UBC and UBE2D3

Number of citations: 74 (PubMedID 34642328)
Data Source: BioGRID (x-ray crystallography, pull down)

		UBC	UBE2D3
Name		ubiquitin C	ubiquitin conjugating enzyme E2 D3
Structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Membrane Endocytic Vesicle Membrane Vesicle Extracellular Exosome	Nucleus Nucleoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination Modification-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process DNA Damage Response Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Activation of NF-kappaB in B cells ISG15 antiviral mechanism Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants ER-Phagosome pathway Downregulation of ERBB4 signaling Spry regulation of FGF signaling Downregulation of ERBB2:ERBB3 signaling Budding and maturation of HIV virion NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment DDX58/IFIH1-mediated induction of interferon-alpha/beta APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Membrane binding and targetting of GAG proteins Assembly Of The HIV Virion APC-Cdc20 mediated degradation of Nek2A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G EGFR downregulation SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex TCF dependent signaling in response to WNT Downstream TCR signaling NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival Regulation of activated PAK-2p34 by proteasome mediated degradation NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Separation of Sister Chromatids Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Stimuli-sensing channels Constitutive Signaling by NOTCH1 HD Domain Mutants FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of innate immune responses to cytosolic DNA Glycogen synthesis Autodegradation of the E3 ubiquitin ligase COP1 Deactivation of the beta-catenin transactivating complex Myoclonic epilepsy of Lafora ABC-family proteins mediated transport TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Regulation of FZD by ubiquitination PINK1-PRKN Mediated Mitophagy N-glycan trimming in the ER and Calnexin/Calreticulin cycle Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Hedgehog 'on' state Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway Negative regulation of MAPK pathway Regulation of necroptotic cell death NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAP3K8 (TPL2)-dependent MAPK1/3 activation HDR through Homologous Recombination (HRR) MAPK6/MAPK4 signaling UCH proteinases UCH proteinases Josephin domain DUBs Ub-specific processing proteases Ovarian tumor domain proteases Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Negative regulation of MET activity Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Cyclin D associated events in G1 G2/M Checkpoints Stabilization of p53 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling VLDLR internalisation and degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell InlA-mediated entry of Listeria monocytogenes into host cells RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN localization Regulation of PTEN stability and activity Neddylation ER Quality Control Compartment (ERQC) Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling Peroxisomal protein import Peroxisomal protein import Interferon alpha/beta signaling Regulation of signaling by CBL Endosomal Sorting Complex Required For Transport (ESCRT) Iron uptake and transport Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Negative regulation of NOTCH4 signaling Chaperone Mediated Autophagy Late endosomal microautophagy Prevention of phagosomal-lysosomal fusion Modulation by Mtb of host immune system Alpha-protein kinase 1 signaling pathway Aggrephagy Aggrephagy RAS processing Pexophagy Signaling by CSF1 (M-CSF) in myeloid cells Maturation of protein E SARS-CoV-1 activates/modulates innate immune responses Maturation of protein E Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Negative regulation of FLT3 FLT3 signaling by CBL mutants Regulation of BACH1 activity Signaling by ALK fusions and activated point mutants TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation KEAP1-NFE2L2 pathway Regulation of NF-kappa B signaling GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Amyloid fiber formation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses Regulation of pyruvate metabolism GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) PD-L1(CD274) glycosylation and translocation to plasma membrane Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		N-Formylmethionine	None
GWAS		HDL cholesterol levels ( 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) High density lipoprotein cholesterol levels ( 29403010 33339817 ) Total cholesterol levels ( 29403010 )	Alanine aminotransferase levels ( 33547301 ) Asthma and attention deficit hyperactivity disorder ( 31619474 ) Diastolic blood pressure ( 30224653 ) Shoulder impingement or rotator cuff tear ( 33482370 )
Interacting Genes		1079 interacting genes: ABCB7 ABCD3 ABL1 ABRAXAS1 ABRAXAS2 ACAD11 ACOT9 ACTA1 ACTB ACTC1 ACTL6A ACTL8 ADH7 AGO2 AGRN AGTPBP1 AHCY ALDH1L2 ALG1 AMBRA1 AMER1 AMFR AMOT AMPH ANAPC1 ANAPC11 ANAPC2 ANAPC7 ANGPTL3 ANKFY1 ANKHD1 ANKIB1 ANKRD13A ANKRD13B ANKRD13D ANKRD30A ANKS1A ANKS1B ANKZF1 ANP32E AP1M1 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APEX2 APLP2 APOBEC3C APPL1 AREL1 ARIH1 ARIH2 ARK2C ARK2N ARMC1 ARRB2 ASB11 ASB2 ASB3 ASCC1 ASCC2 ASCC3 ASPHD1 ASPSCR1 ASXL1 ASXL2 ATF7 ATP5PD ATP6V1A ATXN3 ATXN3L ATXN7L3 AUP1 AVEN AXL B3GALT1 B4GALT7 BABAM1 BABAM2 BAG1 BAG3 BAIAP2 BAP1 BARD1 BARX1 BBS2 BCAS2 BCKDK BCL2L13 BCR BECN1 BFAR BIN1 BIRC2 BIRC3 BIRC6 BIVM-ERCC5 BMERB1 BRAP BRCA1 BRCC3 BRF1 BSG BTBD1 BTBD9 BTD BTRC BUB1 BUD23 C1orf50 C8orf34 CALCOCO2 CALM1 CAMK2D