SIRPB1

Description		signal regulatory protein beta 1
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane
	Molecular Function	Protein Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation
Pathways		DAP12 interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Systemic lupus erythematosus ( 33536424) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: APOC1 BPIFA1 DAB1 MEOX2 RBFOX1 RBPMS TYROBP
Entrez ID		10326
HPRD ID		04866
Ensembl ID		ENSG00000101307
Uniprot IDs		H9KV29 O00241 Q5TFQ8
PDB IDs		2D9C 2JJU 2JJV
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Phosphatidylcholine Catabolic Process Lateral Motor Column Neuron Migration Cerebellum Structural Organization Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Spinal Cord Motor Neuron Migration Radial Glia Guided Migration Of Purkinje Cell Positive Regulation Of Osteoclast Development Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Receptor Localization To Synapse Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Positive Regulation Of Macrophage Fusion Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA CDS Binding Immune Response In Nasopharyngeal-associated Lymphoid Tissue Immune Response In Gut-associated Lymphoid Tissue Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Triglyceride Catabolic Process Very-low-density Lipoprotein Particle Clearance Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Radial Glia-guided Pyramidal Neuron Migration Somite Specification Microglial Cell Activation Involved In Immune Response Molecular Adaptor Activity Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of RNA Splicing Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Ventral Spinal Cord Development T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Nuclear Stress Granule Phospholipase Inhibitor Activity Regulation Of Osteoclast Development Regulation Of Phosphatidylcholine Metabolic Process Very-low-density Lipoprotein Particle Assembly Cell Migration In Hindbrain Reelin-mediated Signaling Pathway Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Transforming Growth Factor Beta Production Pre-mRNA Intronic Binding MRNA Binding Chylomicron Phospholipid Efflux
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