C4A and C3AR1

Number of citations of the paper that reports this interaction (PMID 9725198)
0

Data Source:
HPRD (in vitro)

		C4A	C3AR1
Gene Name		complement component 4A (Rodgers blood group)	complement component 3a receptor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Complement Component C1q Binding Endopeptidase Inhibitor Activity	Phosphatidylinositol Phospholipase C Activity Complement Component C3a Receptor Activity G-protein Coupled Receptor Activity C3a Anaphylatoxin Receptor Activity
	Biological Process	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Metabolic Process Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Angiogenesis Positive Regulation Of Neutrophil Chemotaxis
Pathways		Regulation of Complement cascade Complement cascade Activation of C3 and C5 Initial triggering of complement Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		6 interactors: APC APOA2 C3AR1 C5AR2 CR1 CST3	3 interactors: C3 C4A SNTA1
Entrez ID		720	719
HPRD ID		00401	05581
Ensembl ID		ENSG00000244731	ENSG00000171860
Uniprot IDs		P0C0L4	A8K2H7 Q16581
PDB IDs		1HZF 4FXG 4FXK
Enriched GO Terms of Interacting Partners?		Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Defense Response Response To Stress Negative Regulation Of Catalytic Activity Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Negative Regulation Of Cytokine Secretion Regulation Of Granulocyte Chemotaxis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Immune System Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Inflammatory Response Regulation Of Cytokine Production Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Cholesterol Transporter Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Protein Secretion Regulation Of Cell Migration Regulation Of Leukocyte Migration Regulation Of Cell Motility Negative Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Immune Response Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Cytokine Secretion Regulation Of Chemotaxis Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Complement Activation, Alternative Pathway Regulation Of Cholesterol Transporter Activity Negative Regulation Of Cholesterol Import Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Protein Localization Negative Regulation Of Secretion By Cell Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Collagen Catabolic Process Regulation Of Cholesterol Import Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Secretion Negative Regulation Of Protein Transport Regulation Of Immune Response Regulation Of Behavior Regulation Of Protein Metabolic Process Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Extracellular Matrix Organization	Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Regulation Of Complement Activation Positive Regulation Of Phagocytosis Regulation Of Humoral Immune Response Regulation Of Phagocytosis Regulation Of Acute Inflammatory Response Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Endocytosis Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Regulation Of Vasoconstriction By Circulating Norepinephrine Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Regulation Of Endocytosis Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Endopeptidase Activity Leukocyte Mediated Immunity Adaptive Immune Response Negative Regulation Of Peptidase Activity Regulation Of Inflammatory Response Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Cellular Metabolic Process Regulation Of Vesicle-mediated Transport Regulation Of Endopeptidase Activity Positive Regulation Of Hypersensitivity Regulation Of Protein Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Inflammatory Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Complement Activation, Alternative Pathway Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Proteolysis Positive Regulation Of Protein Processing Regulation Of Triglyceride Biosynthetic Process
Tagcloud ?		alleles antitopoisomerase backgrounds c4aq0 c4b c4bq0 carried complement contribution diffuse dr drb1 electrophoresis genetical genotyping hla immunoblotting immunofixation japanese pc positivity q0 reflected scl scleroderma ssc sscp subgroup typing	african chabaudi cope demonstration falciparum fcgr3b highlighted hosts implicate implicating interplay lrrc25 malaria mapped mounted noncoding plasmodium polygenic rad21 responders retn sco1 signature slc39a8 slc3a2 tapbp transcriptomes validated west
Tagcloud (Difference) ?		alleles antitopoisomerase backgrounds c4aq0 c4b c4bq0 carried complement contribution diffuse dr drb1 electrophoresis genetical genotyping hla immunoblotting immunofixation japanese pc positivity q0 reflected scl scleroderma ssc sscp subgroup typing	african chabaudi cope demonstration falciparum fcgr3b highlighted hosts implicate implicating interplay lrrc25 malaria mapped mounted noncoding plasmodium polygenic rad21 responders retn sco1 signature slc39a8 slc3a2 tapbp transcriptomes validated west
Tagcloud (Intersection) ?