C4B and C2

Number of citations: 0 (PubMedID 11341920)
Data Source: BioGRID (pull down)

		C4B	C2
Name		complement C4B (Chido/Rodgers blood group)	complement C2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Axon Dendrite Cell Projection Synapse Extracellular Exosome Blood Microparticle Symbiont Cell Surface	Extracellular Region Classical-complement-pathway C3/C5 Convertase Complex Extracellular Space Cell Surface Extracellular Exosome Symbiont Cell Surface
	Molecular Function	Complement Binding Antigen Binding Endopeptidase Inhibitor Activity Protein Binding Carbohydrate Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Immune System Process Inflammatory Response Complement Activation Complement Activation, Classical Pathway Opsonization Detection Of Molecule Of Bacterial Origin Innate Immune Response Complement Activation, GZMK Pathway Positive Regulation Of Apoptotic Cell Clearance	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Response To Nutrient Opsonization Response To Bacterium Killing Of Cells Of Another Organism Response To Lipopolysaccharide Innate Immune Response Protein Maturation Response To Thyroid Hormone Complement Activation, GZMK Pathway Positive Regulation Of Apoptotic Cell Clearance
Pathways		Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade	Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade
Drugs		Human immunoglobulin G Human immunoglobulin G Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	None
Diseases		None	Systemic lupus erythematosus Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Asthma ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Feeling worry ( 29500382 ) Inflammatory bowel disease ( 28067908 ) Neuromyelitis optica ( 29769526 ) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526 ) Prostate cancer ( 23535732 ) Reticulocyte count ( 32888494 ) Ulcerative colitis ( 28067908 )	A body shape index ( 34021172 ) Advanced age-related macular degeneration ( 26691988 ) Age at first sexual intercourse ( 34211149 ) Age-related macular degeneration ( 20385826 23455636 20385819 21665990 ) Age-related macular degeneration (choroidal neovascularisation) ( 22705344 ) Age-related macular degeneration (geographic atrophy) ( 22705344 ) Asthma ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Circulating myeloperoxidase levels (serum) ( 23620142 ) Clostridioides difficle infection ( 33841421 ) Coffee consumption ( 31046077 ) Coronary artery disease ( 29212778 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Disease progression in age-related macular degeneration ( 29346644 ) Early age-related macular degeneration ( 32843070 ) Endometriosis ( 28881265 ) Estimated glomerular filtration rate ( 31451708 ) Estimated glomerular filtration rate in diabetes ( 31451708 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hepatocellular carcinoma ( 21105107 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Mosquito bite size ( 28199695 ) Platelet aggregation ( 29185836 ) Prostate cancer ( 23535732 ) Sulfasalazine-induced agranulocytosis ( 28762467 ) Systemic lupus erythematosus ( 24871463 ) Ulcerative colitis ( 28067908 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Youthful appearance (self-reported) ( 32339537 )
Interacting Genes		1 interacting genes: C2	14 interacting genes: C3 C4B C5 CREB3 EBP ERGIC3 FAM209A MASP1 MUC1 PSMA4 SEC11C SLC10A1 SLC35H1 STOM
Entrez ID		721	717
HPRD ID		Not available	08939
Ensembl ID		ENSG00000224389	ENSG00000166278
Uniprot IDs		P0C0L4 P0C0L5	A0A0G2JL69 B4DQI1 B4DV48 P06681 Q53HP3 Q5JP69 Q8N6L6
PDB IDs		1HZF 5JPM 5JPN 5JTW 6YSQ 7B2M 7B2P 7B2Q	2I6Q 2I6S 2ODP 2ODQ 3ERB 8ACF 8ACI
GO Terms Enriched among Interactors		Complement Activation, Lectin Pathway Classical-complement-pathway C3/C5 Convertase Complex Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Regulation Of Apoptotic Cell Clearance Positive Regulation Of Apoptotic Cell Clearance Opsonization Symbiont Cell Surface Response To Thyroid Hormone Complement Activation, Classical Pathway Complement Activation Positive Regulation Of Phagocytosis Regulation Of Phagocytosis Serine-type Peptidase Activity Killing Of Cells Of Another Organism Response To Nutrient Serine-type Endopeptidase Activity Positive Regulation Of Endocytosis Cell Killing	Complement Activation, Lectin Pathway Complement Activation Complement Activation, GZMK Pathway Complement Activation, Alternative Pathway Opsonization Symbiont Cell Surface Humoral Immune Response Complement Activation, Classical Pathway Endopeptidase Inhibitor Activity Regulation Of Humoral Immune Response Immune Effector Process Activation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Activation Of Membrane Attack Complex Positive Regulation Of Inflammatory Response To Antigenic Stimulus Extracellular Space Positive Regulation Of Immune System Process Regulation Of Complement Activation Positive Regulation Of Humoral Immune Response Innate Immune Response Receptor Ligand Activity Blood Microparticle Killing Of Cells Of Another Organism Positive Regulation Of Immune Response Positive Regulation Of Acute Inflammatory Response Regulation Of Mononuclear Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Production Defense Response To Symbiont Defense Response To Other Organism Antigen Binding Positive Regulation Of Transport Cell Killing Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Lipid Storage Regulation Of Vascular Endothelial Growth Factor Production C5L2 Anaphylatoxin Chemotactic Receptor Binding Chemokine Activity Regulation Of Acute Inflammatory Response Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Deacetylase Activity Cholesterol-5,6-oxide Hydrolase Activity Regulation Of Leukocyte Migration Extracellular Exosome Regulation Of Immune Response Leukocyte Migration