CTLA4 and CD86

Number of citations of the paper that reports this interaction (PubMedID 12606712)
41

Data Source:
BioGRID (imaging technique, pull down)
HPRD (in vivo, in vitro)

		CTLA4	CD86
Description		cytotoxic T-lymphocyte associated protein 4	CD86 molecule
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Protein Complex Involved In Cell Adhesion	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Centriolar Satellite Extracellular Exosome
	Molecular Function	Protein Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity Receptor Ligand Activity
	Biological Process	Adaptive Immune Response Immune System Process Immune Response DNA Damage Response Negative Regulation Of B Cell Proliferation Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Regulatory T Cell Differentiation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Adaptive Immune Response Immune System Process Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of T Cell Proliferation T Cell Activation B Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of DNA-templated Transcription Lymphocyte Activation Symbiont Entry Into Host Cell Cellular Response To Lipopolysaccharide Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Co-stimulation by CD28 Co-inhibition by CTLA4 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Abatacept Ipilimumab Tremelimumab	Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept Bryostatin 1
Diseases		Graves' disease Allograft rejection Type I diabetes mellitus Hashimoto's thyroiditis
GWAS		Addison's disease ( 33574239) Alopecia areata ( 25608926 20596022) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203 33549134) Celiac disease ( 22057235 30572963 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Graves' disease ( 21841780) Heel bone mineral density ( 30598549) Hypothyroidism ( 22493691 27182965) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602) Myasthenia gravis ( 25643325) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 24390342 30423114 30572963 23143596 19503088) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 19430480 30659077 30572963 25751624 21829393 18978792) Ulcerative colitis ( 26192919) Vitiligo ( 27723757)	Autoimmune thyroid disease ( 32581359) Diffuse large B cell lymphoma ( 25261932) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 21833088 22190364 24076602 27386562 31604244) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)
Interacting Genes		17 interacting genes: AP1M1 AP2M1 CD80 CD86 CTXN3 FYN JAK2 LCK LYN MALL PIK3R1 PPP2R5A PTPN11 STAT5A STAT5B TMEM218 TXK	6 interacting genes: CD28 CD80 CTLA4 ECE2 MARCHF8 PARP1
Entrez ID		1493	942
HPRD ID		00474	03011
Ensembl ID		ENSG00000163599	ENSG00000114013
Uniprot IDs		P16410	A0A0X9R4E0 A8K632 P42081
PDB IDs		1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK 5GGV 5TRU 5XJ3 6RP8 6RPJ 6RQM 6XY2 7CIO 7DV4 7ELX 7SU0 7SU1 8GAB 8HIT 9DQ3	1I85 1NCN 5YXK 8FXX 8FXY 8HXB 8HXC
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Growth Hormone Receptor Signaling Pathway Leukocyte Activation T Cell Activation Lymphocyte Activation Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Interleukin-2 Production Regulation Of Mononuclear Cell Proliferation Regulation Of Immune Response Positive Regulation Of Leukocyte Proliferation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Leukocyte Proliferation Phosphatidylinositol 3-kinase Binding Regulation Of T Cell Proliferation Positive Regulation Of Immune System Process Positive Regulation Of T Cell Proliferation Regulation Of Cell Adhesion Regulation Of Cell Activation Positive Regulation Of Immune Response Protein Tyrosine Kinase Activity Regulation Of Interleukin-2 Production Positive Regulation Of Cytokine Production Interleukin-5-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Differentiation Regulation Of Hemopoiesis Regulation Of Cytokine Production Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Activated T Cell Proliferation Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Differentiation Mononuclear Cell Differentiation Peptide Hormone Receptor Binding Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Lymphocyte Proliferation Regulation Of Lymphocyte Differentiation	Protein Complex Involved In Cell Adhesion Regulation Of Lymphocyte Differentiation Regulation Of DNA Metabolic Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Response To Aldosterone NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of DNA Recombination NAD+-protein-histidine ADP-ribosyltransferase Activity Response To Mineralocorticoid Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Circadian Sleep/wake Cycle NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation T Cell Costimulation Regulation Of T Cell Proliferation Regulation Of B Cell Activation Regulation Of Cell Development Regulation Of Regulatory T Cell Differentiation Regulation Of Lymphocyte Activation Regulation Of Hemopoiesis Positive Regulation Of Interleukin-2 Production Regulation Of T Cell Differentiation Negative Regulation Of Cell Activation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Leukocyte Activation Negative Regulation Of B Cell Activation Activin A Complex Androst-4-ene-3,17-dione Biosynthetic Process Thyrotropin-releasing Hormone Activity Negative Regulation Of Immune System Process Coreceptor Activity Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Lymphocyte Differentiation Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Myofibroblast Differentiation Regulation Of Cell Differentiation NAD+-protein-serine ADP-ribosyltransferase Activity Regulation Of Interleukin-2 Production Regulation Of Leukocyte Proliferation Cardiac Fibroblast Cell Development Type II Activin Receptor Binding Inhibin A Complex Positive Regulation Of Ovulation Progesterone Secretion Positive Regulation Of DNA Recombination Regulation Of Behavior Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Activation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?