CPOX and UBE2G2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CPOX	UBE2G2
Gene Name		coproporphyrinogen oxidase	ubiquitin-conjugating enzyme E2G 2
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Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space	Endoplasmic Reticulum Cytosol
	Molecular Function	Coproporphyrinogen Oxidase Activity Structural Constituent Of Eye Lens Protein Homodimerization Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Response To Iron Ion Response To Lead Ion Response To Insecticide Small Molecule Metabolic Process Response To Arsenic-containing Substance Response To Methylmercury Oxidation-reduction Process	Ubiquitin-dependent Protein Catabolic Process Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways		Heme biosynthesis Metabolism of porphyrins	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: UBE2G2	37 interactors: AMFR ARL14 BIRC8 CBL CNNM3 CPOX CUL9 FARP2 HBS1L HERPUD1 KDM2A KIAA0368 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 PARK2 POLR3F RBX1 RFFL RNF111 RNF146 RNF157 RNF168 RNF26 RNF5 TMEM45B TRIM3 TRIM43 UBA1 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4
Entrez ID		1371	7327
HPRD ID		00417	04387
Ensembl ID		ENSG00000080819	ENSG00000184787
Uniprot IDs		P36551	P60604
PDB IDs		2AEX	2CYX 2KLY 2LXP 3H8K 4LAD
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination ER-associated Ubiquitin-dependent Protein Catabolic Process Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation	Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Polyubiquitination Catabolic Process Proteolysis Cellular Protein Metabolic Process Cellular Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Protein Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To Stress Cellular Metabolic Process Regulation Of Proteolysis Regulation Of Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Ubiquitination Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Signal Transduction Protein K63-linked Ubiquitination Cellular Response To Topologically Incorrect Protein Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Regulation Of Mitochondrial Fusion Protein Autoubiquitination Response To Stimulus Response To Unfolded Protein Regulation Of Protein Stability Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Stimulus Response To Organic Substance Positive Regulation Of Mitochondrial Fission Regulation Of Intracellular Signal Transduction Response To Stress Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		1252t 280insat 287c 364g 442delca 445c 76c 887delc 917t ahp aip bulgarian c418r coproporphyria coproporphyrinogen e122x hmbs hydroxymethylbilane l306p nonsense porphyria ppox probands protoporphyrinogen r149x r26c s96f variegate vp	alters assembly attack bond catalyzes chain chains cooperative cooperatively correct cue distal donor drive e3 elusive g2br gp78 helps lys48 monoubiquitin orientation polyubiquitin preassembled preferential thioester transferring ubiquitin
Tagcloud (Difference) ?		1252t 280insat 287c 364g 442delca 445c 76c 887delc 917t ahp aip bulgarian c418r coproporphyria coproporphyrinogen e122x hmbs hydroxymethylbilane l306p nonsense porphyria ppox probands protoporphyrinogen r149x r26c s96f variegate vp	alters assembly attack bond catalyzes chain chains cooperative cooperatively correct cue distal donor drive e3 elusive g2br gp78 helps lys48 monoubiquitin orientation polyubiquitin preassembled preferential thioester transferring ubiquitin
Tagcloud (Intersection) ?