TBCE and TBCD

Number of citations: 38 (PubMedID 9265649)
Data Source: HPRD (in vitro)

		TBCE	TBCD
Name		tubulin folding cofactor E	tubulin folding cofactor D
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule	Cytoplasm Centrosome Cytoskeleton Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Lateral Plasma Membrane Anchoring Junction
	Molecular Function	Protein Binding Alpha-tubulin Binding Protein-folding Chaperone Binding	GTPase Activator Activity Protein Binding Beta-tubulin Binding Protein-folding Chaperone Binding
	Biological Process	Microtubule Cytoskeleton Organization Protein Folding Tubulin Complex Assembly Post-chaperonin Tubulin Folding Pathway Mitotic Spindle Organization Axonogenesis Adult Locomotory Behavior Post-embryonic Development Muscle Atrophy Developmental Growth Peripheral Nervous System Neuron Axonogenesis	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Protein Folding Tubulin Complex Assembly Post-chaperonin Tubulin Folding Pathway Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Microtubule Polymerization Adherens Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Bicellular Tight Junction Assembly
Pathways		Post-chaperonin tubulin folding pathway	Post-chaperonin tubulin folding pathway
Diseases		Kenny-Caffey syndrome Hypoparathyroidism-retardation-dysmorphism syndrome; Sanjad-Sakati syndrome	None
GWAS		Adiposity ( 19557161 ) Blood protein levels ( 30072576 ) First year height change in growth hormone-treated short stature ( 32652002 ) Household income (MTAG) ( 31844048 )	Blond vs. brown/black hair color ( 30531825 ) Bone mineral accretion in asthma (oral corticosteroid dose interaction) ( 26025128 ) Mean platelet volume ( 32888494 ) Moderate-to-late spontaneous preterm birth ( 31194736 ) Response to cognitive-behavioural therapy in anxiety and major depressive disorders ( 31123309 )
Novel Interactors		3 novel interactors: EIF2B2 PRDM2 SERTAD3	None recorded
Interacting Genes		4 interacting genes: AKT1 OGT TBCD TUBA4A	14 interacting genes: ACD APP ARL2 COMMD4 DEXI MTDH MTNR1B POLR2I POT1 SMAD9 TBCE TERF1 TUBB XRCC6
Entrez ID		6905	6904
HPRD ID		05381	05227
Ensembl ID		ENSG00000284770	ENSG00000141556
Uniprot IDs		A0A2R8Y6Q1 Q15813	A0A804HI02 A0A804HIN6 A0A804HJ32 A0A804HJU6 A0A804HLI2 Q9BTW9
PDB IDs		4ICU 4ICV	Not available
GO Terms Enriched among Interactors		Regulation Of Translational Initiation Regulation Of Translation TOR Signaling Negative Regulation Of Protein Ubiquitination Translation Negative Regulation Of Translational Initiation Phosphatidylinositol-3,4,5-trisphosphate Binding Response To Heat Positive Regulation Of Translational Initiation Positive Regulation Of TOR Signaling Positive Regulation Of TORC1 Signaling Regulation Of TRNA Methylation Response To Peptide Hormone TORC1 Signaling Translational Initiation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Proteolysis Carbohydrate Homeostasis Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of RNA Biosynthetic Process Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Response To Insulin-like Growth Factor Stimulus Cytoplasmic Translation Response To Temperature Stimulus Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Regulation Of Protein Localization To Cell Periphery Potassium Channel Activator Activity Regulation Of Protein Ubiquitination Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Regulation Of Glucose Metabolic Process Response To Hormone Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of TOR Signaling	Nuclear Telomere Cap Complex Telomeric DNA Binding Shelterin Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Telomere Maintenance RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of Telomere Maintenance Telomere Assembly Regulation Of Telomere Maintenance Via Telomerase Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Double-stranded Telomeric DNA Binding Telomeric D-loop Disassembly Positive Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Nuclear Envelope Lumen Telomeric Loop Disassembly Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Chromosome Organization Negative Regulation Of DNA Metabolic Process DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Establishment Of Protein Localization Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleolus Positive Regulation Of Organelle Organization Maintenance Of Transcriptional Fidelity During Transcription Elongation By RNA Polymerase II Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly