TUBG1 and WNT3

		TUBG1	WNT3
Description		tubulin gamma 1	Wnt family member 3
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GO Annotations	Cellular Component	Pericentriolar Material Condensed Nuclear Chromosome Gamma-tubulin Complex Gamma-tubulin Ring Complex Nucleus Cytoplasm Centrosome Centriole Spindle Polar Microtubule Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton Cell Leading Edge Ciliary Basal Body Neuron Projection Apical Part Of Cell Recycling Endosome Non-motile Cilium Mitotic Spindle Microtubule	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome Bounding Membrane Of Organelle Wnt Signalosome
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding Microtubule Nucleator Activity	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Protein Domain Specific Binding Receptor Ligand Activity
	Biological Process	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Microtubule Nucleation Mitotic Spindle Organization Cytoplasmic Microtubule Organization	Cell Morphogenesis Mesoderm Formation Gamete Generation Axon Guidance Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Anterior/posterior Pattern Specification Gene Expression Positive Regulation Of Gene Expression Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Neuron Differentiation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Cell Fate Commitment Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Animal Organ Development Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Collateral Sprouting In Absence Of Injury System Development Negative Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Neurogenesis Spemann Organizer Formation At The Anterior End Of The Primitive Streak Canonical Wnt Signaling Pathway Limb Development Limb Bud Formation Head Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Stem Cell Proliferation Midbrain Dopaminergic Neuron Differentiation Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Drugs		Vinblastine
Diseases			Tetra-amelia
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)	A body shape index ( 34021172) Alcohol consumption (drinks per week) ( 30679032) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 30061737) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Cortical surface area (global PC1) ( 32198502) Cortical thickness ( 32963231) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Handedness (non-right-handed vs right-handed) ( 31504236) Hematocrit ( 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29785010) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Male-pattern baldness ( 29146897 28196072) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Nonsyndromic cleft lip with or without cleft palate ( 33898419) Parkinson's disease ( 34064523 21812969 22451204) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Post bronchodilator FEV1 ( 26634245) Reaction time ( 29844566) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		31 interacting genes: APP BRCA1 CEBPA CNTN2 CPAP CUL4A DDX41 ERCC3 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 OGT PCNT PIK3R1 PLK1 PXN RACGAP1 RACK1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4	1 interacting genes: FZD1
Entrez ID		7283	7473
HPRD ID		01853	01318
Ensembl ID		ENSG00000131462	ENSG00000108379
Uniprot IDs		P23258	P56703
PDB IDs		1Z5V 1Z5W 3CB2 6V5V 6V6S 7AS4 7QJ0 7QJ1 7QJ2 7QJ3 7QJ4 7QJ5 7QJ6 7QJ7 7QJ8 7QJ9 7QJA 7QJB 7QJC 7QJD 7QJE 8Q62 8RX1 8VA2 8VRD 8VRJ 8VRK 9H9P	6AHY
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Cytoskeleton Microtubule Cytoskeleton Organization Cytoskeleton Organization Microtubule Organelle Organization Microtubule Organizing Center Microtubule Nucleation Gamma-tubulin Binding Structural Constituent Of Cytoskeleton Centrosome Regulation Of Cell Cycle Positive Regulation Of Proteolysis Mitotic Cell Cycle Microtubule Cytoskeleton Gamma-tubulin Complex Intracellular Signal Transduction Cytoplasm Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Programmed Cell Death Signal Transduction Supramolecular Fiber Organization Protein Domain Specific Binding Spindle Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Cell Cycle Process Spindle Pole Spindle Midzone Spindle Organization Positive Regulation Of Gene Expression Microtubule Organizing Center Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cell Division Regulation Of Response To Endoplasmic Reticulum Stress Midbody Regulation Of Protein Metabolic Process Microtubule Polymerization Or Depolymerization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Hemopoiesis Regulation Of Cellular Response To Stress Substrate Adhesion-dependent Cell Spreading	Polar Microtubule Gamma-tubulin Ring Complex Gamma-tubulin Complex Microtubule Nucleator Activity Wnt Signalosome Midbrain Dopaminergic Neuron Differentiation Autocrine Signaling Astrocyte-dopaminergic Neuron Signaling Hard Palate Development Glial Cell-neuron Signaling Presynapse Assembly Muscular Septum Morphogenesis Membranous Septum Morphogenesis Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Mitotic Spindle Microtubule Wnt Receptor Activity Presynapse Organization Meiotic Spindle Organization Pericentriolar Material Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Microtubule Nucleation Non-motile Cilium Endothelial Cell Differentiation Wnt-protein Binding Frizzled Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Dopaminergic Neuron Differentiation Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Ventricular Septum Morphogenesis Spindle Microtubule Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Condensed Nuclear Chromosome Non-canonical Wnt Signaling Pathway Nuclear Chromosome Segregation Cytoplasmic Microtubule Cell Leading Edge Outflow Tract Morphogenesis Cytoplasmic Microtubule Organization Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Differentiation Cardiac Septum Morphogenesis Muscle Tissue Morphogenesis Regulation Of Stem Cell Differentiation PDZ Domain Binding Apical Part Of Cell Mitotic Spindle Organization
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