C4B

Description		complement C4B (Chido/Rodgers blood group)
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Axon Dendrite Cell Projection Synapse Extracellular Exosome Blood Microparticle Symbiont Cell Surface
	Molecular Function	Complement Binding Antigen Binding Endopeptidase Inhibitor Activity Protein Binding Carbohydrate Binding
	Biological Process	Immune System Process Inflammatory Response Complement Activation Complement Activation, Classical Pathway Opsonization Detection Of Molecule Of Bacterial Origin Innate Immune Response Complement Activation, GZMK Pathway Positive Regulation Of Apoptotic Cell Clearance
Pathways		Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade
Drugs		Human immunoglobulin G Human immunoglobulin G Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Feeling worry ( 29500382) Inflammatory bowel disease ( 28067908) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Prostate cancer ( 23535732) Reticulocyte count ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		1 interacting genes: C2
Entrez ID		721
HPRD ID
Ensembl ID		ENSG00000224389
Uniprot IDs		P0C0L4 P0C0L5
PDB IDs		1HZF 5JPM 5JPN 5JTW 6YSQ 7B2M 7B2P 7B2Q
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Classical-complement-pathway C3/C5 Convertase Complex Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Regulation Of Apoptotic Cell Clearance Positive Regulation Of Apoptotic Cell Clearance Opsonization Symbiont Cell Surface Response To Thyroid Hormone Complement Activation, Classical Pathway Complement Activation Positive Regulation Of Phagocytosis Regulation Of Phagocytosis Serine-type Peptidase Activity Killing Of Cells Of Another Organism Response To Nutrient Serine-type Endopeptidase Activity Positive Regulation Of Endocytosis Cell Killing
Tagcloud ?