C4A

Gene Name		complement component 4A (Rodgers blood group)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Complement Component C1q Binding Endopeptidase Inhibitor Activity
	Biological Process	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways		Regulation of Complement cascade Complement cascade Activation of C3 and C5 Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-protein Interactions		6 interactors: APC APOA2 C3AR1 C5AR2 CR1 CST3
Entrez ID		720
HPRD ID		00401
Ensembl ID		ENSG00000244731
Uniprot IDs		P0C0L4
PDB IDs		1HZF 4FXG 4FXK
Enriched GO Terms of Interacting Partners?		Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Defense Response Response To Stress Negative Regulation Of Catalytic Activity Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Negative Regulation Of Cytokine Secretion Regulation Of Granulocyte Chemotaxis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Immune System Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Inflammatory Response Regulation Of Cytokine Production Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Cholesterol Transporter Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Protein Secretion Regulation Of Cell Migration Regulation Of Leukocyte Migration Regulation Of Cell Motility Negative Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Immune Response Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Cytokine Secretion Regulation Of Chemotaxis Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Complement Activation, Alternative Pathway Regulation Of Cholesterol Transporter Activity Negative Regulation Of Cholesterol Import Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Protein Localization Negative Regulation Of Secretion By Cell Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Collagen Catabolic Process Regulation Of Cholesterol Import Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Secretion Negative Regulation Of Protein Transport Regulation Of Immune Response Regulation Of Behavior Regulation Of Protein Metabolic Process Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Extracellular Matrix Organization
Tagcloud ?		alleles antitopoisomerase backgrounds c4aq0 c4b c4bq0 carried complement contribution diffuse dr drb1 electrophoresis genetical genotyping hla immunoblotting immunofixation japanese pc positivity q0 reflected scl scleroderma ssc sscp subgroup typing