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C4A and MASP2
Number of citations of the paper that reports this interaction (PubMedID
36100602
)
67
Data Source:
BioGRID
(enzymatic study)
C4A
MASP2
Description
complement C4A (Chido/Rodgers blood group)
MBL associated serine protease 2
Image
GO Annotations
Cellular Component
Extracellular Region
Classical-complement-pathway C3/C5 Convertase Complex
Extracellular Space
Endoplasmic Reticulum Lumen
Plasma Membrane
Cell Surface
Axon
Dendrite
Cell Projection
Neuronal Cell Body
Synapse
Extracellular Exosome
Blood Microparticle
Symbiont Cell Surface
Extracellular Region
Extracellular Space
Extracellular Exosome
Symbiont Cell Surface
Molecular Function
Complement Binding
Complement Component C1q Complex Binding
Antigen Binding
Endopeptidase Inhibitor Activity
Protein Binding
Complement Component C4b Binding
Serine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Identical Protein Binding
Metal Ion Binding
Calcium-dependent Protein Binding
Biological Process
Complement Activation, Lectin Pathway
Activation Of Membrane Attack Complex
Immune System Process
Inflammatory Response
Complement Activation
Complement Activation, Classical Pathway
Opsonization
Killing Of Cells Of Another Organism
Innate Immune Response
Protein Maturation
Complement Activation, GZMK Pathway
Positive Regulation Of Apoptotic Cell Clearance
Complement Activation, Lectin Pathway
Activation Of Membrane Attack Complex
Immune System Process
Proteolysis
Complement Activation
Complement Activation, Classical Pathway
Opsonization
Zymogen Activation
Killing Of Cells Of Another Organism
Innate Immune Response
Protein Maturation
Pathways
Initial triggering of complement
Activation of C3 and C5
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Regulation of Complement cascade
Drugs
Human immunoglobulin G
beta-Hydroxyasparagine
Narsoplimab
Diseases
Systemic lupus erythematosus
Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency
GWAS
Asthma (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Feeling worry (
29500382
)
Inflammatory bowel disease (
28067908
)
Neurociticism (
29500382
)
Neuromyelitis optica (
29769526
)
Neuromyelitis optica (AQP4-IgG-positive) (
29769526
)
Prostate cancer (
23535732
)
Ulcerative colitis (
28067908
)
Appendicular lean mass (
33097823
)
Beard thickness (
26926045
)
Body mass index (
29273807
)
Eosinophil percentage of white cells (
32888494
)
Male-pattern baldness (
28196072
)
Interacting Genes
8 interacting genes:
APC
APOA2
C3AR1
C5AR2
CR1
CST3
HSP90AA1
MASP2
4 interacting genes:
C4A
FCN2
MBL2
SERPING1
Entrez ID
720
10747
HPRD ID
00401
05484
Ensembl ID
ENSG00000244731
ENSG00000009724
Uniprot IDs
P0C0L4
A0A8V8TPN9
A0A8V8TQY3
O00187
PDB IDs
1HZF
5JPM
5JPN
5JTW
6YSQ
7B2M
7B2P
7B2Q
1Q3X
1SZB
1ZJK
3TVJ
5JPM
Enriched GO Terms of Interacting Partners
?
Complement Receptor Activity
Complement Receptor Mediated Signaling Pathway
Complement Component C4b Binding
Complement Component C5a Receptor Activity
Activation Of Immune Response
Complement Component C5a Signaling Pathway
Positive Regulation Of Immune Response
Regulation Of Cytokine Production
Regulation Of Immune System Process
Regulation Of Immune Response
Regulation Of Multicellular Organismal Process
Positive Regulation Of Immune System Process
Immune System Process
Response To Stress
Regulation Of Neutrophil Chemotaxis
Complement Activation, Classical Pathway
Defense Response
Regulation Of Neutrophil Migration
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Granulocyte Chemotaxis
Complement Activation
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Cytokine Production
Immune Response-activating Signaling Pathway
Complement Component C3a Receptor Activity
Complement Component C3b Receptor Activity
Immune Complex Clearance By Erythrocytes
Complement Component C4b Receptor Activity
Negative Regulation Of Serine-type Endopeptidase Activity
Negative Regulation Of Collagen Catabolic Process
Negative Regulation Of Elastin Catabolic Process
CTP Binding
DATP Binding
Regulation Of Protein Catabolic Process
Regulation Of Interleukin-8 Production
Immune Response-regulating Signaling Pathway
Positive Regulation Of Activation Of Membrane Attack Complex
Negative Regulation Of Plasma Cell Differentiation
Negative Regulation Of Blood Vessel Remodeling
Neurofibrillary Tangle Assembly
UTP Binding
Sulfonylurea Receptor Binding
Extracellular Exosome
Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly
Positive Regulation Of Cytokine Production
Peptidyl-methionine Modification
High-density Lipoprotein Particle Receptor Binding
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Cholesterol Import
Complement Activation, Lectin Pathway
Activation Of Membrane Attack Complex
Opsonization
Symbiont Cell Surface
Complement Activation
Regulation Of Immune Response
Positive Regulation Of Phagocytosis
Regulation Of Phagocytosis
Positive Regulation Of Opsonization
Blood Microparticle
Killing Of Cells Of Another Organism
Regulation Of Opsonization
Defense Response To Gram-positive Bacterium
Serine-type Endopeptidase Complex
Regulation Of Immune System Process
Positive Regulation Of Endocytosis
Innate Immune Response
Cell Killing
Defense Response To Symbiont
Defense Response To Other Organism
Humoral Immune Response
Antigen Binding
Positive Regulation Of Immune Effector Process
Complement Activation, Classical Pathway
Zymogen Activation
Pattern Recognition Receptor Activity
Defense Response To Bacterium
Protein Maturation
Positive Regulation Of Immune System Process
Regulation Of Endocytosis
Response To Other Organism
External Side Of Plasma Membrane
Cell Surface Pattern Recognition Receptor Signaling Pathway
Immune Response
Immune Effector Process
Response To Bacterium
Activation Of Immune Response
Response To External Biotic Stimulus
Regulation Of Innate Immune Response
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Defense Response
Collagen Trimer
Calcium-dependent Protein Binding
Extracellular Space
Defense Response To Gram-negative Bacterium
Mannan Binding
Regulation Of Vesicle-mediated Transport
Negative Regulation Of Complement Activation, Lectin Pathway
Positive Regulation Of Immune Response
Lipoteichoic Acid Immune Receptor Activity
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Tagcloud (Intersection)
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