ADRA2C and EIF2B1

Number of citations of the paper that reports this interaction (PubMedID 9235896)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		ADRA2C	EIF2B1
Description		adrenoceptor alpha 2C	eukaryotic translation initiation factor 2B subunit alpha
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GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Membrane	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Alpha-2A Adrenergic Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Smooth Muscle Contraction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Platelet Activation Negative Regulation Of Epinephrine Secretion Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Adrenergic Receptor Signaling Pathway	Cytoplasmic Translational Initiation Translation Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone T Cell Receptor Signaling Pathway
Pathways		Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism	Recycling of eIF2:GDP
Drugs		Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Clozapine Norepinephrine Phenylpropanolamine Loxapine Prochlorperazine Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Clonidine Lisuride Ergotamine Tizanidine Apomorphine Paroxetine Risperidone Tolazoline Fenoldopam Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Promethazine Carvedilol Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine Dextroamphetamine Metamfetamine Celiprolol Dronedarone Iloperidone OPC-28326 Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Esmirtazapine Xylometazoline Levonordefrin Tetryzoline Lurasidone Agmatine Brexpiprazole Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine Xylazine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases			Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Blood urea nitrogen levels ( 31152163) Lung cancer in ever smokers ( 28604730) Nickel levels ( 26025379) Urinary potassium excretion ( 31409800)	Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		17 interacting genes: CCDC24 CHCHD2 CNPY2 EIF2B1 GNAO1 HGS KLHL38 KRT34 MDFI MEIS2 MGAT5B MKRN3 P4HA3 PPP1R9B UCHL1 WWOX YWHAZ	21 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D ATF5 BZW2 C1orf50 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MED29 MRPL4 NTAQ1 RD3 TRIM59 TRIML2 UBE2I
Entrez ID		152	1967
HPRD ID		00085	09458
Ensembl ID		ENSG00000184160	ENSG00000111361
Uniprot IDs		P18825 Q4W594	Q14232
PDB IDs		6KUW	3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMA 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQZ
Enriched GO Terms of Interacting Partners?			Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Adrenergic Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Regulation Of Norepinephrine Secretion Negative Regulation Of Catecholamine Secretion Regulation Of Smooth Muscle Contraction Norepinephrine Binding Eukaryotic Translation Initiation Factor 2 Complex Regulation Of Catecholamine Secretion Translation Initiation Factor Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Uterine Smooth Muscle Contraction Regulation Of Muscle Contraction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Vasoconstriction Platelet Activation Negative Regulation Of Smooth Muscle Contraction ERBB Signaling Pathway Regulation Of Amine Transport Translational Initiation Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Muscle System Process Negative Regulation Of Muscle Contraction Vascular Process In Circulatory System Regulation Of Translational Initiation Circulatory System Process Cytoplasmic Translational Initiation Negative Regulation Of Insulin Secretion Negative Regulation Of Secretion By Cell G Protein-coupled Receptor Activity Negative Regulation Of Uterine Smooth Muscle Contraction Alpha-1B Adrenergic Receptor Binding Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Temperature Stimulus Translation Initiation Ternary Complex Translation SUMO Conjugating Enzyme Activity Carbohydrate Phosphatase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Guanylate Cyclase Activity Negative Regulation Of Secretion Negative Regulation Of Peptide Secretion Macromolecule Biosynthetic Process Protein Metabolic Process
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