CAPN15 CARD16 CARD19 CASK CASP8 CAVIN1 CAVIN3 CBL CBLB CBLC CBR1 CBR3 CBX5 CCDC50 CCDC92 CCDC93 CCZ1B CD2 CD2AP CDC20 CDC27 CDC34 CDC42 CDC42SE2 CDC45 CDC6 CDCA3 CDH2 CDH22 CDIP1 CDK17 CDKN2A CDKN2C CDY1B CENPE CENPH CEP164 CEP192 CEP55 CEP78 CEP83 CERS2 CETN2 CFAP36 CHCHD3 CHD3 CHEK1 CHGA CHP1 CHRAC1 CHUK CIAO1 CIRBP CLN8 CLNS1A CLU CMSS1 CNP COL1A1 COMMD9 COPB1 COPS2 COPS3 COPS6 COPS7B COPS8 COQ8A COX11 COX17 CPSF1 CPT1A CRACD CSRP2 CTBP2 CTNNB1 CTRC CUEDC1 CUEDC2 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CYLD DAXX DAZAP2 DCAF10 DCUN1D1 DDI1 DDI2 DDX19B DDX28 DDX50 DECR2 DENR DESI1 DHX15 DHX8 DIABLO DLGAP4 DMBT1 DMBX1 DNAH7 DNAJA1 DNAJA2 DNAJB2 DNAJC3 DNASE2B DNMBP DNMT1 DOCK6 DPH1 DPY30 DTX2 EBI3 ECD ECE2 EFS EGFL7 EIF3A EIF3H EIF3I EIF4E2 ELL ELOVL5 EME2 ENDOG EP300 EPHX1 EPN2 EPN3 EPS15 EPS15L1 ERC1 ERCC6 ERGIC2 ERVK13-1 ETF1 ETS2 EXO5 EXOSC8 EXT2 EYA4 FAAP20 FAF1 FAF2 FAM120B FAM162A FAM168A FAM3A FAN1 FARP2 FAT1 FBH1 FBXL15 FBXO21 FBXO3 FBXO30 FBXO44 FCHO2 FETUB FGA FIS1 FLOT1 FLOT2 FOXF1 FSHR FTL FYB1 FZR1 GADD45GIP1 GAR1 GARNL3 GBE1 GBF1 GCAT GFPT2 GFUS GGA1 GGA3 GIGYF2 GLA GLG1 GLIS3 GNB4 GPC1 GRB2 GRIPAP1 GTF2H1 GTF2H3 GTF2H4 GTF2I GTF2IRD1 GTF3C1 GTF3C3 GTPBP6 GTSE1 H2AC20 H2BC21 HACD1 HACD2 HADHA HADHB HAVCR1 HBS1L HDAC1 HDAC2 HDAC5 HDAC6 HDAC7 HECW1 HERC1 HERC3 HERC4 HGS HIP1 HIP1R HLA-C HLTF HMGB1 HMGCL HMGN2 HNRNPA0 HNRNPM HPDL HPS6 HRNR HSBP1 HSD17B11 HSF1 HSPA8 HSPG2 HTRA2 HUWE1 HYDIN HYDIN2 ID1 IDE IGF1R IKBIP IKBKB IKBKG ILF3 IMMT IMPACT ING1 INO80B-WBP1 INPPL1 INTS14 IQGAP3 IRS1 ISX ITCH ITGAV ITSN1 ITSN2 JOSD1 JOSD2 JPH1 JUN KANK2 KATNAL2 KCMF1 KCTD10 KCTD7 KDM3B KDSR KEAP1 KEL KHDRBS1 KHNYN KIAA0586 KIF21B KIF22 KIFC3 KLHDC3 KLHL11 KLHL13 KLHL28 KLHL7 KMT2D KRT72 LACTB LAMA1 LAMA5 LAMB1 LAMC1 LANCL1 LANCL2 LAPTM5 LARP1B LETMD1 LIMA1 LINC02593 LLGL1 LNPK LRR1 LRRC41 LRSAM1 LSM4 LTF LTN1 MACF1 MAD1L1 MALT1 MAP2K4 MAP2K5 MAP3K7 MAP4 MAP7 MAP7D1 MAP7D3 MAPK14 MAPKAP1 MAPRE2 MARCHF1 MARCHF2 MARCHF4 MARCHF6 MARCHF7 MARCHF8 MAVS MBNL1 MBOAT7 MDM2 MDM4 MDN1 MED1 MED15 MED20 MED9 METTL13 MFF MIA3 MIB2 MICOS13 MICU1 MICU2 MINDY1 MINDY2 MINDY3 MINDY4 MLLT11 MNAT1 MOCOS MORC2 MORC3 MPC1 MRM2 MRPL1 MRPL10 MRPL12 MRPL18 MRPL21 MRPL37 MRPL38 MRPL40 MRPS12 MRPS16 MRPS2 MRPS22 MRPS23 MRPS25 MRPS28 MRPS7 MRPS9 MSANTD4 MTCH1 MTERF4 MTMR14 MTNAP1 MTO1 MTURN MTUS2 MUC16 MUC5B MUL1 MVB12A MVP MYCBP MYL1 MYL3 MYO6 N4BP1 NAA10 NAP1L4 NAT10 NBPF1 NBPF10 NBPF11 NBPF12 NBPF14 NBPF8 NBPF9 NBR1 NCAPG2 NCK2 NCKAP5L NCOA6 NCOR2 NDC1 NDUFB9 NDUFS2 NDUFS8 NEDD4 NEDD4L NEK8 NEK9 NEU1 NEURL3 NFIA NFIC NFX1 NGLY1 NHERF2 NIPSNAP1 NIPSNAP2 NOSIP NPFFR1 NPLOC4 NPM1 NPRL3 NPTN NR2F1 NSFL1C NSMCE1 NSUN4 NT5C1B NUDCD1 NUDT9 NUP155 NUP37 NXPH3 NXPH4 OGT OPA3 OPLAH OPRM1 OR7G3 OSBPL2 OSBPL8 OTOG OTUB1 OTUB2 OTUD1 OTUD3 OTUD4 OTUD5 OTUD6A OTUD6B OTUD7A OTUD7B OTULIN P3H2 P4HTM PABIR2 PABPC4 PARD3 PARN PARP10 PARP2 PBK PBX1 PCBP2 