RBBP7 and SALL2

Number of citations of the paper that reports this interaction (PubMedID 21228219)
51

Data Source:
BioGRID (enzymatic study)

		RBBP7	SALL2
Description		RB binding protein 7, chromatin remodeling factor	spalt like transcription factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol NuRD Complex NURF Complex ESC/E(Z) Complex Sin3-type Complex ATPase Complex	Nucleus
	Molecular Function	RNA Binding Protein Binding Histone Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Brain Development Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Response To Steroid Hormone Cellular Heat Acclimation Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation	Eye Development Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II System Development
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HATs acetylate histones RMTs methylate histone arginines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Neddylation Transcriptional Regulation by E2F6 HCMV Early Events Potential therapeutics for SARS Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Femur bone mineral density x serum urate levels interaction ( 34046847) Fruit consumption ( 32066663) Response to Homoharringtonine (cytotoxicity) ( 25628645) Tuberculosis ( 30713548)
Interacting Genes		32 interacting genes: APPL1 APPL2 BRCA1 BRMS1 BRMS1L BUB3 CREBBP CRYAA CYTOR DDB1 DHX30 ERCC6 ESR1 H3-4 H3C1 H4C1 HDAC1 HDAC2 ING1 MBD3 MTA2 NR2E3 PRKAA2 RB1 RBBP4 RBP1 SALL2 SAP30 SIN3A SUMO2 SUV39H1 TWIST1	8 interacting genes: ADAMTSL4 CEP76 CUL4A CUL4B DDB1 EWSR1 RBBP7 ZMIZ2
Entrez ID		5931	6297
HPRD ID		04231	03743
Ensembl ID		ENSG00000102054	ENSG00000165821
Uniprot IDs		Q16576 Q6FHQ0	B4DK65 E7EW59 F5H433 Q9Y467
PDB IDs		3CFS 3CFV 7M3X
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Chromatin Remodeling Chromatin Organization Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Population Maintenance Nucleus Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process NuRD Complex Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Histone Deacetylase Complex Regulation Of Gene Expression Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Fate Specification Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Rhythmic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Developmental Process Histone Deacetylase Binding Negative Regulation Of Developmental Process Protein-containing Complex Heterochromatin Formation Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Nucleosomal DNA Binding Chromatin Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Fate Commitment Negative Regulation Of Gene Expression, Epigenetic Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Migration Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cul4B-RING E3 Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Cellular Response To UV UV-damage Excision Repair Cellular Response To Light Stimulus Cullin-RING Ubiquitin Ligase Complex Base-excision Repair, AP Site Formation Response To UV Cellular Response To Radiation Positive Regulation Of Protein Catabolic Process Protein Modification By Small Protein Conjugation DNA Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Type I Interferon-mediated Signaling Pathway Post-translational Protein Modification Response To Light Stimulus Positive Regulation Of Cell Cycle G1/S Phase Transition Damaged DNA Binding Regulation Of Mitotic Cell Cycle Phase Transition Interferon-mediated Signaling Pathway Pigment Cell Development Regulation Of Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Ribosome Biogenesis DNA Repair Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Mitotic Cell Cycle Phase Transition Protein Catabolic Process Protein Ubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Nucleoplasm WD40-repeat Domain Binding Cellular Heat Acclimation
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