C11orf65 and CALML3

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		C11orf65	CALML3
Name		chromosome 11 open reading frame 65	calmodulin like 3
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane	Cytoplasm Centrosome Synaptic Vesicle Membrane Myelin Sheath Extracellular Exosome
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Mitochondrial Fission Negative Regulation Of Protein Targeting To Mitochondrion	Detection Of Calcium Ion Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcineurin-mediated Signaling
GWAS		Granulocyte count ( 27863252 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 29403010 ) Mean corpuscular volume ( 32888494 29403010 ) Mean platelet volume ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 32888494 ) Nonunion in individuals with fractures ( 30680360 ) Platelet count ( 27863252 ) Platelet distribution width ( 32888494 ) Red blood cell count ( 32888494 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Uterine fibroids ( 31649266 30194396 ) White blood cell count ( 27863252 32888494 )	Fasting insulin ( 34074324 )
Novel Interactors		1 novel interactors: POGLUT3	1 novel interactors: IL2RA
Interacting Genes		7 interacting genes: ATOSB CALM1 CALM2 CALM3 CALML3 DAPK1 SUMO1	9 interacting genes: BHLHE40 C11orf65 IQCB1 IQCN ISOC2 MAPK4 MFHAS1 MYO10 TERF2IP
Entrez ID		160140	810
HPRD ID		14579	00244
Ensembl ID		ENSG00000166323	ENSG00000178363
Uniprot IDs		Q8NCR3	P27482
PDB IDs		Not available	1GGZ
GO Terms Enriched among Interactors		Detection Of Calcium Ion Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Negative Regulation Of Transporter Activity Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Cation Transmembrane Transport Titin Binding Regulation Of Calcium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Complex Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Monoatomic Cation Transmembrane Transport Protein Phosphatase Activator Activity Calyx Of Held Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Striated Muscle Contraction Negative Regulation Of Monoatomic Ion Transport Catalytic Complex Detection Of Chemical Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Metal Ion Negative Regulation Of Transmembrane Transport Calcium Channel Complex Regulation Of Metal Ion Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Sequestering Of Calcium Ion Synaptic Vesicle Membrane Response To Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Monoatomic Ion Transport Negative Regulation Of Calcium Ion Transmembrane Transport Calcium-mediated Signaling Regulation Of Muscle Contraction Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Regulation Of Heart Contraction	None