CLIP4 and SIX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLIP4	SIX2
Description		CAP-Gly domain containing linker protein family member 4	SIX homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cell Cortex Microtubule Plus-end	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Protein Binding Microtubule Plus-end Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cytoplasmic Microtubule Organization	Metanephros Development Kidney Development Chondrocyte Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Mesodermal Cell Fate Specification Cell Population Proliferation Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Cell Migration Regulation Of Ossification Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Regulation Of Chondrocyte Differentiation Middle Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Nephron Development Nephron Morphogenesis Mesenchymal Stem Cell Maintenance Involved In Nephron Morphogenesis Condensed Mesenchymal Cell Proliferation Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Mesenchymal Stem Cell Proliferation Positive Regulation Of Chondrocyte Proliferation
Pathways			Formation of the ureteric bud
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Blood sugar levels ( 29403010) Clozapine-induced myocarditis in schizophrenia ( 32066683) Fasting blood glucose ( 29621232 33842983) Fasting plasma glucose ( 25187374) Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Lung cancer ( 28604730) Metabolite levels ( 21909109) Refractive error ( 32231278) Retinal arteriole-to-venule ratio ( 31597446)
Interacting Genes		37 interacting genes: APP CDK5RAP2 CLIP1 CMYA5 DCAF6 DES DST DYNC2LI1 GLP1R HSF2BP JAKMIP2 KIF1B KIFC3 LZTS2 MAGEA12 MAP7 MAP7D1 MEOX2 MYBPC1 MYH3 PDE4DIP PEG10 RPS13 RPS27L RUNX1 SIX2 SON TACC3 TAF1 TNNT1 TNNT3 TPM1 TRIM32 TRIP13 TTN TULP3 ZNF114	7 interacting genes: APP CDKN2A CLIP4 EYA1 EYA3 TLE1 TLE5
Entrez ID		79745	10736
HPRD ID		08634	05408
Ensembl ID		ENSG00000115295	ENSG00000170577
Uniprot IDs		A0A8I5KXU9 A0A8I5QKP4 A0A8I5QKV0 A8K6D0 B7Z936 G3XAK3 Q8N3C7	Q8TBA2 Q9NPC8
PDB IDs		2Z0W
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Sarcomere Organization Organelle Organization Microtubule-based Process Microtubule Cytoskeleton Organization Actomyosin Structure Organization Microtubule Skeletal Muscle Contraction Striated Muscle Contraction Microtubule Binding Muscle Filament Sliding Muscle Contraction Actin-myosin Filament Sliding Centrosome Actin Cytoskeleton Organization Cytoskeleton Microtubule Plus-end Microtubule Cytoskeleton Muscle System Process M Band Actin Filament-based Process Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Microtubule Polymerization Actin-mediated Cell Contraction Female Meiosis I Structural Constituent Of Muscle Troponin Complex Myofibril Male Meiotic Nuclear Division Regulation Of Supramolecular Fiber Organization Actin Filament-based Movement Contractile Muscle Fiber Tropomyosin Binding Regulation Of Microtubule Polymerization Cytoskeletal Protein Binding Regulation Of Microtubule Cytoskeleton Organization Transport Along Microtubule Meiotic Nuclear Division Female Meiotic Nuclear Division Axo-dendritic Transport Positive Regulation Of Cytoskeleton Organization Supramolecular Fiber Organization Retrograde Axonal Transport Microtubule Plus-end Binding Positive Regulation Of Protein Polymerization Cytoskeleton-dependent Intracellular Transport Myosin Filament Nuclear Division Regulation Of Cytoskeleton Organization Amyloid-beta Complex	Histone H2AXY142 Phosphatase Activity Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Stress Regulation Of Anoikis Amyloid Fibril Formation Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Signal Transduction Protein Sumoylation Regulation Of Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Signaling Pathway Ligase Inhibitor Activity Otic Vesicle Morphogenesis Response To Interleukin-1 Response To Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Protein Tyrosine Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Apoptotic Process Nucleus Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization
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