CTLA4 and CD86

Number of citations of the paper that reports this interaction (PMID 7694153)
109

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		CTLA4	CD86
Gene Name		cytotoxic T-lymphocyte-associated protein 4	CD86 molecule
Image
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Receptor Activity Receptor Binding Protein Binding Coreceptor Activity
	Biological Process	Immune Response Cellular Response To DNA Damage Stimulus Negative Regulation Of B Cell Proliferation T Cell Costimulation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway	Response To Yeast Toll-like Receptor Signaling Pathway T Cell Proliferation Involved In Immune Response Negative Regulation Of T Cell Anergy Immune Response Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Aging Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Viral Process T Cell Costimulation Response To Interferon-gamma Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation Response To Drug Myeloid Dendritic Cell Differentiation Positive Regulation Of Lymphotoxin A Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-4 Biosynthetic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Metal Ion Cellular Response To Cytokine Stimulus
Pathways		Costimulation by the CD28 family CTLA4 inhibitory signaling Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Costimulation by the CD28 family Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CTLA4 inhibitory signaling CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling CD28 dependent Vav1 pathway Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs		Alpha-D-Mannose	Antithymocyte globulin Abatacept Belatacept
Diseases
GWAS		Alopecia areata ( 20596022) Celiac disease ( 20190752) Graves' disease ( 21841780) Hypothyroidism ( 22493691) Rheumatoid arthritis ( 20453842 19503088) Type 1 diabetes ( 19430480 18978792) Type 1 diabetes autoantibodies ( 21829393)	Multiple sclerosis ( 22190364 21833088)
Protein-Protein Interactions		14 interactors: AP1M1 AP2M1 CD80 CD86 FYN JAK2 LCK LYN PIK3R1 PPP2R5A PTPN11 STAT5A STAT5B TXK	6 interactors: CD28 CD80 CTLA4 ECE2 MARCH8 PARP1
Entrez ID		1493	942
HPRD ID		00474	03011
Ensembl ID		ENSG00000163599	ENSG00000114013
Uniprot IDs		P16410	A8K632 P42081
PDB IDs		1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK	1I85 1NCN
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of T Cell Activation Regulation Of Immune System Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Activation T Cell Costimulation Regulation Of T Cell Activation Regulation Of Immune Response Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Immune System Process Leukocyte Activation Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Growth Hormone Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Peptide Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Hemopoiesis Positive Regulation Of Immune Response Neurotrophin TRK Receptor Signaling Pathway Lymphocyte Activation Peptidyl-tyrosine Autophosphorylation Cell Activation Response To Growth Hormone Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune System Development Response To Peptide Hormone Positive Regulation Of Interleukin-2 Biosynthetic Process Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Response To Peptide T Cell Aggregation Fc Receptor Signaling Pathway T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Phosphatidylinositol-mediated Signaling Regulation Of Cytokine Production Leukocyte Cell-cell Adhesion Viral Process Cellular Response To Organic Substance	T Cell Costimulation Regulation Of T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Interleukin-2 Production Immune System Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Cytokine Biosynthetic Process Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Proliferation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cytokine Biosynthetic Process Regulation Of Cell Adhesion Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Immune Response Regulation Of T Cell Differentiation Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Regulation Of Lymphocyte Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Growth Rate Protein Poly-ADP-ribosylation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Adaptive Immune Response Positive Regulation Of Immune System Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Regulatory T Cell Differentiation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T-helper 1 Cell Differentiation
Tagcloud ?		airway allergic asthma b7 bal blocking bronchoalveolar cd28 challenge challenges costimulation costimulatory engagement eosinophils eu hyperresponsiveness ige igg immunosuppressive infiltration inhalation lavage lymphocyte methacholine ovalbumin parabronchial sensitized tcr	amixl atl bc blast burkitt cd54 cd58 cd80 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
Tagcloud (Difference) ?		airway allergic asthma b7 bal blocking bronchoalveolar cd28 challenge challenges costimulation engagement eosinophils eu hyperresponsiveness ige igg immunosuppressive infiltration inhalation lavage lymphocyte methacholine ovalbumin parabronchial sensitized tcr	amixl atl bc blast burkitt cd54 cd58 cd80 cll cml crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
Tagcloud (Intersection) ?		costimulatory