TPM4 and TPM1

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (two hybrid, biochemical)

		TPM4	TPM1
Gene Name		tropomyosin 4	tropomyosin 1 (alpha)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Podosome Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Focal Adhesion Membrane Cortical Cytoskeleton Filamentous Actin Extracellular Vesicular Exosome	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Sarcomere Filamentous Actin Bleb Ruffle Membrane
	Molecular Function	Actin Binding Calcium Ion Binding Structural Constituent Of Muscle	Actin Binding Structural Constituent Of Cytoskeleton Cytoskeletal Protein Binding Structural Constituent Of Muscle
	Biological Process	Osteoblast Differentiation Movement Of Cell Or Subcellular Component Muscle Contraction Muscle Filament Sliding	In Utero Embryonic Development Positive Regulation Of Heart Rate By Epinephrine Movement Of Cell Or Subcellular Component Muscle Contraction Regulation Of Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Positive Regulation Of ATPase Activity Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction Smooth Muscle Contraction	Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419 22423221) Platelet counts ( 22139419)	Mean platelet volume ( 19820697) Orofacial clefts ( 22863734) Platelet counts ( 22139419)
Protein-Protein Interactions		5 interactors: LNX1 PACSIN1 TCERG1 TPM1 TRIP6	18 interactors: ACTB C1orf216 CAGE1 EGFR EPB41 GOLGA2 JUN KXD1 MAD1L1 PKD2 S100A2 SYCE1 TFPT TMOD2 TNNT1 TNNT2 TPM2 TPM4
Entrez ID		7171	7168
HPRD ID		11734	01839
Ensembl ID		ENSG00000167460	ENSG00000140416
Uniprot IDs		P67936	B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H7BYY1 O15513 P09493 Q6ZN40
PDB IDs
Enriched GO Terms of Interacting Partners?			Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Actin Filament-based Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Movement Of Cell Or Subcellular Component Response To Calcium Ion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Liver Development Immune Response-regulating Signaling Pathway Response To Inorganic Substance Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of ATPase Activity Negative Regulation Of Mitotic Cell Cycle Response To Mechanical Stimulus Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Heart Morphogenesis Organelle Organization Regulation Of Binding Positive Regulation Of Smooth Muscle Cell Proliferation Learning Or Memory Regulation Of Nitric Oxide Biosynthetic Process Alkanesulfonate Metabolic Process Metanephric Cortex Development Metanephric Cortical Collecting Duct Development Regulation Of Metaphase Plate Congression Cellular Response To Potassium Ion Starvation Fc Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Proliferation Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Epithelial Cell Proliferation Cognition Positive Regulation Of DNA Replication Mitotic Cell Cycle Response To Metal Ion Myofibril Assembly Protein Kinase D Signaling Leading Edge Cell Differentiation Metanephric Smooth Muscle Tissue Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Detection Of Nodal Flow Astrocyte Activation Renal Artery Morphogenesis
Tagcloud ?		12q alk backgroundthe ccnd3 conclusionsour ews fli1 foxo1 fusion fusions harbor inactivating kcnmb4 lrp1 methodstranscriptome opportunities osteosarcoma osteosarcomas pax3 resultsnine sanger saos sarcomas snrnp25 ssx1 ssx2 syt tpm3 transcriptome	abp1 abp1p act1 actin cap1 cap2 capping cerevisiae cytoskeleton deleterious draw extreme fimbrin inviability lacking lethal lethality null organization phenotypes physiology redundancy redundant sac6 saccharomyces surprising synthetic tropomyosin viable
Tagcloud (Difference) ?		12q alk backgroundthe ccnd3 conclusionsour ews fli1 foxo1 fusion fusions harbor inactivating kcnmb4 lrp1 methodstranscriptome opportunities osteosarcoma osteosarcomas pax3 resultsnine sanger saos sarcomas snrnp25 ssx1 ssx2 syt tpm3 transcriptome	abp1 abp1p act1 actin cap1 cap2 capping cerevisiae cytoskeleton deleterious draw extreme fimbrin inviability lacking lethal lethality null organization phenotypes physiology redundancy redundant sac6 saccharomyces surprising synthetic tropomyosin viable
Tagcloud (Intersection) ?