PCIF1 PCMTD1 PCNA PDCD6 PDE12 PDLIM2 PDPK1 PDS5A PEDS1 PEF1 PEG10 PELI1 PEX16 PFAS PHF10 PHF20L1 PHLDA2 PHPT1 PIH1D1 PIK3C2B PINK1 PISD PITPNA PLAA PLBD2 PLEC PLEKHB2 PLSCR4 PML PMS2 PNKD PNPLA6 POLE2 POLH POLI POLR2C POLRMT POMK POP5 PPA1 PPARG PPARGC1A PPL PPM1D PPP1CA PPP1R10 PPP1R7 PPP2CA PPP2CB PPP2R1B PPP2R2D PPP2R3B PPP3CA PPP6R3 PRAME PRDX4 PRKAA2 PRKAR1B PRKCI PRKCZ PRKN PRMT5 PRMT7 PRPF38A PRPF8 PRPS2 PRR23B PRSS23 PSD3 PSIP1 PSMA6 PSMD10 PSMD13 PSMD14 PSMD4 PSMD6 PSMD7 PSMD8 PSPH PTH1R PTOV1 PTPN2 PUS7L QSOX2 R3HDM4 RAB30 RAB3GAP2 RABEP1 RAC1 RAD18 RAD23A RAD23B RAG1 RAMAC RAP1GDS1 RASAL2 RASIP1 RASSF8 RB1CC1 RBCK1 RBMS2 RC3H2 RCHY1 RCOR1 RECQL RELCH REPIN1 REV1 RFC1 RFWD3 RGPD3 RGS2 RHBDD3 RHOF RHOG RIF1 RIGI RIOK1 RIOK3 RIPK2 RLIM RNASET2 RNF11 RNF111 RNF114 RNF115 RNF123 RNF125 RNF126 RNF138 RNF144A RNF144B RNF145 RNF151 RNF166 RNF168 RNF169 RNF181 RNF182 RNF2 RNF213 RNF216 RNF31 RNF38 RNF4 RNF5 RPL12 RPL23 RPL24 RPL37 RPL39P5 RPL7L1 RPN1 RPP30 RPS14 RPS15 RPS23 RPS29 RPS3 RPS6KB1 RSPH1 RTF1 RTF2 RTL8B RTL8C RTTN RYBP SAMM50 SARS2 SART1 SBF2 SCAF1 SCD SDC1 SDC2 SDC4 SDCBP SDF2 SDK1 SDR39U1 SEC23B SEMA3F SEPTIN1 SEPTIN7P2 SETD7 SETX SF3B5 SFPQ SGK1 SGPP1 SH3KBP1 SHARPIN SHKBP1 SHROOM3 SLC25A40 SLC27A2 SLC30A9 SLC31A1 SLC38A5 SLC5A6 SLFN5 SLIT2 SLX4 SLX9 SMAD1 SMU1 SMURF1 SMURF2 SMYD4 SNCA SNF8 SNRNP25 SNRPA SNTB2 SNTG1 SNX27 SOCS5 SPAG1 SPATA2 SPECC1L SPOCK1 SPRTN SREK1IP1 SRP14 SRP9 SRPRB SRSF7 SRSF8 SRXN1 STAMBP STAMBPL1 STON2 STRADB STUB1 STX3 SUCLG1 SUMF1 SUN5 SUZ12 SYDE1 SYPL1 TAB1 TAB2 TAB3 TAC3 TAF2 TAF6L TAPBP TAX1BP1 TBC1D15 TBC1D17 TBC1D2 TBC1D5 TBK1 TBXAS1 TCAF1 TCEAL1 TCHH TCOF1 TCP10L3 TDP1 TDRD3 TEDC1 TENT4A TFDP1 TGFB1 THBS2 THG1L THYN1 TIAM1 TIMP1 TK1 TK2 TMED3 TMEM120A TMEM126B TMEM132A TMEM160 TMEM201 TMEM223 TMX3 TNFAIP3 TNFAIP6 TNIP1 TNIP2 TNIP3 TNK1 TNK2 TNNC1 TNRC6A TNRC6C TOM1 TOM1L1 TOM1L2 TOP1MT TOP2B TOPORS TOR1AIP2 TOR4A TP53BP2 TPD52 TPRG1L TRAF2 TRAF3IP2 TRAF4 TRAF5 TRAF6 TRAFD1 TRAM1 TRAPPC2L TRIM17 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM32 TRIM36 TRIM39 TRIM44 TRIM5 TRIP12 TRIP4 TRMT2A TRMU TRPT1 TSG101 TSR3 TTC28 TTC36 TTF2 TUBA3C TUBA3D TUBA4A TUBAL3 TUBGCP2 TWNK TXNDC15 TYSND1 UBA1 UBA2 UBA6 UBAC1 UBAC2 UBAP1 UBAP2 UBASH3A UBASH3B UBE2A UBE2C UBE2D1 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2G1 UBE2G2 UBE2J1 UBE2J2 UBE2L3 UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2T UBE2V1 UBE2V2 UBE3A UBFD1 UBL7 UBQLN1 UBQLN2 UBQLN4 UBR4 UBXN1 UBXN2B UBXN6 UBXN7 UCHL1 UCHL5 UEVLD UFD1 UGP2 UHRF1 UIMC1 ULK1 ULK3 UNC79 UNC93B3 UQCRQ USP1 USP10 USP11 USP12 USP13 USP14 USP15 USP16 USP17L2 USP19 USP2 USP21 USP22 USP24 USP25 USP27X USP28 USP3 USP30 USP31 USP32 USP33 USP34 USP35 USP37 USP38 USP4 USP40 USP42 USP45 USP46 USP47 USP48 USP53 USP54 USP6 USP7 USP8 USP9X USP9Y VANGL1 VBP1 VCF1 VCP VCPIP1 VIM VPS16 VPS25 VPS28 VPS36 VPS37A VPS37B VPS37C VPS50 WAC WARS1 WBP2 