GRM7

Description		glutamate metabotropic receptor 7
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Cortex Membrane Axon Dendrite Asymmetric Synapse Dendritic Shaft Receptor Complex Postsynaptic Membrane Presynaptic Active Zone
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding Glutamate Receptor Activity Adenylate Cyclase Inhibitor Activity Glutamate Binding PDZ Domain Binding Protein Dimerization Activity Serine Binding
	Biological Process	Behavioral Fear Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Sensory Perception Of Sound Negative Regulation Of Glutamate Secretion Regulation Of Synaptic Transmission, Glutamatergic Axon Development Glycosylation
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Glutamic acid
Diseases
GWAS		Acute kidney injury in coronary artery bypass surgery (creatinine rise) ( 26083657) Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) ( 23648065) Airway imaging phenotypes ( 26030696) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Cognitive function in longevity ( 33607172) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Early response to risperidone in schizophrenia ( 26856250) HDL cholesterol levels in HIV infection ( 33109212) Major depressive disorder (broad) ( 20038947) Night sleep phenotypes ( 27126917) Orofacial clefts ( 22419666) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Panic disorder ( 19165232) Personality traits in bipolar disorder ( 21368711) Plasma clusterin levels ( 26545630) Platelet reactivity in response to clopidogrel treatment ( 32472697) Recurrent major depressive disorder ( 29317602) Response to fenofibrate (total cholesterol levels) ( 27002377) Systemic sclerosis ( 30247649) Telomere length ( 30185882) Urate levels in lean individuals ( 25811787) Urinary albumin excretion ( 32277301) Uterine fibroid number (single vs multiple) ( 30196971) Visceral adipose tissue adjusted for BMI ( 22589738)
Novel Interacting Genes		1 novel interacting genes: NGLY1
Interacting Genes		14 interacting genes: CALM1 CALM2 CALM3 FLNA GNAQ GRIP1 GRIPAP1 PICK1 SDCBP TUBA1A TUBA1B TUBA3C TUBA4A TUBA8
Entrez ID		2917
HPRD ID		04979
Ensembl ID		ENSG00000196277
Uniprot IDs		B2R693 B7ZKK0 B9EGG9 Q14831 Q59G95
PDB IDs		3MQ4 5C5C 7EPC 7EPD
Enriched GO Terms of Interacting Partners?		Cytoskeleton Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Structural Constituent Of Cytoskeleton Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Mitotic Cell Cycle Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling GTP Binding Protein Phosphatase Activator Activity Calyx Of Held Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Microtubule Cytoskeleton Organization Calcineurin-mediated Signaling Presynaptic Cytosol Microtubule Cytoskeleton Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Calcium Ion Transmembrane Transport Response To Calcium Ion Transmembrane Transporter Binding Spindle Microtubule Presynaptic Endocytosis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Substantia Nigra Development Microtubule Calcium Channel Regulator Activity Cytoskeleton Organization Sperm Midpiece Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Positive Regulation Of Sequestering Of Calcium Ion Sarcomere Cell Cycle G2/M Phase Transition Regulation Of Action Potential Negative Regulation Of Voltage-gated Calcium Channel Activity Neural Nucleus Development Regulation Of Synaptic Plasticity
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