ADRA2C and CNPY2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ADRA2C	CNPY2
Name		adrenoceptor alpha 2C	canopy FGF signaling regulator 2
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Membrane	Endoplasmic Reticulum
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Alpha-2A Adrenergic Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding	Protein Binding
	Biological Process	Regulation Of Smooth Muscle Contraction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Platelet Activation Negative Regulation Of Epinephrine Secretion Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Adrenergic Receptor Signaling Pathway	Negative Regulation Of Gene Expression Regulation Of Low-density Lipoprotein Particle Clearance
Pathways		Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism	None
Drugs		Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Clozapine Norepinephrine Phenylpropanolamine Loxapine Prochlorperazine Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Clonidine Lisuride Ergotamine Tizanidine Apomorphine Paroxetine Risperidone Tolazoline Fenoldopam Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Promethazine Carvedilol Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine Dextroamphetamine Metamfetamine Celiprolol Dronedarone Iloperidone OPC-28326 Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Esmirtazapine Xylometazoline Levonordefrin Tetryzoline Lurasidone Agmatine Brexpiprazole Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine Xylazine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil	None
GWAS		Blood urea nitrogen levels ( 31152163 ) Lung cancer in ever smokers ( 28604730 ) Nickel levels ( 26025379 ) Urinary potassium excretion ( 31409800 )	Height ( 31562340 34270706 ) Refractive error ( 32231278 ) Waist circumference adjusted for body mass index ( 26785701 )
Novel Interactors		1 novel interactors: WFS1	1 novel interactors: RAB27B
Interacting Genes		17 interacting genes: CCDC24 CHCHD2 CNPY2 EIF2B1 GNAO1 HGS KLHL38 KRT34 MDFI MEIS2 MGAT5B MKRN3 P4HA3 PPP1R9B UCHL1 WWOX YWHAZ	4 interacting genes: ADRA2C APP MLXIP MYLIP
Entrez ID		152	10330
HPRD ID		00085	12056
Ensembl ID		ENSG00000184160	ENSG00000257727
Uniprot IDs		P18825 Q4W594	Q9Y2B0
PDB IDs		6KUW	Not available
GO Terms Enriched among Interactors		None	Positive Regulation Of Neuron Differentiation Alpha-2A Adrenergic Receptor Binding Endosome Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Epinephrine Secretion Regulation Of Neuron Differentiation Negative Regulation Of Protein Localization Alpha2-adrenergic Receptor Activity Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Axo-dendritic Transport Intermediate-density Lipoprotein Particle Cytoskeleton-dependent Intracellular Transport Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Microtubule-based Transport Transport Along Microtubule Amylin Binding Positive Regulation Of Protein Catabolic Process Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Platelet Dense Granule Membrane Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Axon Choice Point Recognition Regulation Of Blood Circulation