TSPYL1 and HAP1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TSPYL1	HAP1
Gene Name		TSPY-like 1	huntingtin-associated protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus	Nucleus Mitochondrion Lysosome Autophagic Vacuole Endoplasmic Reticulum Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Cell Junction Axon
	Molecular Function	Enzyme Binding	Protein Binding Ion Channel Binding Brain-derived Neurotrophic Factor Binding
	Biological Process	Nucleosome Assembly Biological_process	Exocytosis Autophagy Synaptic Transmission Brain Development Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Protein Localization Protein Transport Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Neurogenesis Negative Regulation Of Beta-amyloid Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Nonmotile Primary Cilium Assembly
Pathways
Drugs
Diseases
GWAS			Esophageal cancer (squamous cell) ( 22960999)
Protein-Protein Interactions		2 interactors: APP HAP1	68 interactors: APLP1 ATP5J2 BARD1 BRD7 C7orf25 C8orf33 CBX8 CCDC113 CDC73 CDK5RAP2 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FAM173A FEZ1 GADD45G GIT1 GLTSCR2 GPRASP2 HGS HMOX2 HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A PABPC4 PCM1 PDCD7 PFDN1 PPID PPOX PSMD11 RER1 RIF1 RPS10 RPS25 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZNF20 ZNF24 ZNF33B ZNF691
Entrez ID		7259	9001
HPRD ID		05278	02972
Ensembl ID			ENSG00000173805
Uniprot IDs		Q9H0U9	P54257
PDB IDs
Enriched GO Terms of Interacting Partners?		Axon Cargo Transport Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Regulation Of Receptor Activity Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Synaptic Growth At Neuromuscular Junction Microtubule-based Movement Exocytosis Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Collateral Sprouting In Absence Of Injury Positive Regulation Of Cilium Assembly Regulation Of Mitotic Cell Cycle Response To Oxidative Stress Forebrain Development Posttranscriptional Regulation Of Gene Expression Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Cell Cycle Process Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Secretion By Cell Axon Choice Point Recognition Secretion Hypothalamus Cell Differentiation Neuron Remodeling Negative Regulation Of Beta-amyloid Formation Retrograde Axon Cargo Transport Cellular Homeostasis Regulation Of Neurogenesis Brain Development Microtubule-based Process Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Microtubule-based Movement Head Development Positive Regulation Of Synaptic Transmission, GABAergic Regulation Of Cell Development Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Protein Metabolic Process	Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoplasmic Transport Intracellular Transport Establishment Of Localization In Cell Establishment Of Protein Localization To Organelle RNA Biosynthetic Process Organelle Organization Protein Localization To Organelle Viral Process Protein Targeting Negative Regulation Of Cellular Metabolic Process Cellular Localization Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Process Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Macromolecule Biosynthetic Process Mitochondrial Transport Regulation Of Nitrogen Compound Metabolic Process Intracellular Protein Transport Actin-myosin Filament Sliding Muscle Filament Sliding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Protein Localization Biosynthetic Process Protein Transport Endosomal Transport Cellular Metabolic Process Actin-mediated Cell Contraction Protein Localization Establishment Of Protein Localization Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport MRNA Metabolic Process Chromatin Organization Cell Cycle Regulation Of Cell Cycle Protein Transmembrane Transport Actin Filament-based Movement Organelle Localization Protein Targeting To Mitochondrion Negative Regulation Of Neurogenesis
Tagcloud ?			autism axons cognition elucidated hippocampal huntingtin impairs knockdown morphogenesis mtorc1 neurons partner phenotypes polarity positioning profoundly proteomics pyramidal recapitulate reflected s6 specification supernumerary suppresses tsc tsc1 tsc2 tuberous uncover
Tagcloud (Difference) ?			autism axons cognition elucidated hippocampal huntingtin impairs knockdown morphogenesis mtorc1 neurons partner phenotypes polarity positioning profoundly proteomics pyramidal recapitulate reflected s6 specification supernumerary suppresses tsc tsc1 tsc2 tuberous uncover
Tagcloud (Intersection) ?