TLE4 and NUP62

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TLE4	NUP62
Description		TLE family member 4, transcriptional corepressor	nucleoporin 62
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex	Spindle Pole Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Centrosome Cytoskeleton Nuclear Membrane Nuclear Pore Central Transport Channel Mitotic Spindle Flemming Body Ribonucleoprotein Complex
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding DNA-binding Transcription Factor Binding	Chromatin Binding Protein Binding Phospholipid Binding Structural Constituent Of Nuclear Pore Signaling Receptor Complex Adaptor Activity Hsp70 Protein Binding SH2 Domain Binding Ubiquitin Binding PTB Domain Binding Hsp90 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Leukemia Inhibitory Factor	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Mitotic Metaphase Chromosome Alignment Centrosome Cycle Mitotic Centrosome Separation Cell Surface Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Protein Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Regulation Of Ras Protein Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Positive Regulation Of Centriole Replication MRNA Transport Regulation Of Mitotic Spindle Organization Cellular Senescence Centriole Assembly Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Protein Localization To Centrosome
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Asthma (childhood onset) ( 19714205) Bipolar disorder ( 34099189) Bipolar disorder x sex interaction ( 34099189) Chronotype ( 30696823) Daytime nap ( 33568662) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Fasting insulin ( 34059833) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Motion sickness ( 25628336) Neutrophil percentage of white cells ( 32888494) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Platelet count ( 32888494) Plateletcrit ( 32888494) Severe insulin-resistant type 2 diabetes ( 34737425) Type 2 diabetes ( 30718926 32499647 30297969 28869590 26818947 24509480 22885922)
Interacting Genes		11 interacting genes: BRCA1 CRYAA CUX1 LIG4 MSX1 NUP62 OTX1 OTX2 PAX5 POU2F1 SRPK2	88 interacting genes: ABI2 ADAM15 AGR3 ARFIP2 ATF7IP2 ATXN7 BFSP1 BLOC1S6 C14orf119 C1orf216 CAVIN3 CCDC121 CCDC146 CCDC150 CCHCR1 CENPU CEP57L1 CLIC1 CRCT1 DDX3X DGCR6 DPPA3 DRC12 DTNB DYNLT1 FABP3 GOPC GORASP2 GTF2E2 HAUS1 HGS HSF2 HSF4 IDH1 IFT20 IFT25 IK IKBIP IPO5 ISCU KANSL1 KIFC3 KLHL32 KPNA1 KPNA2 KPNB1 KRT1 KRT20 KRT3 KRT6A KRT6B KRT75 LMO2 LNX1 MUC1 MXD3 MYO15B NUP153 NUP54 NUP58 NUP98 NUTF2 NXF1 NXF2 OGT OIP5 OTUD6A PBX2 PELI2 PIN1 PTMA RANBP2 SMARCA2 SMARCE1 SNAPC5 SP1 SSC5D SUOX THAP1 TLE4 TRAF3 TRIML2 TXLNA TXN USHBP1 WASHC3 XPO1 XPO6
Entrez ID		7091	23636
HPRD ID		05502	05782
Ensembl ID		ENSG00000106829	ENSG00000213024
Uniprot IDs		A0A994J7T6 Q04727	P37198
PDB IDs			5IJN 5IJO 7PER 7R5J 7R5K
Enriched GO Terms of Interacting Partners?		Chromatin Midbrain Development DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Forebrain Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Centriole Replication Embryonic Morphogenesis Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Sensory Organ Development Regulation Of Metabolic Process Condensed Chromosome Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Primary Metabolic Process Centrosome Cycle Regulation Of Centrosome Duplication Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Centrosome Cycle Establishment Of Integrated Proviral Latency Negative Regulation Of Odontoblast Differentiation DNA-binding Transcription Factor Activity Diencephalon Morphogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Developmental Process P53 Binding	Nuclear Transport Nucleocytoplasmic Transport Nuclear Localization Sequence Binding Nuclear Pore NLS-bearing Protein Import Into Nucleus RNA Transport Protein Import Into Nucleus Import Into Nucleus Nuclear Export MRNA Transport Intracellular Transport Nuclear Import Signal Receptor Activity Protein Localization To Nucleus Protein Transport Establishment Of Protein Localization Structural Constituent Of Nuclear Pore Intermediate Filament Organization Nuclear Membrane Nucleobase-containing Compound Transport Nuclear Inclusion Body Protein Binding Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Intermediate Filament-based Process Intracellular Protein Transport Cellular Localization Protein Localization To Organelle Establishment Of Localization In Cell Establishment Of Protein Localization To Organelle Supramolecular Fiber Organization Nuclear Envelope Intracellular Protein Localization Intracellular Transport Of Virus Keratin Filament Host Cell NLS-dependent Protein Nuclear Import Complex Cytoskeleton Organization Small GTPase Binding Intermediate Filament Protein Export From Nucleus Keratinization Nuclear Pore Nuclear Basket Regulation Of Nucleocytoplasmic Transport Nuclear Pore Organization Identical Protein Binding RNA Export From Nucleus Nucleus Organization Organelle Organization Ribosomal Protein Import Into Nucleus Viral Penetration Into Host Nucleus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?