WDR33 WDR48 WDR5 WDR54 WDR6 WDR77 WFDC8 WRNIP1 WWC1 WWP1 WWP2 XIAP XPNPEP1 XRCC5 XRCC6 YAF2 YARS2 YIPF5 YME1L1 YOD1 YWHAB YWHAG YWHAZ ZBTB1 ZC3H12A ZC3H14 ZCCHC14 ZCWPW2 ZFAND2B ZFAND3 ZFAND5 ZFAND6 ZFYVE16 ZFYVE9 ZHX1 ZNF146 ZNF148 ZNF213 ZNF451 ZNF705G ZNF716 ZNF787 ZNF792 ZNRD2 ZNRF1 ZNRF2 ZRANB1 ZRANB2 ZRANB3 ZUP1 ZWILCH	223 interacting genes: AMBRA1 AMFR ANAPC11 AREL1 ARIH1 ARIH2 ARK2C ATXN3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRCA1 CADPS2 CBL CBLC CHFR CNOT4 CRBN CSNK2A1 CUL2 CUL4B DBN1 DCAF1 DCUN1D1 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL12 FBXL2 FBXO2 FBXO25 FBXO4 FBXO7 FBXW10 FBXW11 FBXW8 FOCAD FZR1 H2AC4 HDAC6 HECTD1 HECTD3 HECW1 HECW2 HERC1 HERC2 HSP90AB1 HSPA1A IKBKG ITCH KAT2B KDM1B KLHL3 LRSAM1 MAEA MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEX3B MEX3C MGRN1 MIB1 MID1 MID2 MKRN1 MKRN3 MSL1 MSL2 MUL1 MYCBP2 MYLIP NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NHLRC1 NOSIP OTUB1 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PCNA PDCD5 PELI1 PJA1 PJA2 POLL POLM PPP4C PRPF19 RABGEF1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RMND5B RNF103 RNF111 RNF113A RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF14 RNF150 RNF166 RNF167 RNF168 RNF181 RNF185 RNF19B RNF2 RNF213 RNF216 RNF220 RNF26 RNF31 RNF34 RNF38 RNF4 RNF41 RNF43 RNF5 RNF8 RNFT1 RPLP1 RSPRY1 SAT1 SH3RF1 SIAH1 SIAH2 SMURF1 SMURF2 STAM2 STAU1 STK25 STUB1 SYVN1 TMEM129 TOPORS TRAF6 TRAIP TRIM10 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM33 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM58 TRIM62 TRIM63 TRIM68 TRIM69 TRIM7 TRIM8 TUBA1A UBA1 UBA6 UBASH3B UBC UBE2O UBE3A UBE3C UBE4A UBE4B UBOX5 UBR5 UFM1 UHRF1 USP7 UVSSA VHL WSB1 WWP1 WWP2 XIAP XPNPEP1 ZNF598 ZNRF1 ZNRF2 ZNRF4
Entrez ID		7316	7323
HPRD ID		07038	04269
Ensembl ID		ENSG00000150991	ENSG00000109332
Uniprot IDs		P0CG48	D6RAH7 P61077
PDB IDs		1C3T 1CMX 1D3Z 1F9J 1FXT 1G6J 1GJZ 1NBF 1OGW 1Q5W 1S1Q 1SIF 1TBE 1UBI 1UBQ 1UD7 1XD3 1XQQ 1YX5 1YX6 1ZGU 2AYO 2BGF 2DEN 2FUH 2G45 2GBJ 2GBK 2GBM 2GBN 2GBR 2GMI 2HTH 2IBI 2J7Q 2JF5 2JRI 2JY6 2JZZ 2K25 2K6D 2K8B 2K8C 2KDF 2KHW 2KJH 2KLG 2KN5 2KX0 2L3Z 2LD9 2LVO 2LVP 2LVQ 2LZ6 2MBO 2MBQ 2MCN 2MI8 2MJ5 2MOR 2MRE 2MWS 2N2K 2NR2 2O6V 2OJR 2PE9 2PEA 2RR9 2RU6 2W9N 2WDT 2XEW 2Y5B 2Z59 2ZCB 2ZVN 2ZVO 3A33 3ALB 3AUL 3B08 3B0A 3BY4 3C0R 3DVG 3DVN 3EEC 3EFU 3EHV 3H7P 3H7S 3HM3 3I3T 3IFW 3IHP 3JSV 3JVZ 3JW0 3K9O 3K9P 3KVF 3KW5 3LDZ 3MHS 3MTN 3N30 3N32 3N3K 3NS8 3O65 3OFI 3OJ3 3OJ4 3ONS 3PRM 3PT2 3PTF 3Q3F 3RUL 3TMP 3U30 3UGB 3V6C 3V6E 3VFK 3VUW 3VUX 3VUY 3WXE 3WXF 3ZLZ 3ZNH 3ZNI 3ZNZ 4AP4 4AUQ 4BOS 4BOZ 4BVU 4DDG 4DDI 4DHJ 4DHZ 4FJV 4HK2 4HXD 4I6L 4I6N 4IG7 4IUM 4JQW 4K1R 4K7S 4K7U 4K7W 4KSK 4KSL 4LCD 4LDT 4MDK 4MM3 4MSM 4MSQ 4NQK 4UN2 4V3K 4V3L 4WZP 4XOK 4XOL 4ZQS 5A5B 5AF4 5AF5 5AF6 5AIT 5AIU 5B83 5C7J 5C7M 5E6J 5H07 5NL4 5NLF 5NLI 5NMC 5OE7 5OHV 5OXH 5OXI 5UDH 5WQ4 5ZQ3 5ZQ4 5ZQ5 5ZQ6 