CTLA4 and STAT5B

Number of citations of the paper that reports this interaction (PMID 16476059)
2

Data Source:
HPRD (in vivo, two hybrid)

		CTLA4	STAT5B
Gene Name		cytotoxic T-lymphocyte-associated protein 4	signal transducer and activator of transcription 5B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Protein Phosphatase Binding Glucocorticoid Receptor Binding Protein Dimerization Activity
	Biological Process	Immune Response Cellular Response To DNA Damage Stimulus Negative Regulation Of B Cell Proliferation T Cell Costimulation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway	Allantoin Metabolic Process Luteinization Response To Hypoxia Natural Killer Cell Differentiation Liver Development Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process Acute-phase Response JAK-STAT Cascade Female Pregnancy Lactation Regulation Of Steroid Metabolic Process Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus T Cell Differentiation In Thymus Prolactin Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Progesterone Metabolic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Creatinine Metabolic Process Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Cellular Component Movement JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Costimulation by the CD28 family CTLA4 inhibitory signaling Adaptive Immune System	Signaling by PDGF Signaling by FGFR in disease Cytokine Signaling in Immune system Signaling by ERBB4 Signaling by SCF-KIT Signaling by Interleukins Nuclear signaling by ERBB4 Downstream signal transduction Signaling by FGFR1 mutants Interleukin-7 signaling Signaling by FGFR mutants Interleukin-2 signaling Prolactin receptor signaling Signaling by FGFR1 fusion mutants Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Growth hormone receptor signaling
Drugs		Alpha-D-Mannose	Dasatinib
Diseases
GWAS		Alopecia areata ( 20596022) Celiac disease ( 20190752) Graves' disease ( 21841780) Hypothyroidism ( 22493691) Rheumatoid arthritis ( 20453842 19503088) Type 1 diabetes ( 19430480 18978792) Type 1 diabetes autoantibodies ( 21829393)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		14 interactors: AP1M1 AP2M1 CD80 CD86 FYN JAK2 LCK LYN PIK3R1 PPP2R5A PTPN11 STAT5A STAT5B TXK	49 interactors: AFTPH APP CBL CD247 CENPJ CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT MAPK1 NCOR2 NMI NR3C1 PDGFRA PDGFRB POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA SERTAD1 SHC1 SRC STAP2 STAT1 STAT3 STAT5A TEK TFG
Entrez ID		1493	6777
HPRD ID		00474	05037
Ensembl ID		ENSG00000163599	ENSG00000173757
Uniprot IDs		P16410	P51692
PDB IDs		1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of T Cell Activation Regulation Of Immune System Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Activation T Cell Costimulation Regulation Of T Cell Activation Regulation Of Immune Response Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Immune System Process Leukocyte Activation Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Growth Hormone Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Peptide Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Hemopoiesis Positive Regulation Of Immune Response Neurotrophin TRK Receptor Signaling Pathway Lymphocyte Activation Peptidyl-tyrosine Autophosphorylation Cell Activation Response To Growth Hormone Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune System Development Response To Peptide Hormone Positive Regulation Of Interleukin-2 Biosynthetic Process Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Response To Peptide T Cell Aggregation Fc Receptor Signaling Pathway T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Phosphatidylinositol-mediated Signaling Regulation Of Cytokine Production Leukocyte Cell-cell Adhesion Viral Process Cellular Response To Organic Substance	Cellular Response To Organic Substance Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Response To Hormone Regulation Of MAPK Cascade Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Response To Cytokine Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Phosphorylation Regulation Of Signal Transduction Growth Hormone Receptor Signaling Pathway Regulation Of Protein Phosphorylation Cellular Response To Hormone Stimulus Cellular Response To Growth Hormone Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Immune Response Signaling Regulation Of Phosphorus Metabolic Process Signal Transduction JAK-STAT Cascade Positive Regulation Of MAPK Cascade Defense Response Cell Communication Regulation Of Signaling Cellular Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Immune System Process Cellular Response To Cytokine Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Organ Development Cellular Response To Peptide Response To Growth Hormone Positive Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Protein Metabolic Process Response To Peptide Hormone Positive Regulation Of Transferase Activity Innate Immune Response
Tagcloud ?		airway allergic asthma b7 bal blocking bronchoalveolar cd28 challenge challenges costimulation costimulatory engagement eosinophils eu hyperresponsiveness ige igg immunosuppressive infiltration inhalation lavage lymphocyte methacholine ovalbumin parabronchial sensitized tcr	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat2 stats yeast
Tagcloud (Difference) ?		airway allergic asthma b7 bal blocking bronchoalveolar cd28 challenge challenges costimulation costimulatory engagement eosinophils eu hyperresponsiveness ige igg immunosuppressive infiltration inhalation lavage lymphocyte methacholine ovalbumin parabronchial sensitized tcr	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat2 stats yeast
Tagcloud (Intersection) ?