GINS1

Description		GINS complex subunit 1
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GO Annotations	Cellular Component	GINS Complex Nucleus Nucleoplasm Chromosome Cytoplasm CMG Complex
	Molecular Function	Protein Binding
	Biological Process	Inner Cell Mass Cell Proliferation DNA Replication DNA Strand Elongation Involved In Mitotic DNA Replication
Pathways		Unwinding of DNA Unwinding of DNA
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Liver enzyme levels (alkaline phosphatase) ( 22001757) Platelet count ( 32888494) Telomere length ( 30185882)
Interacting Genes		2 interacting genes: TOP2A TOPBP1
Entrez ID		9837
HPRD ID		11067
Ensembl ID		ENSG00000101003
Uniprot IDs		A0A8Q3WLJ3 A0A8Q3WLK7 A0A8Q3WLL7 Q14691
PDB IDs		2E9X 2EHO 2Q9Q 6XTX 6XTY 7PFO 7PLO 8B9D 8OK2
Enriched GO Terms of Interacting Partners?		Male Germ Cell Nucleus Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex Broken Chromosome Clustering DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Chromosome Organization BRCA1-B Complex Apoptotic Chromosome Condensation DNA Topoisomerase Activity DNA Topological Change Embryonic Cleavage Double-strand Break Repair Via Alternative Nonhomologous End Joining Phosphorylation-dependent Protein Binding Mitotic DNA Replication Checkpoint Signaling Double-strand Break Repair Via Classical Nonhomologous End Joining Resolution Of Meiotic Recombination Intermediates DNA Metabolic Process Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate DNA Damage Response DNA Binding, Bending DNA Conformation Change Female Meiotic Nuclear Division DNA Replication Checkpoint Signaling Chromatin-protein Adaptor Activity Chromatin Organization Protein Localization To Site Of Double-strand Break DNA Replication Initiation Nuclear Chromosome ATP-dependent Activity, Acting On DNA Positive Regulation Of Viral Genome Replication Condensed Chromosome Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Condensation Homologous Recombination Sister Chromatid Segregation Site Of DNA Damage Protein Kinase C Binding Condensed Nuclear Chromosome Nuclear Chromosome Segregation Mitotic G2/M Transition Checkpoint Double-strand Break Repair Via Nonhomologous End Joining Meiosis I Cell Cycle Process Cellular Response To Stress Positive Regulation Of Viral Process Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Damage Checkpoint Signaling Protein Serine/threonine Kinase Activator Activity Meiotic Nuclear Division
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