C4A and C5AR2

Number of citations of the paper that reports this interaction (PMID 11773063)
43

Data Source:
HPRD (in vitro)

		C4A	C5AR2
Gene Name		complement component 4A (Rodgers blood group)	complement component 5a receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Plasma Membrane Basal Plasma Membrane Integral Component Of Membrane Apical Part Of Cell
	Molecular Function	Complement Component C1q Binding Endopeptidase Inhibitor Activity	C5a Anaphylatoxin Receptor Activity Protein Binding
	Biological Process	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance	Chemotaxis Inflammatory Response G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Interleukin-6 Secretion Regulation Of Interleukin-8 Secretion
Pathways		Regulation of Complement cascade Complement cascade Activation of C3 and C5 Initial triggering of complement Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		6 interactors: APC APOA2 C3AR1 C5AR2 CR1 CST3	3 interactors: C3 C4A C5AR1
Entrez ID		720	27202
HPRD ID		00401	17072
Ensembl ID		ENSG00000244731	ENSG00000134830
Uniprot IDs		P0C0L4	Q9P296
PDB IDs		1HZF 4FXG 4FXK
Enriched GO Terms of Interacting Partners?		Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Defense Response Response To Stress Negative Regulation Of Catalytic Activity Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Negative Regulation Of Cytokine Secretion Regulation Of Granulocyte Chemotaxis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Immune System Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Inflammatory Response Regulation Of Cytokine Production Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Cholesterol Transporter Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Protein Secretion Regulation Of Cell Migration Regulation Of Leukocyte Migration Regulation Of Cell Motility Negative Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Immune Response Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Cytokine Secretion Regulation Of Chemotaxis Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Complement Activation, Alternative Pathway Regulation Of Cholesterol Transporter Activity Negative Regulation Of Cholesterol Import Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Protein Localization Negative Regulation Of Secretion By Cell Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Collagen Catabolic Process Regulation Of Cholesterol Import Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Secretion Negative Regulation Of Protein Transport Regulation Of Immune Response Regulation Of Behavior Regulation Of Protein Metabolic Process Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Extracellular Matrix Organization	Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Regulation Of Complement Activation Inflammatory Response Positive Regulation Of Phagocytosis Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Regulation Of Phagocytosis Regulation Of Acute Inflammatory Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Endocytosis Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Complement Component C5a Signaling Pathway Protein Activation Cascade Immune Response Immunoglobulin Mediated Immune Response Regulation Of Immune System Process B Cell Mediated Immunity Regulation Of Endocytosis Defense Response Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Endopeptidase Activity Leukocyte Mediated Immunity Adaptive Immune Response Negative Regulation Of Peptidase Activity Regulation Of Inflammatory Response Positive Regulation Of Activation Of Membrane Attack Complex Cell Proliferation In Hindbrain Complement Receptor Mediated Signaling Pathway Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Vesicle-mediated Transport Immune System Process Regulation Of Endopeptidase Activity Positive Regulation Of Hypersensitivity Regulation Of Protein Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Catalytic Activity Complement Activation, Alternative Pathway Positive Regulation Of Inflammatory Response To Antigenic Stimulus MRNA Transcription From RNA Polymerase II Promoter
Tagcloud ?		alleles antitopoisomerase backgrounds c4aq0 c4b c4bq0 carried complement contribution diffuse dr drb1 electrophoresis genetical genotyping hla immunoblotting immunofixation japanese pc positivity q0 reflected scl scleroderma ssc sscp subgroup typing
Tagcloud (Difference) ?		alleles antitopoisomerase backgrounds c4aq0 c4b c4bq0 carried complement contribution diffuse dr drb1 electrophoresis genetical genotyping hla immunoblotting immunofixation japanese pc positivity q0 reflected scl scleroderma ssc sscp subgroup typing
Tagcloud (Intersection) ?