C4A and C5AR2

Number of citations of the paper that reports this interaction (PubMedID 11773063)
0

Data Source:
HPRD (in vitro)

		C4A	C5AR2
Description		complement C4A (Chido/Rodgers blood group)	complement C5a receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Classical-complement-pathway C3/C5 Convertase Complex Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Axon Dendrite Cell Projection Neuronal Cell Body Synapse Extracellular Exosome Blood Microparticle Symbiont Cell Surface	Plasma Membrane Basal Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	Complement Binding Complement Component C1q Complex Binding Antigen Binding Endopeptidase Inhibitor Activity Protein Binding	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Inflammatory Response Complement Activation Complement Activation, Classical Pathway Opsonization Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation Complement Activation, GZMK Pathway Positive Regulation Of Apoptotic Cell Clearance	Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Negative Regulation Of Neutrophil Chemotaxis
Pathways		Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade	Peptide ligand-binding receptors Regulation of Complement cascade
Drugs		Human immunoglobulin G
Diseases		Systemic lupus erythematosus Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Feeling worry ( 29500382) Inflammatory bowel disease ( 28067908) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908)
Interacting Genes		8 interacting genes: APC APOA2 C3AR1 C5AR2 CR1 CST3 HSP90AA1 MASP2	17 interacting genes: ABCA7 ACO2 ARLN C3 C4A C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234
Entrez ID		720	27202
HPRD ID		00401	17072
Ensembl ID		ENSG00000244731	ENSG00000134830
Uniprot IDs		P0C0L4	Q9P296
PDB IDs		1HZF 5JPM 5JPN 5JTW 6YSQ 7B2M 7B2P 7B2Q
Enriched GO Terms of Interacting Partners?		Complement Receptor Activity Complement Receptor Mediated Signaling Pathway Complement Component C4b Binding Complement Component C5a Receptor Activity Activation Of Immune Response Complement Component C5a Signaling Pathway Positive Regulation Of Immune Response Regulation Of Cytokine Production Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Immune System Process Response To Stress Regulation Of Neutrophil Chemotaxis Complement Activation, Classical Pathway Defense Response Regulation Of Neutrophil Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Granulocyte Chemotaxis Complement Activation Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Complement Component C3a Receptor Activity Complement Component C3b Receptor Activity Immune Complex Clearance By Erythrocytes Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process CTP Binding DATP Binding Regulation Of Protein Catabolic Process Regulation Of Interleukin-8 Production Immune Response-regulating Signaling Pathway Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Plasma Cell Differentiation Negative Regulation Of Blood Vessel Remodeling Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Extracellular Exosome Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cytokine Production Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cholesterol Import	Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Classical-complement-pathway C3/C5 Convertase Complex Amyloid-beta Clearance Regulation Of Endocytosis Positive Regulation Of Phagocytosis Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Positive Regulation Of Phagocytosis, Engulfment Complement Receptor Mediated Signaling Pathway Opsonization Regulation Of Phagocytosis Regulation Of Vesicle-mediated Transport Symbiont Cell Surface Transmembrane Transporter Binding Locomotion Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endocytosis Antigen Binding Complement Activation, Classical Pathway Regulation Of Vascular Endothelial Growth Factor Production C5L2 Anaphylatoxin Chemotactic Receptor Binding Endopeptidase Inhibitor Activity Plasma Membrane Presynaptic Endocytosis Corticospinal Neuron Axon Guidance Oxoglutarate:malate Antiporter Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Complement Activation Positive Regulation Of Activation Of Membrane Attack Complex Basolateral Plasma Membrane Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Positive Regulation Of Voltage-gated Sodium Channel Activity Apolipoprotein A-I Receptor Activity Positive Regulation Of Engulfment Of Apoptotic Cell Regulation Of Engulfment Of Apoptotic Cell Scrib-APC-beta-catenin Complex
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