TPD52L2 and ADORA2B

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		TPD52L2	ADORA2B
Name		TPD52 like 2	adenosine A2b receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding Protein Homodimerization Activity	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Carbohydrate Metabolic Process Regulation Of Cell Population Proliferation	G Protein-coupled Adenosine Receptor Signaling Pathway Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Vasodilation Mast Cell Degranulation Positive Regulation Of Mast Cell Degranulation Relaxation Of Vascular Associated Smooth Muscle Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		None	Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production
Drugs		Phenethyl Isothiocyanate	Caffeine Theophylline Adenosine Enprofylline Defibrotide CVT-6883
GWAS		Prostate cancer ( 23535732 )	HDL cholesterol levels in HIV infection ( 33109212 ) Immune reponse to smallpox (secreted IL-12p40) ( 22610502 )
Interacting Genes		10 interacting genes: ABHD5 ADORA2B APP CDC42 COQ8A MAL2 SH3GLB1 TPD52 TPD52L1 TPD52L3	7 interacting genes: ADA DCC EZR NHERF2 NTN1 TPD52L2 ZNF267
Entrez ID		7165	136
HPRD ID		11947	15971
Ensembl ID		ENSG00000101150	ENSG00000170425
Uniprot IDs		A0A087WYR3 A0A087WZ51 O43399 Q68E05 Q6FGS1	P29275
PDB IDs		Not available	7XY6 7XY7 8HDO 8HDP
GO Terms Enriched among Interactors		Lysophosphatidic Acid Acyltransferase Activity Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Homodimerization Activity Phosphatidic Acid Metabolic Process Phosphatidic Acid Biosynthetic Process Protein Localization To Vacuolar Membrane Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Chemokine Production Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Cytokinesis GBD Domain Binding Storage Vacuole Negative Regulation Of Triglyceride Storage Lipase Activator Activity Positive Regulation Of Membrane Tubulation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Chronic Inflammatory Response G Protein-coupled Adenosine Receptor Activity Relaxation Of Vascular Associated Smooth Muscle Regulation Of Vesicle-mediated Transport Regulation Of Interleukin-6 Production Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of JNK Cascade Axon Midline Choice Point Recognition Positive Regulation Of MAPK Cascade	Anterior/posterior Axon Guidance Positive Regulation Of Germinal Center Formation Response To Purine-containing Compound Negative Regulation Of Mucus Secretion Negative Regulation Of Mature B Cell Apoptotic Process Regulation Of T Cell Receptor Signaling Pathway Inosine Biosynthetic Process DATP Metabolic Process Deoxyadenosine Catabolic Process Purine Deoxyribonucleoside Triphosphate Catabolic Process Penile Erection Negative Regulation Of Multicellular Organismal Process Hypoxanthine Metabolic Process Regulation Of Anatomical Structure Morphogenesis Cytoplasmic Vesicle Lumen Hypoxanthine Salvage Mature B Cell Apoptotic Process Cell Adhesion Negative Regulation Of Adenosine Receptor Signaling Pathway Adenosine Catabolic Process 2'-deoxyadenosine Deaminase Activity DATP Catabolic Process DAMP Catabolic Process Xanthine Biosynthetic Process Negative Regulation Of Penile Erection Hypoxanthine Biosynthetic Process Cell-cell Adhesion Regulation Of Developmental Growth Regulation Of Growth Negative Regulation Of Nervous System Development Regulation Of Axonogenesis Dorsal/ventral Axon Guidance Negative Regulation Of Axonogenesis Negative Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Neuron Migration Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Neuron Projection Development Intestinal Hexose Absorption Terminal Web Assembly Protein Localization To Cell Cortex Intestinal D-glucose Absorption Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Cdc42 Protein Signal Transduction Axonogenesis Purine Deoxyribonucleoside Metabolic Process GMP Salvage Purine Ribonucleoside Catabolic Process Deoxyribonucleoside Triphosphate Catabolic Process