C8B

Name	complement C8 beta chain
Structure
Interactors	3 interactors: C5 C8A CLU
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex Extracellular Vesicle
	Molecular Function	Protein-containing Complex Binding
	Biological Process	Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway
Pathways	Terminal pathway of complement Regulation of Complement cascade
Drugs	Zinc Copper Zinc acetate
Diseases	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS	Logical memory (delayed recall) in normal cognition ( 29274321 )
Entrez ID	732
HPRD ID	00410
Ensembl ID	ENSG00000021852
Uniprot IDs	A0A8Q3WL56 B7Z550 B7Z555 P07358
PDB IDs	3OJY 6H03 6H04 7NYC 7NYD 8B0F 8B0G 8B0H
GO Terms Enriched among Interactors ?	Complement Activation, Classical Pathway Complement Activation Other Organism Cell Membrane Membrane Attack Complex Transmembrane Transporter Complex Complement Activation, GZMK Pathway Complement Activation, Alternative Pathway Humoral Immune Response Immune Effector Process Activation Of Immune Response Innate Immune Response Positive Regulation Of Immune Response Defense Response To Other Organism Defense Response To Symbiont Regulation Of Immune Response Receptor Ligand Activity Killing Of Cells Of Another Organism Blood Microparticle Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Positive Regulation Of Immune System Process Response To Other Organism Immune Response Cell Killing Positive Regulation Of Neurofibrillary Tangle Assembly Response To External Biotic Stimulus Defense Response Negative Regulation Of Activation Of Membrane Attack Complex Central Nervous System Myelin Maintenance Immune Complex Clearance Extracellular Space Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Regulation Of Immune System Process Positive Regulation Of Inclusion Body Assembly Negative Regulation Of Complement-dependent Cytotoxicity Neurofibrillary Tangle Positive Regulation Of Amyloid Fibril Formation Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Macrophage Chemotaxis Complement Binding Protein Import Protein-containing Complex Binding Immune System Process Spherical High-density Lipoprotein Particle Signaling Receptor Binding Microglial Cell Proliferation Extracellular Exosome Protein Carrier Chaperone Extracellular Region