RBBP7 and TWIST1

Number of citations of the paper that reports this interaction (PubMedID 20714342)
51

Data Source:
BioGRID (pull down)

		RBBP7	TWIST1
Description		RB binding protein 7, chromatin remodeling factor	twist family bHLH transcription factor 1
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GO Annotations	Cellular Component	Histone Deacetylase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol NuRD Complex NURF Complex ESC/E(Z) Complex Sin3-type Complex ATPase Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Binding Protein Binding Histone Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Protein Dimerization Activity E-box Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Brain Development Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Response To Steroid Hormone Cellular Heat Acclimation Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation In Utero Embryonic Development Neuron Migration Neural Tube Closure Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macrophage Cytokine Production Cell Differentiation Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Positive Regulation Of Fatty Acid Beta-oxidation Developmental Process Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Outer Ear Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of Skeletal Muscle Tissue Development Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Stem Cell Differentiation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cranial Suture Morphogenesis Embryonic Camera-type Eye Formation Eyelid Development In Camera-type Eye Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cellular Response To Hypoxia Positive Regulation Of Monocyte Chemotactic Protein-1 Production Energy Homeostasis Negative Regulation Of MiRNA Transcription Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Cell Motility Negative Regulation Of Cellular Senescence Negative Regulation Of Double-strand Break Repair Cell Proliferation Involved In Heart Valve Development Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HATs acetylate histones RMTs methylate histone arginines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Neddylation Transcriptional Regulation by E2F6 HCMV Early Events Potential therapeutics for SARS Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Interleukin-4 and Interleukin-13 signaling Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Nuclear events stimulated by ALK signaling in cancer Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases			Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Refractive error ( 32231278)	Coronary artery disease ( 33020668 32469254) Diastolic blood pressure ( 30578418) Diisocyanate-induced asthma ( 25918132) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Large artery stroke (TOAST classification) ( 32047268) Male-pattern baldness ( 29146897) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pulse pressure ( 29403010 30487518 27841878 30578418) Systolic blood pressure ( 27841878 30487518 30578418) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		32 interacting genes: APPL1 APPL2 BRCA1 BRMS1 BRMS1L BUB3 CREBBP CRYAA CYTOR DDB1 DHX30 ERCC6 ESR1 H3-4 H3C1 H4C1 HDAC1 HDAC2 ING1 MBD3 MTA2 NR2E3 PRKAA2 RB1 RBBP4 RBP1 SALL2 SAP30 SIN3A SUMO2 SUV39H1 TWIST1	30 interacting genes: BCL6 CHD4 EP300 FBXO45 GLI3 HOXA5 IKBKB KAT2B KMT5A KPNA5 KPNA7 MUC1 MYOD1 NEIL3 PTEN RBBP7 RELA SPOP STAT3 TCF3 TCF4 TP53 TRIB3 TRIM28 USP13 USP18 YY1 YY2 ZIC3 ZRANB1
Entrez ID		5931	7291
HPRD ID		04231	03374
Ensembl ID		ENSG00000102054	ENSG00000122691
Uniprot IDs		Q16576 Q6FHQ0	Q15672
PDB IDs		3CFS 3CFV 7M3X	2MJV 8OSB
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Chromatin Remodeling Chromatin Organization Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Population Maintenance Nucleus Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process NuRD Complex Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Histone Deacetylase Complex Regulation Of Gene Expression Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Fate Specification Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Rhythmic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Developmental Process Histone Deacetylase Binding Negative Regulation Of Developmental Process Protein-containing Complex Heterochromatin Formation Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Nucleosomal DNA Binding Chromatin Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Fate Commitment Negative Regulation Of Gene Expression, Epigenetic Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Migration Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Chromatin Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation Cellular Response To Stress DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of Primary Metabolic Process Regulation Of Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Response To Stress Regulation Of Metabolic Process Chromatin Organization Chromatin Remodeling Regulation Of Cellular Response To Stress Cis-regulatory Region Sequence-specific DNA Binding Anterior/posterior Pattern Specification Chromatin DNA Binding DNA Damage Response
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