5ZQ7 6A43 6A44 6AQR 6B7M 6B7O 6EQI 6K2U 6KBE 6N13 6N6R 6NQA 6NXK 6OI4 6P5B 6Q00 6QML 6RYA 6S53 6SQR 6T7F 6T9L 6TNF 6TTU 6TUV 6TXB 6ULH 6UMP 6UMS 6UPU 6V5D 6VAE 6VAF 6VEN 6W9D 6W9R 6W9S 6WJD 6WKR 6WTG 6Z7V 7B5L 7B5M 7B5N 7BBD 7BBF 7BXG 7EAL 7EAO 7EB9 7JXV 7K6P 7K6Q 7KEO 7M4M 7M4N 7M4O 7MEX 7MIC 7MYF 7NPI 7OWD 7R70 7TV4 7UV5 7UYH 7YUI 7ZF1 7ZJ3 8A9J 8A9K 8ADB 8AMS 8B3G 8B3I 8E7O 8EAZ 8EB0 8FTQ 8JRT 8JTI 8K6E 8K6F 8K6I 8K6R 8K6V 8OFF 8PJN 8PMQ 8PQL 8Q7R 8R5H 8RX0 8SSI 8ST7 8ST8 8ST9 8SVF 8T48 8U5H 9D1I 9D1Y 9D1Z 9D8P 9DBY 9DDE 9DG3 9EBS 9EGV 9EGW 9FCI 9FCJ 9FJ3 9FJ4	1X23 2FUH 3L1Z 3RPG 3UGB 4BVU 4R8P 4S3O 5EGG 5IFR 6CP0 6T7F 7JZV 7LYB 8AMS 8GRQ 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8X7I 8X7J 8X7K 9IPU
GO Terms Enriched among Interactors		Post-translational Protein Modification Protein Metabolic Process Protein Modification Process Macromolecule Metabolic Process Protein Ubiquitination Proteolysis Protein Modification By Small Protein Conjugation Protein Deubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process Cysteine-type Deubiquitinase Activity Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Ubiquitin-protein Transferase Activity Macromolecule Catabolic Process Ubiquitin Protein Ligase Activity Cytosol Protein Catabolic Process Cysteine-type Peptidase Activity Proteasomal Protein Catabolic Process Ubiquitin Binding Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Response To Stress Cytoplasm Polyubiquitin Modification-dependent Protein Binding Regulation Of Post-translational Protein Modification Protein K63-linked Deubiquitination DNA Damage Response Nucleoplasm DNA Repair Peptidase Activity Nucleus Ubiquitin Protein Ligase Binding Regulation Of Protein Ubiquitination Transferase Activity Regulation Of Protein Metabolic Process DNA Metabolic Process Protein K63-linked Ubiquitination Protein K48-linked Deubiquitination K63-linked Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Stability Nucleic Acid Metabolic Process Regulation Of Protein Modification Process K63-linked Deubiquitinase Activity Response To Stress Positive Regulation Of Post-translational Protein Modification Protein Autoubiquitination	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Catabolic Process Metal Ion Binding Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Ubiquitin Ligase Complex Cytoplasm Response To Stress Cellular Response To Stress Protein Monoubiquitination Regulation Of Signal Transduction Ubiquitin-ubiquitin Ligase Activity Regulation Of Signaling Regulation Of Post-translational Protein Modification Regulation Of Cell Communication Ubiquitin Protein Ligase Binding Positive Regulation Of Catabolic Process Ubiquitin Binding Cytosol Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction DNA Damage Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Immune System Process Negative Regulation Of Signaling