FPR1

Description		formyl peptide receptor 1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Secretory Granule Membrane Azurophil Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	G Protein-coupled Receptor Binding Complement Receptor Activity G Protein-coupled Receptor Activity N-formyl Peptide Receptor Activity Scavenger Receptor Binding Protein Binding RAGE Receptor Binding
	Biological Process	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nitric Oxide Mediated Signal Transduction Signaling
Pathways		G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Interleukin-10 signaling Neutrophil degranulation
Drugs		Nedocromil
Diseases
GWAS		Alopecia areata ( 25608926) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Tourette syndrome ( 30818990)
Novel Interacting Genes		1 novel interacting genes: KIR3DL1
Interacting Genes		5 interacting genes: ACTG1 ANXA1 GNAI2 GRK2 SAA1
Entrez ID		2357
HPRD ID		00646
Ensembl ID		ENSG00000171051
Uniprot IDs		P21462
PDB IDs		7EUO 7T6T 7VFX 7WVU
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Binding G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Secretion Regulation Of Secretion By Cell Regulation Of Transport Negative Regulation Of Exocytosis Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Wound Healing Granulocyte Chemotaxis Basal Body Patch Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Actin Filament Granulocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Vesicle-mediated Transport Edg-2 Lysophosphatidic Acid Receptor Binding Regulation Of Interleukin-1 Production Mononuclear Cell Migration HLA-B Specific Inhibitory MHC Class I Receptor Activity Positive Regulation Of Locomotion Myeloid Leukocyte Migration Regulation Of Wound Healing Leukocyte Chemotaxis Negative Regulation Of Secretion By Cell Regulation Of Transepithelial Transport Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Myoblast Migration Involved In Skeletal Muscle Regeneration Positive Regulation Of Neutrophil Apoptotic Process Protein Localization To Bicellular Tight Junction Regulation Of Cell Adhesion Regulation Of Response To Wounding Dense Body Morphogenesis Of A Polarized Epithelium Cytoplasmic Side Of Mitochondrial Outer Membrane G Protein-coupled Receptor Signaling Pathway Regulation Of The Force Of Heart Contraction By Chemical Signal Alpha-2A Adrenergic Receptor Binding Desensitization Of G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Apoptotic Process Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Secretion Regulation Of Exocytosis Cell Chemotaxis Neutrophil Clearance
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