Regulation Of Primary Metabolic Process MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Deubiquitinase Activator Activity Positive Regulation Of Macromolecule Biosynthetic Process Histone H3K9me2 Methyltransferase Activity Developmental Process Regulation Of Germinal Center Formation	Regulation Of DNA Metabolic Process Response To Radiation DNA Repair DNA Polymerase Binding Replication Fork Processing DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA Repair Male Germ Cell Nucleus DNA Damage Response PCNA Complex Replisome Response To Glucoside Positive Regulation Of Error-prone Translesion Synthesis PCNA-p21 Complex Telomere Maintenance DNA Polymerase Processivity Factor Activity Regulation Of DNA Biosynthetic Process Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleic Acid Metabolic Process Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton Spermatocyte Division Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Chorion Development Regulation Of Cellular Response To Stress Telomere Organization Positive Regulation Of DNA Repair Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Regulation Of DNA Recombination Cellular Response To Cisplatin Response To Ionizing Radiation LncRNA Transcription Response To UV DNA Strand Invasion DNA Recombinase Assembly Cellular Response To Camptothecin Nucleobase-containing Compound Metabolic Process Nucleoplasm Cellular Response To Radiation Nuclear Ubiquitin Ligase Complex Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Response To Cisplatin Chromosome, Telomeric Region MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication
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