PKD2L1 and TNNI2

Number of citations of the paper that reports this interaction (PMID 12809519)
4

Data Source:
HPRD (in vivo)

		PKD2L1	TNNI2
Gene Name		polycystic kidney disease 2-like 1	troponin I type 2 (skeletal, fast)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Nonmotile Primary Cilium Calcium Channel Complex Intracellular Membrane-bounded Organelle Receptor Complex Ciliary Membrane	Nucleus Cytosol Troponin Complex
	Molecular Function	Calcium Activated Cation Channel Activity Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cation Transmembrane Transporter Activity Calcium-activated Potassium Channel Activity Sour Taste Receptor Activity Identical Protein Binding Muscle Alpha-actinin Binding Alpha-actinin Binding	Actin Binding Protein Binding Troponin T Binding
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Cation Transport Smoothened Signaling Pathway Sodium Ion Transmembrane Transport Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Protein Homotrimerization Calcium Ion Transmembrane Transport Cellular Response To Acidic PH Potassium Ion Transmembrane Transport	Skeletal Muscle Contraction Regulation Of Muscle Contraction Muscle Filament Sliding Positive Regulation Of Transcription, DNA-templated
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Palmitic acid (16:0) plasma levels ( 23362303) Palmitoleic acid (16:1n-7) plasma levels ( 23362303) Phospholipid levels (plasma) ( 22359512)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		3 interactors: TNNI1 TNNI2 TNNI3	13 interactors: ACTB CALM1 ESRRA HNF4G PKD2L1 RORB TNNC1 TNNC2 TNNT1 TNNT3 TRIM55 TRIM63 UPF2
Entrez ID		9033	7136
HPRD ID		16063	01843
Ensembl ID		ENSG00000107593	ENSG00000130598
Uniprot IDs		Q1L4F0 Q9P0L9	P48788
PDB IDs		3TE3 4GIF
Enriched GO Terms of Interacting Partners?		Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Regulation Of Muscle Contraction Muscle Contraction Muscle System Process Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Actin Filament-based Process Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Striated Muscle Contraction Cardiac Ventricle Development Cardiac Chamber Development Cardiac Muscle Tissue Development Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Movement Of Cell Or Subcellular Component Heart Morphogenesis Muscle Organ Development Striated Muscle Tissue Development Muscle Tissue Development Negative Regulation Of ATPase Activity Muscle Structure Development Heart Development Tissue Morphogenesis Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Skeletal Muscle Contraction Cardiovascular System Development Regulation Of ATPase Activity Organ Morphogenesis Musculoskeletal Movement Cardiac Muscle Contraction Regulation Of Smooth Muscle Contraction Heart Contraction Regulation Of Striated Muscle Contraction Regulation Of Systemic Arterial Blood Pressure Vasculogenesis Tissue Development Regulation Of Blood Pressure	Muscle Contraction Skeletal Muscle Contraction Actin-myosin Filament Sliding Muscle Filament Sliding Muscle System Process Musculoskeletal Movement Actin-mediated Cell Contraction Regulation Of Muscle Contraction Actin Filament-based Movement Striated Muscle Contraction Cellular Response To Steroid Hormone Stimulus Response To Steroid Hormone Steroid Hormone Mediated Signaling Pathway Cellular Response To Organic Cyclic Compound Hormone-mediated Signaling Pathway Response To Lipid Cellular Response To Lipid Response To Organic Cyclic Compound Response To Hormone Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Hormone Stimulus Regulation Of ATPase Activity DNA-templated Transcription, Initiation Actin Filament-based Process Neural Nucleus Development Organ Development Regulation Of Muscle Filament Sliding Speed Movement Of Cell Or Subcellular Component Regulation Of Striated Muscle Contraction Midbrain Development Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Muscle Filament Sliding Diaphragm Contraction Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Osteoblast Differentiation Cellular Response To Organic Substance Signal Transduction Amacrine Cell Differentiation Regulation Of High Voltage-gated Calcium Channel Activity Sensory Perception Of Sour Taste Involuntary Skeletal Muscle Contraction System Development Skeletal Muscle Atrophy Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Response To Glucocorticoid
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