TUBG1 and RND2

		TUBG1	RND2
Description		tubulin gamma 1	Rho family GTPase 2
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Condensed Nuclear Chromosome Gamma-tubulin Complex Gamma-tubulin Ring Complex Nucleus Cytoplasm Centrosome Centriole Spindle Polar Microtubule Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton Cell Leading Edge Ciliary Basal Body Neuron Projection Apical Part Of Cell Recycling Endosome Non-motile Cilium Mitotic Spindle Microtubule	Acrosomal Membrane Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding Microtubule Nucleator Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Microtubule Nucleation Mitotic Spindle Organization Cytoplasmic Microtubule Organization	Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Actin Cytoskeleton Organization Collateral Sprouting Positive Regulation Of Collateral Sprouting
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	RND2 GTPase cycle
Drugs		Vinblastine
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)	Coronary artery disease ( 29212778)
Interacting Genes		31 interacting genes: APP BRCA1 CEBPA CNTN2 CPAP CUL4A DDX41 ERCC3 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 OGT PCNT PIK3R1 PLK1 PXN RACGAP1 RACK1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4	5 interacting genes: FNBP1 MEOX2 RACGAP1 UBXN11 VPS4A
Entrez ID		7283	8153
HPRD ID		01853	03332
Ensembl ID		ENSG00000131462	ENSG00000108830
Uniprot IDs		P23258	P52198
PDB IDs		1Z5V 1Z5W 3CB2 6V5V 6V6S 7AS4 7QJ0 7QJ1 7QJ2 7QJ3 7QJ4 7QJ5 7QJ6 7QJ7 7QJ8 7QJ9 7QJA 7QJB 7QJC 7QJD 7QJE 8Q62 8RX1 8VA2 8VRD 8VRJ 8VRK 9H9P
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Cytoskeleton Microtubule Cytoskeleton Organization Cytoskeleton Organization Microtubule Organelle Organization Microtubule Organizing Center Microtubule Nucleation Gamma-tubulin Binding Structural Constituent Of Cytoskeleton Centrosome Regulation Of Cell Cycle Positive Regulation Of Proteolysis Mitotic Cell Cycle Microtubule Cytoskeleton Gamma-tubulin Complex Intracellular Signal Transduction Cytoplasm Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Programmed Cell Death Signal Transduction Supramolecular Fiber Organization Protein Domain Specific Binding Spindle Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Cell Cycle Process Spindle Pole Spindle Midzone Spindle Organization Positive Regulation Of Gene Expression Microtubule Organizing Center Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cell Division Regulation Of Response To Endoplasmic Reticulum Stress Midbody Regulation Of Protein Metabolic Process Microtubule Polymerization Or Depolymerization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Hemopoiesis Regulation Of Cellular Response To Stress Substrate Adhesion-dependent Cell Spreading	Spindle Cytoskeleton Flemming Body Cytokinetic Process Microtubule Nucleator Activity Actomyosin Contractile Ring Contraction Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Cytoskeleton-dependent Cytokinesis Regulation Of Cytokinesis Contractile Ring Contraction Positive Regulation Of Viral Budding Via Host ESCRT Complex Centralspindlin Complex Somite Specification Polar Microtubule Mitotic Cytokinesis Checkpoint Signaling Regulation Of Cell Division Midbody Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Actomyosin Contractile Ring Assembly ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Cytokinesis Mitotic Nuclear Membrane Reassembly ESCRT III Complex Disassembly ESCRT Complex Disassembly Mitotic Spindle Midzone Assembly Gamma-tubulin Ring Complex Gamma-tubulin Complex ATPase Complex Sulfate Transmembrane Transport Spindle Midzone Assembly Cytoplasm Segment Specification Somite Development Microtubule Mitotic Spindle Microtubule Lipid Binding Endosomal Vesicle Fusion Viral Budding From Plasma Membrane Negative Regulation Of Cell Division Vacuolar Membrane Positive Regulation Of Exosomal Secretion Late Endosome To Lysosome Transport Regulation Of Exosomal Secretion Meiotic Spindle Organization Pericentriolar Material Intracellular Cholesterol Transport Viral Budding Via Host ESCRT Complex
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