PKD2L1 and TNNI2

Number of citations: 0 (PubMedID 12809519)
Data Source: HPRD (in vivo)

		PKD2L1	TNNI2
Name		polycystin 2 like 1, transient receptor potential cation channel	troponin I2, fast skeletal type
Structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cilium Cell Surface Actin Cytoskeleton Membrane Cytoplasmic Vesicle Cation Channel Complex Calcium Channel Complex Cell Projection Receptor Complex Ciliary Membrane Non-motile Cilium	Nucleus Cytosol Troponin Complex
	Molecular Function	Calcium-activated Cation Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Monoatomic Cation Transmembrane Transporter Activity Calcium-activated Potassium Channel Activity Sour Taste Receptor Activity Identical Protein Binding Actinin Binding Transmembrane Transporter Binding Metal Ion Binding Metal Ion Transmembrane Transporter Activity Muscle Alpha-actinin Binding Alpha-actinin Binding PH-gated Monoatomic Ion Channel Activity Osmolarity-sensing Monoatomic Cation Channel Activity	Actin Binding Protein Binding Troponin T Binding
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Smoothened Signaling Pathway Response To Water Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Protein Tetramerization Protein Homotetramerization Calcium Ion Transmembrane Transport Cellular Response To PH Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport	Skeletal Muscle Contraction Positive Regulation Of DNA-templated Transcription Cardiac Muscle Contraction
Pathways		None	Striated Muscle Contraction
Diseases		None	Distal arthrogryposis (DA)
GWAS		A body shape index ( 34021172 ) Coronary artery disease ( 33020668 29212778 ) Diastolic blood pressure ( 30224653 ) Fatty acid desaturase activity (adipose tissue) ( 30453627 ) Heel bone mineral density ( 28869591 30598549 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lymphocyte count ( 32888494 ) Macular thickness ( 30535121 ) Mean platelet volume ( 27863252 32888494 ) Obesity-related traits ( 23251661 ) Palmitic acid (16:0) levels ( 23362303 ) Palmitoleic acid (16:1n-7) levels ( 23362303 28298293 ) Phospholipid levels (plasma) ( 22359512 ) Red cell distribution width ( 32888494 ) Refractive error ( 32231278 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 ) Serum alkaline phosphatase levels ( 33547301 ) Serum metabolite levels ( 24625756 33031748 ) Serum metabolite levels (CMS) ( 31636271 ) Serum metabolite ratios in chronic kidney disease ( 29545352 ) Squamous cell lung carcinoma ( 28604730 ) Vaccenic acid (18:1n-7) levels ( 28298293 )	Celiac disease ( 23936387 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Inflammatory bowel disease ( 23128233 ) Logical memory (delayed recall) in mild cognitive impairment ( 29274321 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 )
Interacting Genes		4 interacting genes: CLDN19 TNNI1 TNNI2 TNNI3	21 interacting genes: ACTB AIRIM CALM1 CTNNA3 DCAF11 DRC8 ESRRA ESRRG HNF4G MNS1 NME7 PKD2L1 PSMC5 RORB TNNC1 TNNC2 TNNT1 TNNT3 TRIM55 TRIM63 UPF2
Entrez ID		9033	7136
HPRD ID		16063	01843
Ensembl ID		ENSG00000107593	ENSG00000130598
Uniprot IDs		Q1L4F0 Q9P0L9	P48788
PDB IDs		3TE3 4GIF 6DU8	2MKP 7KAA
GO Terms Enriched among Interactors		Troponin Complex Skeletal Muscle Contraction Cardiac Muscle Contraction Troponin T Binding Striated Muscle Contraction Muscle Contraction Muscle System Process Actin Binding Ventricular Cardiac Muscle Tissue Morphogenesis System Process Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Regulation Of Striated Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Mesaxon Regulation Of Muscle Contraction Cardiac Troponin Complex Troponin C Binding Regulation Of Transepithelial Transport Regulation Of Muscle System Process Transition Between Fast And Slow Fiber Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Myofibril Apical Junction Assembly Paracellular Tight Junction Channel Activity Retinal Pigment Epithelium Development Paracellular Transport Paranodal Junction Regulation Of Skeletal Muscle Adaptation Schmidt-Lanterman Incisure Action Potential Propagation Neuronal Action Potential Propagation Negative Regulation Of ATP-dependent Activity Tissue Morphogenesis Actin Filament-based Process Contractile Muscle Fiber Calcium Channel Inhibitor Activity Muscle Filament Sliding Actin-myosin Filament Sliding Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Heart Contraction Regulation Of System Process Apical Junction Complex Heart Process Regulation Of ATP-dependent Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell-cell Adhesion Mediator Activity Tight Junction Actin-mediated Cell Contraction Renal Absorption	Troponin Complex Regulation Of Muscle System Process Regulation Of Muscle Contraction Skeletal Muscle Contraction Regulation Of System Process Nuclear Receptor Activity Striated Muscle Contraction Muscle Contraction Troponin I Binding Troponin T Binding Muscle System Process Transition Between Fast And Slow Fiber System Process Estrogen Response Element Binding Regulation Of Skeletal Muscle Adaptation Titin Binding Contractile Muscle Fiber Tropomyosin Binding Calcium-dependent Protein Binding Motile Cilium Intracellular Receptor Signaling Pathway Calyx Of Held Regulation Of Striated Muscle Contraction Nuclear Steroid Receptor Activity Axonemal A Tubule Inner Sheath Calcium Channel Complex Regulation Of Cardiac Muscle Cell Action Potential Steroid Binding Respiratory System Process Cilium Axonemal Microtubule Calcium Ion Binding Eye Photoreceptor Cell Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Photoreceptor Cell Development Tyrosine 3-monooxygenase Activity Dopamine Biosynthetic Process From Tyrosine Regulation Of Muscle Filament Sliding Speed Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Positive Regulation Of Calcium-dependent ATPase Activity Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Sour Taste Receptor Activity Substantia Nigra Development Actin Filament-based Process Cytosol Regulation Of Multicellular Organismal Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Heart Contraction